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Biomedical subjects

D Coprean

Publications and source records attributed to D Coprean.

At least 19 recordsLinked to original sources
PubMed1989

Metabolic disturbances induced by organotins through subchronic treatment in chickens. First communication: growth dynamics, carbohydrate and protein metabolism.

Four organotin derivatives (tributyltin acid, dibutyltin chloride, triphenyltinchloride, and triphenyltin-bis (diethyl) dithiophosphate) were tested through subchronic treatment on 19 days old chickens. Growth dynamics as well as carbohydrate and protein metabolism were investigated, in order to evaluate their effects on metabolic activity. Biochemical liver and blood constituents revealed growth retardation and general depression of metabolic activity in experimental groups. Some correlations were found to exist chemical structure, dose use for compound, and effects. Butyltins were more toxic than phenylderivatives and their effects were proportionale to the dose.

Animals↗
PubMed1978

[The effect of various organochlorine pesticides on the immunologic reactivity of the white rat].

Wistar rats, aged 30 and 90 days, received Aldrin and Lindan treatment (8 ppm or 11 ppm) over 60 days, followed by inoculation of E. coli. The capacity of antibody formation was changed but not inhibited. Functional disorders occurred in the thymus (decline of nucleic acids), adrenal gland (decline of Vitamin C), and in the protein synthesis. The toxicity of even smaller Aldrin doses obviously was stronger than that of Lindan. The toxicity of either substance to younger animals was stronger than to individuals in more advanced age.

Adrenal Glands↗
PubMed1977

On the carbohydrate metabolism of pectoral muscle in the ontogeny of chicken.

1. Immediately after hatching, the pectoral muscle has a low glycogen content, and exhibits very low glycogen and high glucose and oxygen consumptions. 2. Drastic metabolic changes occur during the second day and again during the second week of life ("critical periods of the ontogenesis"); the above metabolic pattern is reversed. 3. The insulin sensitivity of the muscle is very low during these critical periods, and high between them. 4. The overall trend of metabolic ontogenesis in the pectoral muscle of the domestic fowl (non-flying bird) seems to have no functional but genetical determination.

Animals↗
PubMedDate not supplied

Biochemical modifications in the bursa of fabricius, thymus and adrenals of chickens injected with an anti-bursal serum.

Cornish-Rock chickens were given 0.3 ml anti-bursal serum in the pectoral muscle on the first day of life. Three days after serum administration, the modifications were evident both in the bursa of Fabricius and thymus (ponderal involution and decrease of RNA and glycogen contents). Pronounced thymo-bursal differences appeared at 13 days: in the bursa the values were normalized; in the thymus inverse modifications appeared as compared to the 3 days values. The modifications in the adrenals are in agreement with those in the lymph organs.

Adrenal Glands↗
PubMedDate not supplied

The hypoglycemic effect of "Hipogalegin".

In alloxan-induced diabetes in rats a marked increase in fasting glycemia was seen. The administration of "Hipogalegin" (0.45 g/kg b.w.; for one administration) led to a marked decrease of the glycemia in fasted diabetic animals: 40% of the diabetic animals subjected to this treatment survived and continued to survive even on the 94th day after diabetes was induced. Diabetic animals who were not given "Hypogalegin" died during the first two weeks after diabetes was induced.

Animals↗
PubMedDate not supplied

Hepatoprotector effect of Chrysanthemum balsamita extract in ethanol intoxicated rats.

Male Wistar rats weighing 200 +/- 10 g were intoxicated with ethanol 50% (1 ml/100 g b.w./, day, for 12 days) and concomitantly treated with hydroethanol extract of Chrysanthemum balsamita. An increase of liver glucose-6-phosphatase and phosphorylase a activities correlated with a liver glycogen breakdown as well as a decrease of glycemia were obtained in rats given ethanol 50%. It was found that Chrysanthemum balsamita extract counteracted ethanol effects and maintained at normal limit the metabolite parameters.

Alcoholic Intoxication↗
PubMedDate not supplied

Thiourea and methionine effects upon glucose and leucine absorption in chicken jejunum.

Administration of a unique dose of thiourea (7 mg per kg b.w.) in the 7th day of life to broiler chickens affects in different manners the jejunal absorption of glucose and that of leucine. Methionine supplementation of the fodder (1.5 g per kg) during 40 days affects--in an age-dependent manner--the glucose absorption, but not that of leucine.

Animals↗
PubMedDate not supplied

Thymic and suprarenalian response of Wistar rats following the administration of the humoral thymic factor (Leucotrofina) and of the cytostatic cyclophosphamide.

Leucotrofina administration in Wistar rats induced in thymus an increase of total protein content and of protein synthesis from 14C-leucine, simultaneously with a raise in the AlAT activity. Adrenal glands were not affected. Leucotrofina administration on the background of Cyclophosphamide induced modifications restored at normal values some of the thymic parameters (total protein content and RNA content) but the ascorbic acid content in the adrenals remained lowered.

Adrenal Glands↗