Single-breath total lung capacity determinations in patients with non-obstructive lung disease.
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Biomedical subjects
Publications and source records attributed to D B Teculescu.
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The measurement of arterial blood oxygen tension (PaO2) in 54 patients with chronic nonspecific lung disease with a FEV1.0 of 1.51 or less, in a stable clinical state, at rest, indicated subnormal results to be more frequent among "bronchitics" (79 per cent with hypoxemia) than than among "emphysematous" patients (63 per cent with hypoxemia). The patients were classified according to a mixed clinical-roentgenologic-biological "score" (Nash et al., 1965). A significant correlation was found between PaO2 and the "emphysema score" (r=0.36; p less than 0.01). The average PaO2 was significantly (p less than 0.02) lower in "bronchitics" (65.5 +/- 8.8 mmHg; n = 14) as compared to the "emphysema" group (71.8 +/- 5.7; n = 19), in agreement with the data of the literature.
The assessment of a new bellows spirometer against a water spirograph showed: slight alinearity, minimal overestimation of FVC (1.7%) and underestimation of FEV 1-0 (2.9%) as well as of the ratio FEV 1-0/FVC (4.8%). The main advantages of the instrument are: lightness, easy operation, ruggedness and low cost; it seems mainly indicated for use in large scale field surveys.
The severity of dyspnea (MRC scale) was confronted to the blood carbon dioxide tension (PaCO2) in 45 patients with chronic nonspecific lung disease having moderate or severe airway obstruction (FEV1.0 of less than 1.5 liters). The patients were classified as "bronchitic", "emphysematous" and "intermediate" using a 10- criterion (clinical, roentgenologic and biological) "emphysema score". No correlation between dyspnea grade and PaCO2 was found in "bronchitic" and "intermediate" patients; in the "emphysematous" subgroup PaCO2 tended to rise as dyspnea was more severe, but the linear correlation coefficient (r= +0.37) did not reach the significance threshold, which is high (0.468) for such a limited number of observations.