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Biomedical subjects

D Annunziato

Publications and source records attributed to D Annunziato.

9 recordsLinked to original sources
PubMed1982

Atypical measles syndrome: pathologic and serologic findings.

The clinical course of measles occurring in 17 adolescents who had previously received killed measles vaccine is described. All adolescents had a peripheral dermatitis. Fifteen had characteristic pulmonary infiltrates. Serologic study in six adolescents using immunoprecipitation of 35S-methionine-labeled measles virus antigens revealed that 5/6 acute sera lacked antibody to the hemolysin antigen whereas 5/6 sera contained antibody to hemagglutinin antigen. Skin biopsies, obtained from three patients, demonstrate a combination of an Arthus reaction and delayed hypersensitivity. The typical measles histologic complex was absent. Measles virions were seen in the deep dermal blood vessels. The serologic and histopathologic presentation of this disease indicates that killed vaccine does not adequately induce antibody to the hemolysin (F) which is necessary to prevent cell-to-cell spread of paramyxoviruses. Killed vaccine does, however, produce hemagglutinin antibody and simultaneously incites later hypersensitivity to wild virus infection, producing the unusual dermatopathologic reaction seen.

Adolescent↗
PubMed1978

Staphylococcal scalded skin syndrome. A complication of circumcision.

Numerous complications have been reported as a result of neonatal circumcision. We describe here three cases of staphylococcal scalded skin syndrome that were thought to be due to infected circumcisions. A review of the literature failed to disclose descriptions of staphylococcal scalded skin syndrome as such a complication. In spite of recent American Academy of Pediatrics recommendations against routine circumcision, it will continue to be a common procedure. Careful preoperative and postoperative screening and guidance are urged to prevent staphylococcal scalded skin syndrome and other complications.

Circumcision, Male↗