High-frequency partial liquid ventilation in two infants.

Claudio Migliori; Roberto Bottino; Agnese Angeli; Donatella Cattarelli; Gaetano Chirico

doi:10.1038/sj.jp.7211044

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High-frequency partial liquid ventilation in two infants.

Claudio Migliori·Roberto Bottino·Agnese Angeli·Donatella Cattarelli·Gaetano Chirico

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Abstract

Two infants on high-frequency oscillatory ventilation for chronic lung disease and severe respiratory failure, received a bolus of warmed and oxygenated perfluorodecalin up to residual functional capacity, followed by a continuous infusion of 6 ml/kg/hour. Our aim was to improve gas exchange without increasing ventilatory-induced lung injury. Heart rate, oxygen saturation, blood pressure, and TcPO(2)/TcPCO(2) were continuously monitored during treatment. Arterial blood gas was evaluated every 3 hours. Both patients showed improvement of gas exchange with a 13.6 and 12.5% reduction of oxygenation index, respectively. High-frequency partial liquid ventilation is an experimental ventilation technique that could be considered as rescue treatment, to improve oxygenation in subjects with critical respiratory failure. This method could probably produce less damage, than other ventilation modes, to severely injured lungs.

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Female Fluorocarbons Functional Residual Capacity High-Frequency Ventilation Humans Infant Infant, Newborn Infant, Premature Infant, Premature, Diseases Male Pulmonary Gas Exchange Respiratory Insufficiency Case Reports Journal Article

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Claudio Migliori, Roberto Bottino, Agnese Angeli, Donatella Cattarelli, Gaetano Chirico. 2004. High-frequency partial liquid ventilation in two infants.. https://doi.org/10.1038/sj.jp.7211044

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