Biomedical subjects

Claudio Migliori

Publications and source records attributed to Claudio Migliori.

4 recordsLinked to original sources

PubMed2006

Anticardiolipin and anti-beta2 glycoprotein I antibodies in infants born to mothers with antiphospholipid antibody-positive autoimmune disease: a follow-up study.

Infants born from mothers with antiphospholipid antibody (aPL) -positive autoimmune disease were prospectively evaluated for anticardiolipin and anti-beta2 glycoprotein I antibodies (group 1) and for growth and neurological development. The results were compared with those obtained from two age-matched control groups (group 2 and 3). All infants were negative for anticardiolipin at 12 months of life, whereas 14 (63.6%), eight (33.3%), and 10 (55.5%) of infants from group 1, 2, and 3, respectively, were positive for anti-beta2 glycoprotein I. At follow-up, all infants had normal growth and neurological development. No thrombotic complication was observed. The negativity of anticardiolipin in all infants at 12 months suggests that anticardiolipin detection is the best assay to evaluate the disappearance of maternal aPL and to estimate the potential risk of thrombosis associated with these antibodies. The high rate of anti-beta2 glycoprotein I positivity in all three groups of infants may indicate that the synthesis of this antibody is stimulated by aspecific factors.

Antibodies, Anticardiolipin↗

PubMed2005

Nasal bilevel vs. continuous positive airway pressure in preterm infants.

Our aim was to compare the effects of nasal bilevel positive airway pressure (N-BiPAP) and nasal continuous positive airway pressure (N-CPAP) on gas exchange in preterm babies. Twenty preterm infants (mean gestational age, 26.3 weeks; mean weight at study, 1,033 g) were evaluated. Patients received two repeated cycles of N-CPAP alternated with N-BiPAP, for a total of four alternated phases, each phase lasting 1 hr. Transcutaneous PO2 (TcPO2), transcutaneous PCO2 (tcPCO2), pulsoximetry, and respiratory rate were recorded every 15 min. Arterial blood gases and acid-base balance were measured at the beginning of the first study period on baseline CPAP and at the end of the last study period on bilevel positive airway pressure. During the two N-BiPAP phases, a statistically significant (P < 0.001) increase of peripheral oxygen saturation and tcPO2, and a significant (P < 0.001) reduction of tcPCO2 and respiratory rate, were noted as compared to the two N-CPAP periods. In addition, a significant improvement of PO2 (P < 0.003) and a reduction of PCO2 were noted at the end of the test (P < 0.02). In conclusion, N-BiPAP, as compared to N-CPAP, improved gas exchange in preterm infants.

Blood Gas Analysis↗

PubMed2004

High-frequency partial liquid ventilation in two infants.

Two infants on high-frequency oscillatory ventilation for chronic lung disease and severe respiratory failure, received a bolus of warmed and oxygenated perfluorodecalin up to residual functional capacity, followed by a continuous infusion of 6 ml/kg/hour. Our aim was to improve gas exchange without increasing ventilatory-induced lung injury. Heart rate, oxygen saturation, blood pressure, and TcPO(2)/TcPCO(2) were continuously monitored during treatment. Arterial blood gas was evaluated every 3 hours. Both patients showed improvement of gas exchange with a 13.6 and 12.5% reduction of oxygenation index, respectively. High-frequency partial liquid ventilation is an experimental ventilation technique that could be considered as rescue treatment, to improve oxygenation in subjects with critical respiratory failure. This method could probably produce less damage, than other ventilation modes, to severely injured lungs.

Female↗

PubMed2003

Effect on respiratory function of pressure support ventilation versus synchronised intermittent mandatory ventilation in preterm infants.

Our objective was to compare the effects of pressure support ventilation and synchronized intermittent mandatory ventilation on respiratory function in preterm babies. Twenty preterm infants (mean gestational age, 29 weeks; mean weight at study, 1,354 g) were evaluated. Patients received two repeated cycles of synchronized intermittent mandatory ventilation, alternated with pressure support ventilation, for a total of four alternated phases, each phase lasting 4 hr. Spontaneous respiratory rate, tidal volume, minute volume, and mean airway pressure were recorded hourly. The tidal volume released by the ventilator was limited to 6 ml/kg. During the two pressure support ventilation phases, a statistically significant reduction of respiratory rate and a significant increase of tidal and minute volume were noted, as compared to the two synchronized intermittent mandatory ventilation periods. Mean airway pressure significantly increased only after the first shift from synchronized intermittent mandatory ventilation to pressure support ventilation. The changes of minute volume and respiratory rate observed during pressure support ventilation did not persist after the return to synchronized intermittent mandatory ventilation. In conclusion, pressure support ventilation, as compared to synchronized intermittent mandatory ventilation, seemed to improve respiratory function in preterm infants.

Birth Weight↗