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Biomedical subjects

D Coprean

Publications and source records attributed to D Coprean.

23 records · Page 2Linked to original sources
PubMedDate not supplied

Biochemical modifications induced by Timorom in the liver carbohydrate metabolism of male and female rats.

A 90-day Timorom treatment of rats of both sexes modified some of the carbohydrate metabolism parameters. Some of the modifications were different in male and female rats. Glycogen storage was increased, while liver GPa activity was decreased in the male rats, but those modifications ran in the opposite direction in the female rats. In our opinion, these different reactions of male and female rats to Timorom (containing a nonselective beta-adrenergic blocking agent--timolol) depended on the different ways by which the glycogen phosphorylase system is activated. Many of the biochemical modifications, obtained after the Timorom treatment, disappeared at the end of the first post-treatment month.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

Effect of calcitonin on phosphorylase a and glucose-6-phosphatase activities in the hepatic particulate glycogen of rats.

A single dose of calcitonin (CT) (70 mU MRC/100 g body weight) was administered in 50 and 90 days old male Wistar rats. In both ages CT determined a rise of Phosphorylase a and glucose-6-phosphatase activity as well as an increased calcium accumulation at the level of liver particulate glycogen. In the rats receiving CT glycemia increased and the liver glycogen content decreased. With the exception of liver glycogen the other metabolic parameters studied were modified at the two ages in the same manner under the influence of the same dose of CT.

Animals↗
PubMedDate not supplied

Heart metabolic modifications induced by nifedipine treatment in normo- and hypertensive Wistar rats.

Male Wistar rats weighing 150 +/- 10 g at the beginning of the experiment were used. The animals were divided in to four groups: control group (C); Hypertensive group (H) (Hypertension induced by subcutaneously injecting desoxycorticosterone acetate: 14 mg/kg b. w./day and intragastric tubage administration of 30% sodium chloride: 3 g NaCl/kg b. w./day for 4 weeks); normotensive group receiving Nifedipine (N) (0.5 mg/Kg b. w./day); hypertensive group receiving Nifedipine (HN) (hypertension was induced as in group H and Nifedipine dose was as in group N). We observed that hypertensive status as well as Nifedipine treatment caused an increase of preference of rat heart muscle to utilize its glycogen as carbohydrate energy source instead of added glucose to incubation medium.

Adenosine Triphosphatases↗