Case reports and small case series: primary basal cell carcinoma of the conjunctiva with intraocular invasion.
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Aged↗
Biomedical subjects
D B Lyon
Publications and source records attributed to D B Lyon.
Nasopalpebral lipoma-coloboma syndrome.
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Abnormalities, Multiple↗
Management of complications of blepharoplasty.
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Eyelids↗
Noninfectious inflammatory response to gold weight eyelid implants.
We describe three patients with noninfectious inflammatory reactions to gold weight eyelid implants, a complication not previously reported. Eyelid edema and erythema developed gradually in each patient, and maximal inflammation that prompted treatment was present at 12, 3, and 5 weeks, respectively, after surgery in the three patients. Management involved removal of the implant in the first patient, oral corticosteroids followed by replacement of the implant by a platinum weight in the second patient, and a local corticosteroid injection with retention of the implant in the third. Histopathological features included a thick eosinophilic coagulum at the tissue-gold interface and an intense, predominantly lymphocytic infiltrate in the collagenous capsule that surrounded the implants. Gold weight eyelid implants can elicit a gradually progressive inflammatory response. In at least some cases, local corticosteroid injection may suppress the inflammation and permit retention of the implant.
Aged↗
Polyphenotypic small-cell orbitocranial tumor.
A male infant was born with a massive orbitocranial tumor without evidence of metastasis. On light microscopy, the histologic pattern of the tumor was that of a largely necrotic and highly undifferentiated small round cell neoplasm of uncertain origin. Ultrastructural features of the primitive cells included a rare tight junction and myofibril. Immunohistochemical studies showed positive staining for cytokeratin, vimentin, muscle-specific actin, neuron-specific enolase, and S100 protein and negativity for desmin and leukocyte common antigen. We believe this case represents an example of a polyphenotypic small-cell tumor of childhood with epithelial, rhabdomyoblastic, and neuroectodermal differentiation.
Humans↗
Unilateral ptosis and eye dominance.
We studied the relationship between eye dominance (Scobee test) and upper lid level (MRD) in 54 patients with unilateral ptosis or asymmetric bilateral ptosis (> or = 2 mm difference in MRD) using the phenylephrine test. A contralateral lid drop was measured in 12/54 patients after instillation of 2.5% phenylephrine in the more ptotic eye and occurred in both congenital (3) and acquired (9) ptosis cases. A contralateral lid drop was seen in 7/14 (50%) patients whose ptosis was greater in the dominant eye and in 5/40 (12.5%) patients whose ptosis was greater in the nondominant eye (p = .01). Contralateral lid drops > or = 1 mm were present in 7/54 patients, and 6/14 (43%) of them had greater ptosis on the dominant side and 1/40 (2.5%) on the non-dominant side (p = .001). There was no association between contralateral pseudoretraction and either visual acuity or severity of ptosis. These results suggest that levator muscle tone is influenced by eye dominance when ptosis is present. The preoperative evaluation of unilateral or asymmetrical bilateral ptosis cases should include the Scobee and phenylephrine tests to unmask contralateral upper lid pseudoretraction.
Adolescent↗
Identification of orbital lymphatics: enzyme histochemical light microscopic and electron microscopic studies.
The presence of orbital lymphatics in the primate model is demonstrated using light and electron microscopic enzyme histochemistry. In addition, strictly morphological definitions of lymphatics, such as discontinuous basal lamina, thin and irregular walls, anchoring filaments, and attenuated endothelial cell cytoplasm, were applied. This study confirmed the presence of conjunctival lymphatics reported by others. It also clearly demonstrated the presence of orbital arachnoid and lacrimal gland lymphatics that have not been previously described. A few areas of the extraocular muscles and connective tissue at the orbital apex also showed evidence of the presence of lymphatic vessels. Additional work is needed to define the nature and extent of orbital lymphatics as well as their connection to the extraorbital lymphatic system.
Adipose Tissue↗
Epithelioid hemangioendothelioma of the orbital bones.
PURPOSE: The authors report a case of an epithelioid hemangioendothelioma arising in the orbital bones. A review of the literature related to this rare orbital neoplasm identified eight well-documented cases, one of which occurred in a patient younger than that reported here, but none of which originated in bone. METHODS: A 3 1/2-month-old boy had a left inferior orbital mass that had grown rapidly over a 3-day period. An emergency computed tomography scan showed a large neoplasm with significant bone destruction of the zygoma and maxilla. Initial examination suggested a rhabdomyosarcoma, and a transconjunctival biopsy was performed, which was complicated by significant blood loss. The final pathologic diagnosis was an epithelioid hemangioendothelioma, or grade 2 hemangioendothelioma, of bone origin. No other sites of disease were found on metastatic survey. Subsequent treatment consisted of an en bloc tumor resection sparing the orbital soft tissues and globe. RESULTS: The patient is free of disease and has normal visual fixation and ocular motility 20 months after surgery. CONCLUSION: Epithelioid hemangioendothelioma, a vascular malignancy of endothelial cell origin, very rarely involves the orbit. This case is notable for its early development, rapid growth, bony origin, and epithelioid histology.
Biopsy↗
Sympathetic nerve anatomy in the cavernous sinus and retrobulbar orbit of the cynomolgus monkey.
We present new information regarding the sympathetic nerve anatomy in the cavernous sinus and retrobulbar orbit of the cynomolgus monkey. Postganglionic sympathetic nerves were identified using an immunoperoxidase technique in which the primary antiserum was directed against tyrosine hydroxylase, the rate-limiting enzyme in norepinephrine synthesis. Our work is unique in adapting this staining method to paraffin-embedded tissue. This technique allows sympathetic nerve fibers to be distinguished from other autonomic, sensory, and motor nerves. A large sympathetic nerve bundle lateral to the internal carotid artery in the cavernous sinus gave off one or more branches that leave the artery to encircle the abducens nerve. Further division occurs within the cavernous sinus, but all sympathetic nerve fibers destined for the orbit entered it through the superior orbital fissure. None pass through the optic canal. In the orbit, sympathetics were associated with the ophthalmic artery and some of its branches and with the sensory root to the ciliary ganglion. After entering the ganglion, the sympathetic fibers were lost to detection in most specimens, but they were again seen in a single short ciliary nerve in one instance. Sympathetic nerve fibers were not detected adjacent to several structures identified in the human anatomy literature, such as the intracranial and intracanalicular segments of the ophthalmic artery, the nasociliary nerve, the long ciliary nerves, the nerve to the inferior oblique muscle, or the lacrimal artery and nerve.
Animals↗
Endoscopic laser-assisted lacrimal surgery.
Since Sept. 1, 1989, we have successfully performed 20 video-endoscopic, transnasal, laser-assisted lacrimal procedures on 18 patients ranging in age from 3 to 88 years. This technique avoided a cutaneous scar and caused less surgical trauma and bleeding than that seen in conventional lacrimal surgery, which shortened postoperative recovery time and lessened postoperative pain. With minor modifications in surgical technique, both dacryocystorhinostomy and conjunctivodacryocystorhinostomy were performed with either the potassium titanyl phosphate or carbon dioxide lasers. The use of the video endoscope allowed laser surgery to be performed across a broad range of intranasal structural variations and provided an excellent medium for teaching this new technique.
Adolescent↗
Canalicular stenosis following probing for congenital nasolacrimal duct obstruction.
A canalicular stenosis was identified in 29 of 66 (44%) children and 35 of 80 (44%) lacrimal drainage systems undergoing silicone intubation for congenital nasolacrimal duct obstruction, having previously had unsuccessful probings. The stenoses were equally divided between boys and girls and between right and left sides. There was no significant difference in age at the time of probing, number of prior probings, or age at intubation between children with and without canalicular stenosis. Stenoses may be congenital or acquired as a result of faulty probing. Any child undergoing a second lacrimal procedure after a failed probing should be evaluated for evidence of a canalicular stenosis. If a stenosis is present, a silicone stent should be placed to try to salvage the canaliculus.
Child, Preschool↗
Evidence of direct damage to extraocular muscles as a cause of diplopia following orbital trauma.
Vertical diplopia following orbital trauma has frequently been attributed to entrapment of the inferior rectus muscle. The high incidence of spontaneous recovery and negative forced ductions suggests that a significant percentage of these patients have other causes for their diplopia, such as direct damage to the extraocular muscles or their innervating nerves. In five patients with blunt trauma to the orbit, high-resolution computed tomography (CT) scanning showed evidence of hemorrhage or edema within the inferior rectus or inferior oblique muscle that was paretic on clinical exam. No evidence of entrapment was noted in any of the five patients. The course was variable. Three patients had almost complete recovery, whereas two demonstrated improvement but with residual restriction or paresis. Our findings support direct extraocular muscle (EOM) damage as the primary cause of diplopia in these patients. High-resolution CT scanning helps in selecting such patients in whom orbital intervention is unnecessary. The clinical goals of binocular single vision in primary and reading positions are emphasized.
Adult↗
Eyelid gas gangrene.
A case of eyelid gas gangrene caused by Clostridium hastiforme is reported. The infection followed an alkali injury that probably aided proliferation of the organism by inducing local tissue ischemia. Debridement combined with antibiotic therapy controlled the infection, and the large lid defect healed satisfactorily by secondary intention.
Adult↗
Secondary bacterial keratitis in herpes zoster ophthalmicus.
We report a case of an unusual complication of herpes zoster ophthalmicus, secondary bacterial keratitis. Compared with previously reported cases, ours is unique in its early occurrence in the course of zoster and the lack of predisposing factors such as steroid use, contact lens use, or prior corneal disease or surgery. The opportunistic pathogen Branhamella cattarhalis responded well to medical therapy. We feel that bacterial superinfection must always be a concern in patients with herpes zoster keratitis, even early in their often prolonged chronic disease.
Bacteriological Techniques↗
Studies on the solubility of Ca, Mg, Zn, and Cu in cereal products.
In vitro studies were carried out on a range of cereal products of differing phytate content in order to examine the likely release and fate of the Ca, Mg, Cu, and Zn present in cereals on passing through the stomach and small intestine. The Ca, Mg, Cu, and Zn was released by extraction with HCl (pH = 1) for 0.5 h. The addition of HCO-3 to pH 7 caused varying levels of precipitation ranging from 100% for Zn in high phytate cereals to 0% for Ca and Mg in low phytate cereals. Extracted Cu was not precipitated. The addition of the organic ligands EDTA and citric acid prevented precipitation and it is postulated that naturally occurring soluble ligands are an important controlling factor in determining the bioavailability of essential minerals.
Biological Availability↗