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D Bockus

Publications and source records attributed to D Bockus.

At least 19 recordsLinked to original sources
PubMed1989

Tubuloreticular structures and cylindrical confronting cisternae: a review.

Tubuloreticular structures (TRS) and cylindrical confronting cisternae (CCC) are unique subcellular structures that arise from the membranes of the rough endoplasmic reticulum of a variety of cell types. In vivo, they occur most frequently in endothelial cells and lymphocytes from patients with autoimmune diseases and viral infections; they are seen in these cells in almost all acquired immunodeficiency syndrome (AIDS) patients. The inducer(s) of TRS and CCC in vivo is (are) not firmly established. However, clinical and experimental studies indicate that the occurrence of these structures in these diseases is directly related to the endogenous elevation of alpha- and beta-interferon but not to gamma-interferon. Although CCC have been seen and reported to occur in human and primate cells since the late 1970s, their presence did not arouse much clinical and scientific interest until 1983 when they were observed in lymph node tissues of AIDS patients. The nature and pathogenesis of TRS and CCC are obscure. Through the years, many hypotheses have been proposed. They range from suggestions of these structures being incomplete viral particles to being nothing more than accumulated proteins; and from reference to these structures as specific markers for diseases to a generalized cell reaction to certain biological stimuli. In vitro investigations with lymphoblastoid cell lines have contributed a great deal in illuminating the potential clinical significance and the in vivo inducer(s) of TRS and CCC. Both the TRS and CCC are now known to be induced in vitro by alpha- and beta-interferon in some lymphoblastoid cell lines. However, only TRS and not CCC are induced in healthy donor lymphocytes and endothelial cells. Isolation of TRS and CCC using the lymphoblastoid cell system will help clarify the nature, the pathogenesis, and the importance of TRS and CCC in human diseases.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Familial mesothelioma: a report of two families.

Five reports of familial mesothelioma in which mesotheliomas occurred in two or more family members have been recorded in the medical literature. In this report, we describe two examples of familial mesothelioma. In one family, three brothers who worked in the asbestos insulation industry developed mesothelioma. In the second family, the father, who was occupationally exposed to asbestos, died from a tubulopapillary peritoneal mesothelioma 11 years before his son died from an identical histologic type of peritoneal mesothelioma. Our report, as with those previously recorded, suggests that genetic factors may be important in the genesis of some mesotheliomas.

Adult↗
PubMed1988

Induction of cylindrical confronting cisternae (AIDS inclusions) in Daudi lymphoblastoid cells by recombinant alpha-interferon.

Cylindrical confronting cisternae (CCC), also known as test-tube and ring-shaped forms, are frequently present in the cytoplasm of lymphocytes and occasionally in other cells from patients with acquired immunodeficiency syndrome (AIDS). Recent data indicate that the presence of these cisternae and tubuloreticular structures (TRS) in lymphocytes from patients at risk for AIDS is predictive of the development of this syndrome. CCC are formed by an alteration of the membranes of the rough endoplasmic reticulum, but the mechanism by which they are formed or demonstration of their induction by specific agents has not been previously reported. We cultured Daudi lymphoblastoid cells in medium containing recombinant alpha-interferon and induced the formation of both TRS and CCC. The number of CCC formed in Daudi cells was directly proportional to the concentration of interferon used and the length of culture. CCC were in direct continuity with TRS, which were induced in cells by interferon at an earlier time. The percentage of cell sections containing TRS stayed the same or decreased somewhat after 72 hours of culture, whereas the number of CCC increased. Our results indicate that CCC could be present in various cells from patients with AIDS and other diseases as a result of elevated interferon levels in these conditions.

Acquired Immunodeficiency Syndrome↗
PubMed1986

The widespread distribution of Langerhans cells in pathologic tissues: an ultrastructural and immunohistochemical study.

Ultrastructural and/or immunohistochemical analysis of approximately 500 specimens revealed widespread distribution of Langerhans cells in pathologic specimens. More than half of the tissue specimens were from patients with a variety of pulmonary diseases. In all specimens in which Langerhans cells were identified ultrastructurally, they were also identified by an immunoperoxidase technique for the visualization of S-100 protein; the latter technique also revealed the dendritic nature of these cells. Langerhans cells were present in 80 to 93 per cent of 66 pulmonary adenocarcinomas and 17 per cent of squamous cell lung cancers; they were not observed in neuroendocrine lung carcinomas or mesotheliomas. They were also observed in benign inflammatory conditions of the lung of several types and in a variety of other malignant neoplasms and disease processes. The Langerhans cells in these tissues varied from few to many. They were most numerous in bronchioloalveolar cell carcinoma, sometimes appearing almost as frequently as tumor cells, and rare in some benign pulmonary conditions and other tumors. The function of Langerhans cells in these conditions is unknown, but they may have an immunologic function, such as antigen processing and presentation to T lymphocytes.

Carcinoma↗
PubMed1985

Idiopathic fibrosing alveolitis: a review with emphasis on ultrastructural and immunohistochemical features.

Fibrosing alveolitis is a usually chronic pulmonary disease affecting middle-aged men and women and causing progressive dyspnea. This review discusses the nosologic, etiologic, immunopathogenic, histologic, immunohistochemical and ultrastructural features of this condition. A hypothesis is presented suggesting microvascular damage as the primary pathologic change in cases associated with collagen vascular diseases and viral pneumonia.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Endothelial cell damage and tubuloreticular structures in interstitial lung disease associated with collagen vascular disease and viral pneumonia.

Lung tissue showing the light microscopic changes of interstitial inflammation and fibrosis was studied electron-microscopically in 11 patients with collagen vascular disease and 26 patients with viral pneumonia. All patients exhibited progressive respiratory insufficiency and had abnormal pulmonary function test results. Endothelial cell cytoplasmic swelling and intracellular tubuloreticular structures were the dominant ultrastructural change in the lungs of both groups. Tubuloreticular structures were identified in peripheral blood lymphocytes in all patients with collagen vascular disease and in 2 with viral pneumonia. Tubuloreticular structures were not identified in the lung tissue from various control patients and in the lymphocytes from patients with idiopathic interstitial pulmonary fibrosis. We conclude that (1) the ultrastructural changes seen in viral pneumonia and collagen vascular-associated interstitial lung disease are essentially identical; (2) endothelial cell damage may be the primary pathologic change associated with both diseases; (3) tubuloreticular structures are seen in large numbers in lung tissue from patients with viral pneumonia and collagen vascular disease; (4) tubuloreticular structures are present in peripheral blood lymphocytes from all patients with collagen vascular disease.

Adult↗
PubMed1979

Melanotic schwannoma. Clinical and ultrastructural studies of three cases with evidence of intracellular melanin synthesis.

Three cases of intradural extramedullary melanotic nerve sheath tumors involving spinal nerves are reported. Clinical, roentgenographic, surgical, gross, histologic, and electron-microscopic findings were remarkably similar. Electron-microscopic study of the three neoplasms showed that the individual cells contained melanin pigment in all stages of maturation; in addition, there was prominent basal lamina, micropinocytotic vesicles, and other ultrastructural features consistent with Schwann cell derivation. The total clinical, operative, and morphologic picutre in these cases suggests that the tumors are true melanotic schwannomas capable of intracellular pigment production. The potential of such tumors for recurrence and metastasis is discussed.

Adult↗
PubMed1977

Nuclear bodies.

Explore the source record for details and available documents.

Adenocarcinoma↗
PubMed1977

Lymphomatoid granulomatosis: association with retroperitoneal fibrosis and evidence of impaired cell-mediated immunity.

Lymphomatoid granulomatosis is a non-neoplastic lymphoreticular disorder that usually presents as primary lung disease. A case of lymphomatoid granulomatosis associated with retroperitoneal fibrosis is reported. The retroperitoneal fibrous tissue contained the same variegated lymphoreticular infiltrate that formed the lung tumor, suggesting that the disease may have begun in the retroperitoneum. An extensive immunologic evaluation of the patient revealed impaired cell-mediated immunity.

Humans↗