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Biomedical subjects

D Adair

Publications and source records attributed to D Adair.

7 recordsLinked to original sources
PubMed1999

Splenic rupture associated with severe preeclampsia. A case report.

BACKGROUND: Splenic rupture is a very rare event complicating pregnancy. Approximately 5% of cases reported have involved the postpartum period. Unrecognized, this complication is universally fatal. CASE: Preeclampsia and pulmonary edema complicated a 42-year-old woman's intrapartum care. After cesarean delivery she was supported with mechanical ventilation, blood products and invasive monitoring. Shortly thereafter, she became hypotensive and developed disseminated intravascular coagulation. During exploratory laparotomy a splenic capsular rupture was identified. Splenectomy and continued intensive care support ultimately reversed the severe end-organ consequences. CONCLUSION: It is extremely important that this condition be maintained in the diagnostic differential of post-operative hemodynamic instability. Failure to identify it is invariably fatal. Awareness and intervention are essential to ensure a good outcome.

Adult↗
PubMed1995

Sideswipe elbow fractures.

A retrospective review of all cases of sideswipe elbow fractures (SSEFs) treated at two community hospitals from 1982 to 1992 was conducted to determine the functional outcome of the operative treatment of SSEFs. All five injuries involved the left elbow, and they included open fractures of the olecranon, the radius and ulna, the ulna and humerus, the humerus, and traumatic amputation of the arm. Concomitant injuries included three radial nerve palsies and two injuries each to the median nerve, ulnar nerve, and brachial artery. Treatment included irrigation, debridement (repeated if necessary), open reduction and internal fixation, external fixation (one case), and delayed amputation (one case). An average of 130/-10 degrees elbow flexion/extension, and 60/60 degrees supination/pronation was obtained for the three of four patients with reconstructions who returned for follow-up.

Accidents, Traffic↗
PubMed1995

Clozapine use in female geriatric patients with psychoses.

This study was undertaken to evaluate the clinical response of geriatric patients with psychoses to the atypical neuroleptic drug, clozapine. Records of patients over 60 years of age (n = 12, all female) who had received clozapine over a 30-month period from selected hospitals in Western Pennsylvania were reviewed. Among the six patients who were rapidly titrated (300 mg/day in 3 weeks), none are currently receiving clozapine, while four patients who received a slower titration and lower dosage (range, 25 mg/day to 300 mg/day; mean, 150 mg/day) remain clinically improved on stable doses of clozapine. Postural hypotension affected seven patients, and was the reason for discontinuation of clozapine in five patients. One patient experienced nonfatal agranulocytosis, and one subject experienced leukopenia. One patient died from causes unrelated to clozapine. This retrospective study suggests both a low-dose and slow-titration strategy for initiating clozapine among elderly patients, similar to the use of other psychotropic drugs in the elderly, as well as close attention to postural hypotension, agranulocytosis, and drug interactions.

Aged↗
PubMed1985

The in vitro development of extended-release solid oral dosage forms.

A system is described for developing extended-release products, based upon predicting or simulating the entire plasma level-time curve to be expected from the administration of a controlled-release oral dosage form. Termed "biorelevant dissolution," it employs the product's in vitro dissolution behavior and the drug's pharmacokinetic parameters in conjunction with a classical pharmacokinetic model. The basic system is described along with some pertinent examples.

Administration, Oral↗
PubMed1984

Dissolution profile determination of a multicomponent product using a rapid liquid chromatographic analysis.

A system was developed which is capable of monitoring the dissolution profiles of each of the active components in a two-component combination product. The UV spectra of the two drugs (metoprolol and hydrochlorothiazide) overlap considerably, making conventional UV analysis of either component unrealistic. By resolving the two drugs on a high-performance liquid chromatographic (HPLC) system both can be quantitated after separation. The analysis is sufficiently short to allow for the use of a six-station dissolution tester in tandem with an HPLC for determination of dissolution profiles. The HPLC system and equipment, can monitor six samples of this product at 5-min intervals in real analysis time.

Chemistry, Pharmaceutical↗