Biomedical subjects

Carol A Van Hulle

Publications and source records attributed to Carol A Van Hulle.

5 recordsLinked to original sources

PubMed2007

Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents.

Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8-year longitudinal study of children (n = 183). Half of the children met criteria for attention-deficit/hyperactivity disorder (ADHD) at 4-6 years and half were non-referred comparison children. Consistent with several studies, the non-additive association for the 10-repeat allele was significant for hyperactivity-impulsivity (HI) symptoms. However, consistent with other studies, exploratory analyses of the non-additive association of the 9-repeat allele of DAT1 with HI and oppositional defiant disorder (ODD) symptoms also were significant. The inconsistent association between DAT1 and child behavior problems in this and other samples may reflect joint influence of the 10-repeat and 9-repeat alleles.

Adolescent↗

PubMed2006

Testing descriptive hypotheses regarding sex differences in the development of conduct problems and delinquency.

Accurate descriptions of sex differences in the development of childhood conduct problems and adolescent delinquency will inform theories of their causes in fundamentally important ways. Using data on 4,572 offspring of a national sample of women, we tested descriptive hypotheses regarding sex differences. As predicted, the magnitude of sex differences varied with age, suggesting that multiple processes differentially influence levels of these behaviors in females and males across development. During childhood, boys scored lower on measures of cognitive ability and exhibited lower sociability and compliance and greater hyperactivity, oppositional behavior, and conduct problems. Most of these variables were associated with childhood conduct problems and adolescent delinquency equally in females and males, but maternal delinquency and early childhood sociability were correlated more strongly with childhood conduct problems in males and childhood compliance predicted adolescent delinquency more strongly in females. Both sexes exhibited both childhood-onset and adolescent-onset trajectories of delinquency. Although more males followed a childhood-onset trajectory, there were few sex differences in the early childhood risk correlates of either delinquency trajectory.

Adolescent↗

PubMed2006

Gender differences in temperament: a meta-analysis.

The authors used meta-analytical techniques to estimate the magnitude of gender differences in mean level and variability of 35 dimensions and 3 factors of temperament in children ages 3 months to 13 years. Effortful control showed a large difference favoring girls and the dimensions within that factor (e.g., inhibitory control: d = -.41, perceptual sensitivity: d = -0.38) showed moderate gender differences favoring girls, consistent with boys' greater incidence of externalizing disorders. Surgency showed a difference favoring boys, as did some of the dimensions within that factor (e.g., activity: d = 0.33, high-intensity pleasure: d = 0.30), consistent with boys' greater involvement in active rough-and-tumble play. Negative affectivity showed negligible gender differences.

Female↗

PubMed2004

Genetic, environmental, and gender effects on individual differences in toddler expressive language.

In this article, the authors examined the genetic and environmental factors influencing expressive language development in a sample of 386 toddler twin pairs participating in the Wisconsin Twin Project. Expressive language was assessed using 2 measures from the MacArthur Communicative Development Inventories-Short Form: Total Vocabulary and Two-Word Combination Use (L. Fenson et al., 2000). A sex-limitation structural equation model estimated the contribution of genetics, shared environment, and nonshared environment to individual variation. For vocabulary, heritability was higher for boys than for girls (20% vs. 8%). For word combination use, heritability was higher for girls (28% vs. 10%). However, the majority of individual variation in both boys and girls could be attributed to shared environment (54%-78%).

Environment↗

PubMed2002

Wisconsin Twin Panel.

The Wisconsin Twin Panel was initiated in 1994 to serve a study of the development of childhood mood and behavioral disorders. Families who give birth to twins within the state of Wisconsin are recruited within 6 months of the birth. The panel currently supports three ongoing, longitudinal research projects. Research foci include studying epigenetic contributions to emotional, physical, cognitive, and motoric development of infant and toddler twins; physiological concomitants of childhood temperament; and early risk and resiliency factors related to child psychopathology. All three studies include videotaped observational assessments and biological measures.

Child↗