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Biomedical subjects

D B Teculescu

Publications and source records attributed to D B Teculescu.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

Transfer factor for the lung, airway obstruction and hyperinflation in chronic bronchitis and emphysema.

The interrelationships of breath holding lung transfer factor (TCO) and transfer coefficient (KCO) with ventilatory obstruction (FEV1.0) and FEV1.0/VC) and hyperinflation (RV and RV/TLC) were studied in 37 patients with chronic nonspecific lung disease with a FEV1.0 of 1.5 litre or less classified as "bronchitic", "emphysematous" or "intermediate" according to Nash, Briscoe and Cournand (1965). No relationships could be found between TCO and airway obstruction or hyperinflation. KCO tended to decrease as RV increased (r=-0.26) and was weakly related to the FEV1.0/VC ratio in "intermediate" (r=0.34) and "emphysema" (r=0.29) patients but these relationships were nonsignificant.

Adult↗
PubMedDate not supplied

Breathlessness and blood oxygen tension in patients with chronic bronchitis and emphysema.

The dyspnea grade (MRC scale) was confronted with the arterial oxygen tension (PaO2) measured at rest in a group of 51 patients with chronic obstructive lung disease with moderate or severe impairment of ventilatory function (FEV 1.0 less than 1.5 1). For the group as a whole no correlation was found, but in the "bronchitic" subgroup (clinical-roentgenologic and biologic criteria) a tendency of PaO2 to decrease with the increase in dyspnea severity was apparent. The linear correlation coefficient did not attain the significance threshold owing to the limited number of observations (r = 0.46; p greater than 0.05).

Adult↗
PubMedDate not supplied

Ventilatory function in pre-school children snorers and nonsnorers.

BACKGROUND: The value of flow-volume curves alterations for screening for sleep apnoea is controversial in adults. OBJECTIVE: The purpose of the present study was to assess the possible value of flow-volume curves, in snoring pre-school children to detect upper airway abnormal dynamics. METHODS: We analysed ventilatory function of 190 children aged 5 to 6 years from nine kindergartens in Nancy, France, according to the presence or absence of snoring as declared by their parents. RESULTS: More than half (103 = 54%) of the children never snored; 26 (= 13.7%) snored only with colds, 42 (22.1%) snored occasionally, and 19 (= 10%) snored habitually. The "saw tooth" sign described in adults by Sanders et al in 1981 was absent in all the children in this study, and the height-adjusted forced expiratory volume in one second (FEV1/m2) was similar across the four groups. The height-adjusted peak expiratory flow (PEF/m2) decreased uniformly (but insignificantly) from the group of non-snorer (2.11 +/- 0.381/s/m2) through the group of children snoring with colds. (2.05 +/- 0.37) to the group of children snoring occasionally (1.99 +/- 0.33); no significant decrease was found in the group of habitual snorers (2.06 +/- 0.36). CONCLUSION: In this group of young children, we were unable to find the alteration of the expiratory flow-volume loop described in part of the studies in adults. We cannot, however, exclude an alteration of the inspiratory arm of the loop, as this was not recorded by us. Our results, suggesting a reduction in peak expiratory flow with increase in frequency of snoring need to be validated in a larger population of children.

Child↗
PubMedDate not supplied

The single-breath nitrogen test does not detect functional impairment in children with passive exposure to tobacco smoke.

Respiratory symptoms and pulmonary function were compared in 46 nonsmoking children aged 10 to 16 years, whose parents were smokers, and an identical number of children (matched for sex, age and height) whose parents were nonsmokers. Passive exposure to parental tobacco smoke resulted in a higher prevalence of respiratory symptoms, more frequent upper airway infections and a significant decrease in forced expiratory flows; these effects were more marked in boys. The single-breath nitrogen washout test, a sensitive test of small airways obstruction in adults, did not detect any effect of involuntary smoking in this limited sample of children.

Adolescent↗