Multistage models for carcinogenesis.

D A Freedman; W C Navidi

doi:10.1289/ehp.8981169

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Multistage models for carcinogenesis.

D A Freedman·W C Navidi

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Abstract

The multistage model is tested on several human and animal data sets. It fits in some cases but not in others. With human lung cancer data, there is a drop in risk for ex-smokers quite different from the predictions of the model. The results are not conclusive but are compatible with the view that the multistage model provides a family of curves that often fit cancer incidence data, but may not capture the underlying biological reality.

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Age Factors Animals Humans Lung Neoplasms Models, Biological Neoplasms Risk Smoking Time Factors Journal Article Research Support, U.S. Gov't, Non-P.H.S.Review

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D A Freedman, W C Navidi. 1989. Multistage models for carcinogenesis.. https://doi.org/10.1289/ehp.8981169

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