Biomedical subjects

D Cuciureanu

Publications and source records attributed to D Cuciureanu.

4 recordsLinked to original sources

PubMedDate not supplied

[Clinical imaging correlations in lacunar infarcts].

PURPOSE: This paper is a study concerning the clinical-imagistic correlations in lacunar infarcts causes and associated lesions in these ones. We made an attempt to find out and emphasize the risk factors, causes and pathogenic mechanisms involved in lacunar syndromes. MATERIALS AND METHODS: We studied 138 patients with lacunar infarcts diagnosed by clinical examination and computer tomography. The investigation of risk factors evidenced arterial hypertension in 75 cases (54%). The clinical features of lacunar syndromes were: 1) pure motor stroke 41c; 2) pure sensory stroke 8c; 3) ataxic hemiparesis 9c; 4) dysarthria-clumsy hand 1c; 5) sensorimotor stroke 21c; 6) Landry syndrome 1c. RESULTS: We correlated the clinical manifestations and complementary investigations what enabled us to charge in determining of lacunar infarcts: focal microangiopathy-small artery disease (75c), cardio-embolic mechanism (12c), arterio-arteriolar embolic mechanism (15c). The risk factors and pathogenic mechanisms need more adequate research in order to find appropriate prevention and medical attendance.

Adult↗

PubMedDate not supplied

[Neurogenetics in Parkinson's disease].

The pathogenesis of Parkinson's disease, a progressive degenerative disorder of the central nervous system, remains obscure. 20% of cases are familial. The disorder may be due to a combination of genetic and environmental factors. Some monogenic forms of Parkinson's disease have been described. Many genetic studies explore whether a candidate gene may confer an increased risk for this disease. The search for a genetic susceptibility may lead to establish a preventive therapy.

Genetic Predisposition to Disease↗

PubMedDate not supplied

[Absence seizure--recent physiopathologic data].

The progresses in clarifying the normal and pathologic cellular and molecular mechanisms are reflected in the elucidation of the way some of the most common forms of generalized seizure--absence seizures--occur and are produced. Intrinsic properties of the thalamic neurons that give them the ability to release or preserve oscillatory, low-frequency neuronal discharges, and the thalamo-cortical feedback mechanism seem to explain the pathogenesis of absence seizures. The involvement of GABA receptors in the regulation of membrane calcium channels, as well as their genetically-induced changes are new pieces in the pathogenic puzzle.

Animals↗

PubMedDate not supplied

[Autonomic dysfunction in acute inflammatory demyelinating polyneuropathy].

Acute inflammatory demyelinating polyneuropathy (AIDP) is an autoimmune process that is characterized by progressive weakness, mild sensory changes and autonomic dysfunction. It is a rare disorder, afflicting about 1 person in 100,000. Yet, since the decline in the number of polio cases, it represents the most common cause of acute neuromuscular paralysis. AIDP is thought to arise as a result of the production of antibody to bacterial Campylobacter jejuni, sugar-containing surface antigen(s) that, due to molecular mimicry, cross-react with the myelin sheath and the axons of nerve cells. Antibody and/or cell mediated immune reactions are believed to produce degeneration of the nerve or interruption of neurotransmission. Autonomic dysfunction include: transient hypertension or, less often, hypotension, sinus tachycardia, bradycardia, urinary retention who usually improves in parallel with motor and sensory function. Our purpose was to study the disturbances of autonomic function of the patients with acute idiopathic demyelinating polyneuropathy. We had studied 36 patients with AIDP admitted in I-st Clinic of Neurology, Iassy, between 1998 and 2002. Analyzing the evolution of these autonomic disturbances we observed the early onset together with motor symptoms, tachycardia and tachypnea was more persistent and a real vital risk factor.

Adult↗