Biomedical subjects

D B Vigneron

Publications and source records attributed to D B Vigneron.

75 records · Page 5Linked to original sources

PubMedDate not supplied

High-sensitivity coil array for head and neck imaging: technical note.

The purpose of this study was to develop coils for MR imaging of the head and neck region, with the aim of improving sensitivity and coverage. A head and neck phased array coil was constructed and compared with volume and temporomandibular joint surface coils for sensitivity and coverage in phantom studies. An algorithm was implemented to correct for the nonuniformity in the surface coil reception profile. Its application to high-resolution T2-weighted imaging in healthy volunteers was investigated.

Head↗

PubMedDate not supplied

Short echo time MR spectroscopic imaging for neonatal pediatric imaging.

A short echo time (30 milliseconds) MR spectroscopic imaging pulse sequence was implemented for applications of neonatal brain imaging. Multiple spatial saturation bands were used to eliminate strong signals originating from the subcutaneous lipids to enable volumetric region coverage. Metabolite signal intensity-to-noise ratio < or =40 was acquired in 9 minutes of scan time over an 8 x 8 x 8 spatial matrix with 1 cm(3) isoresolution.

Brain Chemistry↗

PubMedDate not supplied

Clinical proton MR spectroscopy of neurodegenerative disease in childhood.

PURPOSE: To determine the contribution of MR spectroscopy in the assessment of childhood neurodegenerative disease. METHODS: Fifty-one subjects (7 weeks to 17 years of age), 22 with either hereditary (n = 16) or acquired (n = 6) neurodegenerative disorders and 29 age-matched control subjects, were studied with combined proton MR spectroscopy and MR imaging. Single-voxel (2.0-8.0 cc) MR spectra were acquired at 1.5 T, with either short-echo-stimulated echoes and/or long-echo spin echoes. RESULTS: MR spectra exhibited signals from n-acetyl-, creatine-, and choline-containing compounds, neurotransmitters (glutamate), intracellular mediators (inositols), and glycolytic products (lactate). Abnormal MR spectra in neurodegenerative disorders reflected: demyelination, neuronal loss, and gliosis (increased mobile lipid presence and reduction of n-acetylaspartate to choline); metabolic acidosis (lactate accumulation); and neurotransmitter neurotoxicity (increased glutamate, glutamine, and inositols). CONCLUSION: Proton MR spectroscopy may complement MR imaging in diagnostic assessment and therapeutic monitoring of neurodegenerative disorders.

Adolescent↗