The in vitro development of extended-release solid oral dosage forms.

L J Leeson; D Adair; J Clevenger; N Chiang

doi:10.1007/bf01059332

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The in vitro development of extended-release solid oral dosage forms.

L J Leeson·D Adair·J Clevenger·N Chiang

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Abstract

A system is described for developing extended-release products, based upon predicting or simulating the entire plasma level-time curve to be expected from the administration of a controlled-release oral dosage form. Termed "biorelevant dissolution," it employs the product's in vitro dissolution behavior and the drug's pharmacokinetic parameters in conjunction with a classical pharmacokinetic model. The basic system is described along with some pertinent examples.

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Administration, Oral Delayed-Action Preparations Dosage Forms Solubility Tablets Technology, Pharmaceutical Journal Article

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L J Leeson, D Adair, J Clevenger, N Chiang. 1985. The in vitro development of extended-release solid oral dosage forms.. https://doi.org/10.1007/bf01059332

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