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Biomedical subjects

D A Freedman

Publications and source records attributed to D A Freedman.

At least 19 recordsLinked to original sources
PubMed1993

How tautological are interspecies correlations of carcinogenic potencies?

Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al., however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al.

Animals↗
PubMed1990

Ex-smokers and the multistage model for lung cancer.

Most versions of the multistage model predict that when persons stop smoking, their excess risk for lung cancer will continue to increase. Discussion of the model usually indicate that the excess risk stabilizes. The data show that the risk declines. Implications for models of carcinogenesis are discussed.

Adult↗
PubMed1989

Multistage models for carcinogenesis.

The multistage model is tested on several human and animal data sets. It fits in some cases but not in others. With human lung cancer data, there is a drop in risk for ex-smokers quite different from the predictions of the model. The results are not conclusive but are compatible with the view that the multistage model provides a family of curves that often fit cancer incidence data, but may not capture the underlying biological reality.

Age Factors↗