Polyphenotypic small-cell orbitocranial tumor.

D B Lyon; R K Dortzbach; E Gilbert-Barness

doi:10.1001/archopht.1993.01090100110037

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Polyphenotypic small-cell orbitocranial tumor.

D B Lyon·R K Dortzbach·E Gilbert-Barness

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Abstract

A male infant was born with a massive orbitocranial tumor without evidence of metastasis. On light microscopy, the histologic pattern of the tumor was that of a largely necrotic and highly undifferentiated small round cell neoplasm of uncertain origin. Ultrastructural features of the primitive cells included a rare tight junction and myofibril. Immunohistochemical studies showed positive staining for cytokeratin, vimentin, muscle-specific actin, neuron-specific enolase, and S100 protein and negativity for desmin and leukocyte common antigen. We believe this case represents an example of a polyphenotypic small-cell tumor of childhood with epithelial, rhabdomyoblastic, and neuroectodermal differentiation.

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Humans Immunoenzyme Techniques Infant, Newborn Male Mesenchymoma Orbital Neoplasms Phenotype Rhabdomyosarcoma Skull Neoplasms Case Reports Journal Article

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D B Lyon, R K Dortzbach, E Gilbert-Barness. 1993. Polyphenotypic small-cell orbitocranial tumor.. https://doi.org/10.1001/archopht.1993.01090100110037

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