Biomedical subjects
D Barrett
Publications and source records attributed to D Barrett.
Clinical significance of screening for antibody to ribonucleoprotein.
Of more than 1500 sera screened for antinuclear antibody 13 were positive for antiribonucleoprotein (RNP). Nine patients had either systemic lupus erythematosus or mixed connective tissue disease. Four other had no significant medical problems. The detection of anti-RNP antibody does not have diagnostic specificity and may not indicate active collagen disease.
Chronic urticaria dnd vasculitis.
Of 231 patients with chronic urticaria, eight presented with arthritis. All had elevated sedimentation rates, five had depressed complement (CH50) and two elevated serum immune complexes (IC). Skin biopsies were abnormal in only four patients, unrelated to abnormalities of CH50 or IC. No single diagnostic test was consistently abnormal.
Ambulatory care in the cities: a shift to the hospitals.
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The gay report on sexually transmitted diseases.
Most studies of sexually transmitted diseases in homosexual men have examined prevalence in clinic populations; for comparative purposes, we analyzed data from a survey of 4,329 gay men conducted in 1977. Among 4,212 respondents to the self-administered questionnaire, 66.8 per cent reported previous infection with pediculosis; 38.4 per cent, gonorrhea; 24.1 per cent, nonspecific urethritis; 18.1 per cent, venereal warts; 13.5 per cent, syphilis; 9.7 per cent, hepatitis; and 9.4 per cent, herpes. Number of different lifetime sexual partners best predicted histories of symphilis (r = .249), gonorrhea (r = .402), and the other diseases; frequency of checkups, years as a practicing homosexual, and furtive sexual activities were among the many other significant correlates of venereal infections. Respondents most often sought examinations from private physicians (39.4 per cent); those who visited gay clinics were examined most often and felt most positive about their medical care. Gay men who participated in the survey reported frequent infections with many of the same sexually transmitted diseases often seen in private medical practices, public VD clinics, and gay health centers. Since high rates of disease are related to large numbers of different partners, frequent exposures with anonymous contacts, and anal intercourse, we recommend frequent examinations for those whose life-styles include these characteristics.
Demonstration of a dog liver immunosuppressive factor active in vitro.
These studies define the presence of an immunosuppressive factor in dog liver that is active in vitro. A crude dog liver extract was prepared by saline extraction and ultracentrifugation. In vitro immunosuppressive activity of the extract was assayed by its influence on standard phytohemagglutinin mitogen stimulation assays (PHA), two-way mixed lymphocyte culture (MLC) reactions, and primed lymphocyte culture (PLC). In six experiments with four extracts, the mean percentage of inhibition (MPI) of dog lymphocytes in PHA mitogen stimulation assays was 102.0 +/- 3.6. In two human MLC experiments, the extract produced an MPI of 102.3 +/- 0.3. In one canine MLC the MPI was 102.5. In three PLC experiments the MPI was 92.7 +/- 8.0, indicating that the extract inhibited sensitization. Cytotoxicity of the extract was shown not to be the mechanism of proliferation inhibition by restimulation of cells washed free of extract, concurrent eosin viability studies, and documentation of normal base proliferation of cells after extract was washed from them. We concluded that there is a naturally occurring immunosuppressive agent in dog liver that is active in vitro as demonstrated by inhibition of PHA MLC, and PLC cellular proliferation assays. The activity is not attributable to cytotoxicity.
Multihospital systems: the process of development.
It seems clear that organizations grow by passing through periods of conflict and change with varying degrees of success...a company's strategy in time determines its structure and change occurs in relation to changes in marked demand.
Effect of growth hormone on vitamin D metabolism.
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Purification and partial characterization of hatching protease of the sea urchin, Strongylocentrotus purpuratus.
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The Janus principle.
The leaders who guide health organizations into formal and informal alliances must serve their own organizations while meeting the demands of a larger environment. Those who recognize the need for change in leadership style are most likely to help their organizations to maintain their strengths within new structures. The authors examine several theories of leadership style, describe the developmental stages involved in forming an inter-institutional organization, and discuss the new leadership tasks and skills that collaboration mandates.
Looking forward into nursing home specialization: the diabetic questionnaire.
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Hatching enzyme of the sea urchin Strongylocentrotus purpuratus.
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Phospholipase activity in squid and frog axons.
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Effect of aging on physical properties of phenylbutazone tablets.
A study was made of the influence of age on the physical properties of phenylbutazone tablets BP, with special reference to in vitro dissolution rates. Past batches of tablets showed a progressive decrease in dissolution rate with age. This effect could be simulated in short periods by using elevated temperatures. The effect appears to be connected with the subcoat layer of the sugar coating of the tablet which adheres more strongly to the tablet core and slows down its disintegration.
Xanthine dehydrogenase accumulation in developing Drosophila eyes.
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Cellular composition of the nipple aspirate specimen of breast fluid. I. The benign cells.
A nipple aspirator device was used to obtain breast secretions for cytologic examination, as well as for viral and biochemical analysis. Examination of the first 1,456 specimens from 796 women revealed ductal epithelium in 54%. Ductal epithelial cells were often absent in specimens from normal women; however, 78.5% of women with benign breast disease on tissue biopsy had specimens containing ductal epithelium. Apocrine metaplastic cells were a further indication of the presence of breast disease, and were rarely found in specimens from asymptomatic women. Foam cells were often abundant in specimens from normal breasts, but were found in decreased numbers in specimens from women benign breast disease. Differences in the occurrence of ductal epithelial cells, apocrine metaplastic cells, and foam cells suggest an alteration in the rate of maturation of ductal epithelium in women with both benign and malignant breast disease. The finding of a relative abundance of cells in nipple aspirate specimens from women with breast disease and few or no cells in specimens from women with normal breasts is believed to be of great importance in the cytologic evaluation of nipple aspirate specimens.
Cellular composition of the nipple aspirate specimen of breast fluid. II. Abnormal findings.
Studies of cellular findings in nipple aspirate specimens from 796 women revealed 50 women with abnormal cells and/or microcalcifications. The clinical correlation of these abnormalities with breast cancer appears to be highly significant: abnormal cells were found in 50% of the satisfactory specimens from women who had breast cancer or who had had a previous mastectomy for breast cancer. Continued observation of the women for evidence of regression, persistence, or progression of the cytologic abnormalities is required to determine the significance of the abnormalities. Microcalcifications were present in nipple aspirates from 27% of the women whose mammograms were interpreted as showing calcification. The absence of mammographic confirmation of the cytologic findings of microcalcifications may be an indication for re-evaluation of the existing mammograms and repeat clinical and mammographic examination at more frequent intervals for early localization of small lesions.