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Biomedical subjects

D Cullen

Publications and source records attributed to D Cullen.

67 records · Page 4Linked to original sources
PubMed1986

Epidural morphine provides postoperative pain relief in peripheral vascular and orthopedic surgical patients: a dose-response study.

A randomized double-blind study compared the dose-response relationship of epidural morphine for postoperative pain relief in two groups of patients whose surgical procedures would result in either moderate (femoral-popliteal bypass) or severe (total knee replacement) postoperative pain. Preservative-free morphine sulphate in doses of 0, 2, 5, or 10 mg in a volume of 10 ml saline were administered via lumbar epidural catheters. The epidural morphine was administered 1 hr after the last dose of intraoperative local epidural anesthetic in an effort to achieve a pain-free postoperative course. A significant relationship existed between the dose of epidural morphine and both time to first required pain medication and 24-hr weighted pain score. Five mg epidural morphine provided significant improvement in postoperative analgesia compared with the control in both groups. Further enhancement of analgesia occurred with 10 mg; however, late respiratory depression, demonstrated by an increased resting PaCO2 10 hr after administration, was seen only with the 10-mg dose in both surgical groups. Minor complications such as nausea, vomiting, pruritus, and urinary retention were uncommon and did not appear to be related to dose. We found that 5 mg epidural morphine provided long-lasting postoperative analgesia without serious adverse effects after peripheral vascular and orthopedic surgery.

Adult↗
PubMed1983

Heterokaryosis in Fusarium tricinctum and F. sporotrichioides.

Heterokaryons were formed in intra- and interspecific crosses between Fusarium sporotrichioides and F. tricinctum auxotrophs. Segregant homokaryons were evaluated for trichothecene toxin production in culture. Results were consistent with nuclear control of toxin synthesis. The sexual compatibility of auxotrophs and 30 additional F. tricinctum sensu Snyder & Hansen strains was tested. Perithecial production was restricted to crosses between Florida isolates pathogenic to English ivy (Hedera helix). The linkage of several auxotrophic markers was determined by analysis of progeny of certain crosses. No T-2 toxin was produced by sexually compatible F. tricinctum isolates.

Crosses, Genetic↗
PubMed1982

New process for T-2 toxin production.

Strains of Fusarium produced high levels of T-2 toxin when cultured on certain media absorbed into vermiculite. Modified Gregory medium was nutritionally complex (2% soya meal, 0.5% corn steep liquor, 10% glucose) and, when inoculated with the appropriate fungal strain, yielded maximum T-2 toxin within 24 days of incubation at 19 degrees C. On Vogel synthetic medium N (H. J. Vogel, Microb. Genet, Bull. 13:42-43, 1956) supplemented with 5% glucose, optimal toxin levels were synthesized after incubation for 12 to 14 days at 15 degrees C. Fusarium tricinctum T-340 produced 714 and 353 mg/liter on modified Gregory medium and Vogel synthetic medium N plus 5% glucose, respectively. Improved analytical procedures were developed and involved aqueous methanol extraction, purification by liquid-liquid partitions, and gas-chromatographic quantitation.

Chromatography, Gas↗
PubMed1978

Autonomic function tests in diabetes mellitus.

Five tests of autonomic function were evaluated in a group of twenty-five diabetics. The Valsalva ratio proved to be the most valuable single indicator of generalised autonomic dysfunction, whilst the blood pressure response to sustained handgrip, the pupillary response to a dilute solution of methacholine and the fall in blood pressure on standing, all proved to be less valuable as indices of autonomic neuropathy either when considered individually or when taken together. The cold pressor test was shown to be of no value in the assessment of patients with autonomic neuropathy. It is suggested that of those examined the Valsalva procedure is the most valuable simple outpatient test for autonomic neuropathy.

Adult↗
PubMed1976

Survival at sea.

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Humans↗
PubMedDate not supplied

Household smoking restrictions and adolescents' exposure to environmental tobacco smoke.

BACKGROUND: Reducing adolescents' exposure to environmental tobacco smoke (ETS) is an important public health goal. This paper identifies the linkage between young people's exposure at home and household smoking restrictions, and suggests the promotion of such restrictions as a strategy to reduce health risks. METHODS: Data are from the 1993 Massachusetts Tobacco Survey, a telephone survey of 1,606 adolescents. RESULTS: Seventy-eight percent of adolescents reported exposure to ETS during the preceding week. Reported hours of exposure at home were associated with the number of adult smokers in the household (P < 0.001). Fifty-three percent of teens who lived with smokers reported no smoking restrictions for family members, 22% reported designated smoking areas, and 25% reported smoking bans. Among those households, smoking restrictions for family members were associated with significant reductions in mean hours of ETS exposure reported: no restrictions were associated with 33.2 hr of exposure during the prior week, designated smoking areas--12.7 hr, and household smoking bans--2.4 hr. Restrictions on visitor smoking were associated with significant reductions in home ETS exposure for teens who lived with nonsmokers, but had no independent effect among teens who lived with smokers. CONCLUSIONS: Health risks experienced by adolescents living with adult smokers can be substantially reduced by household smoking restrictions.

Adolescent↗
PubMedDate not supplied

How healthy are you?

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Alcohol Drinking↗