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Biomedical subjects

D Dudek

Publications and source records attributed to D Dudek.

At least 37 records · Page 2Linked to original sources
PubMed1998

[Stents for treatment of transluminal percutaneous coronary angioplasty (PTCA) complications].

UNLABELLED: This study describes initial results of stent implantation in bailout situations in 38 patients with obstructive dissection after percutaneous transluminal coronary angioplasty (PTCA). Before stent introduction 1.8% of all patients after PTCA required emergency bypass grafting (CABG) because of postprocedural complications. In 1997 the rate of such emergency operations decreased to only 0.5% (p < 0.05). The success rate of stent deployment in patients included in the study was 95%. Mean final inflation pressure used for stent deployment was 12.0 +/- 2.3 atm. After stent implantation average residual stenosis was -0.81 +/- 5.75%. Of the 38 patients, 15 (40%) were treated before stent implantation with prolonged inflations with perfusion catheter. Bailout stenting was performed in 10 (25%) patients undergoing PTCA for restenotic lesions. The stents were placed in the left anterior descending coronary artery in 26 patients (69%), left circumflex coronary artery in 3 patients (8%), and in the right coronary artery in 9 patients (23%). Before bailout stenting 28 patients (75%) presented with type C and D dissection. One patient (2.5%) developed acute stent thrombosis. No episodes of subacute stent thrombosis were noted. During six-months clinical follow up no death and no Q-MI were observed. Angiographic follow up restenosis rate was 13/30 (43%), predominantly in patients treated with prolonged perfusion balloon inflations before stent implantation. The incidence of repeated PTCA and elective CABG due to restenosis was 12/30 (40%) and 1/30 (3%), respectively. There were no vascular complication at the puncture site. IN CONCLUSION: the introduction of coronary stenting has provided an excellent non-surgical modality for treatment of imminent or acute vascular closure complicating coronary angioplasty.

Adult↗
PubMed1998

Influence of an early adrenergic blockade on thrombotic infarct size and myocardial metabolism.

To evaluate the extent to which the protective effect of metoprolol was accompanied by changes in myocardial oxygen consumption and metabolism, thrombotic occlusion of coronary artery followed by infusion of metoprolol or placebo was performed in twenty four German Shepherds. To restore a coronary blood flow rt-PA was administered. Plasma levels of oxygen, glucose, lactic acid, non esterified fatty acids, triacylglyceride and adenosine breakdown products were measured before and at the end of the occlusion and in the early and late reperfusion periods. Regional myocardial blood flow was measured by means of radioactive tracer microspheres. Infarct size was estimated after perfusion and staining of excised hearts with Evans blue. Plasma levels of metoprolol were determinated before the end of occlusion and during reperfusion and therapeutic concentrations were confirmed. The infarct size was smaller in dogs receiving metoprolol (21.6 +/- 20.7 vs 43.0 +/- 17.3% p. < 0.02). Coronary collateral blood flow was greater in metoprolol than in placebo dogs (18.68 +/- 7.58 vs 11.05 +/- 6.10 ml/min/100g, p. < 0.01). As a consequence of myocardial ischemia a shift toward carbohydrate utilization, the myocardial lactate release and the accompanying symptoms of diminished myocardial lipid uptake were observed. A washout of adenosine degradation products during early reperfusion was also noticed. In beta 1 blocked animals the reduction of myocardial oxygen consumption and preserved myocardial uptake of lactate and non esterified fatty acids were documented.

Adenosine↗
PubMed1996

Determinants of depressed left ventricular ejection fraction in pure mitral stenosis with preserved sinus rhythm.

BACKGROUND AND AIM OF THE STUDY: Although depressed left ventricular ejection fraction is present in a considerable proportion of subjects with pure mitral stenosis (MS), its mechanisms are not clearly identified. The purpose of this study was to identify determinants of depressed ejection fraction in young patients with isolated mitral stenosis in sinus rhythm. METHODS: We retrospectively analyzed 320 records of patients with MS (mitral valve area < or = 2.0 cm2) who underwent invasive diagnostic procedure in our center. Of these 39 subjects aged 20-40 years with isolated MS in sinus rhythm were selected for the final analysis. RESULTS: An ejection fraction not exceeding 50% was found in 12 patients (group A). When comparing group A to the remainder (group B), group A patients had lower left ventricular end-diastolic volume indices (60.5 +/- 21.6 ml/m2 vs. 76.1 +/- 16.1 ml/m2, p = 0.02) and stroke volume indices (28.0 +/- 10.4 vs. 47.9 +/- 12.0, p < 0.001). No significant differences between the groups in patients' age, end-systolic volume index, mitral valve area, mean transmitral gradient, left-sided cardiac pressures, pulmonary wedge pressure, systemic vascular resistance, and cardiac output were found. Indices of left ventricular isovolumic contraction and relaxation as well as end-systolic indices of left ventricular function were also comparable. Group A had significantly higher pulmonary vascular resistance, pulmonary artery pressures, and higher heart rate. An approximate index of left ventricular compliance was significantly lower in group A with similar left ventricular minimal and end-diastolic pressures. CONCLUSIONS: Depressed ejection fraction in pure mitral stenosis with preserved sinus rhythm seems attributable to left ventricular underfilling that appears to be precipitated by other factors in addition to a narrowed mitral orifice, e.g. decreased passive left ventricular compliance and/or altered interventricular interactions.

Adult↗
PubMed1990

The influence of PRL, LH alone and in combination upon progesterone secretion by porcine luteal cells in aggregate culture.

Corpora lutea removed from ovarian of cycling pigs in early luteal phase (1-3 days) were used. After enzyme dispersion the luteal cells were suspended in medium M 199 supplemented with 10% of calf serum. Cultures were carried out in triplicate and incubated at 37 degrees C for 24 h. After that time the following hormones were added to the culture medium; 100 ng LH, or 100 ng PRL or 100 ng LH plus 100 ng PRL. The cells were incubated with hormone for 6, 12, 24 and 48 h. LH added to the medium resulted in the increase of progesterone secretion (P less than 0.05) only during 6 h incubation (140% of control progesterone). Stimulatory effect of PRL was observed only after 12 h incubation (300% of control progesterone; P less than 0.001). The addition of LH plus PRL decreased progesterone secretion after 6 h incubation (33.3% of control progesterone; P less than 0.05), a little stimulatory effect being observed after 24 h incubation (141% of control progesterone). This study confirmed the results obtained with monolayer cultures previously described. PRL appeared to be a luteotrophic hormone which is responsible for the increase of progesterone secretion by the early developing corpus luteum of pig. From these data it was concluded that luteal cells may require either LH or prolactin but not both at a time to sustain higher level of progesterone secretion.

Animals↗
PubMedDate not supplied

[Children and parental depression. An investigation on adult offspring of depressed patients].

The aim of our study was to assess the perception of parental depression by their adult offspring. Twenty nine offsprings aged 22.5 +/- 3.9 years were examined with the use of Parental Bonding Instrument, Beck Depression Inventory, Resenberg Scale, Hopelessness Scale, Automatic Thoughts Questionnaire and our own semistructured inventory. The offsprings of depressed patients reported negative impact of the illness on various aspects of life, especially when mother was ill. Surprisingly, the offsprings did not reveal disturbances in their thinking style, neither did they have depressive symptoms.

Adolescent↗
PubMedDate not supplied

[Religiosity and intensity of endogenous depression symptoms. A follow-up study].

The aim of our study was to determine if the quality of remission in unipolar affective disorder correlates with patient's religiosity. We have investigated 63 patients who were hospitalised in the Department of Psychiatry CMUJ between 1991 and 1997. The quality of remission has been assessed by Beck Depression Inventory (BDI), Rosenberg Self-esteem Scale (RS), Automatic Thoughts Questionnaire (ATQ), Hopelessness Scale (HS). Religiosity has been tested by the Scale of Individual Religiosity, and Religious Life Inventory. Patients were also assessed with the use of our own questionnaire, answering the following questions: 1. Do you believe?, 2. Does the disease influence the faith?, 3. Does your faith help in the disease?. Religiosity did not correlate with the quality of remission in depression in a statistically significant manner. There is only one statistically significant correlation: patients who answered positively the question number 3 (41 patients), have better remission. It is impossible to describe simple correlation between religiosity and remission in unipolar affective disorder. Patients who found their faith helpful have better remission.

Depressive Disorder↗
PubMedDate not supplied

Is serum copper a "trait marker" of unipolar depression? A preliminary clinical study.

Depression is not a homogenous illness and is diagnosed in only one in three persons suffering from this disorder. Besides psychological-psychiatric diagnostic methods (e.g. Hamilton's, Beck's rating scales), some biochemical measures have been introduced as markers of depression. However, the sensitivity of even the best characterized dexamethasone suppression test is as low as 40-50%. A search for better markers is continuously in progress. In the present study, we investigated alterations in serum copper concentrations in depressive patients before, during and after antidepressant treatment and compared these values with the concentrations in healthy volunteers. The serum copper concentration in depression is significantly higher (by 21%) than in the control. However, effective antidepressant treatments (which reduced symptoms by ca. 50% measured by Hamilton Depression Rating Scale) did not affect (did not normalize) this increased copper concentration. The present data indicate that serum copper is a "trait marker" (remains constant regardless of successful treatment) of unipolar depression.

Adult↗
PubMedDate not supplied

[Depressive disturbance and quality of life in patients with coronary artery disease].

The aim the study was to evaluate the impact of mood disturbances on the subjective quality of life in patients with coronary artery disease after an effective angioplasty. The study covered 100 patients with the optimum result of PTCA. Their condition was evaluated one day before and four weeks after angioplasty. Significant differences in the subjective quality of life assessment were detected depending on the occurrence and dynamics of depressive symptoms. The authors postulate evaluation of psychological state and introduction of anti-depressive therapy in patients with coronary artery disease subjected to revascularisation.

Coronary Artery Bypass↗
PubMedDate not supplied

[Development and application of cognitive therapy in affective disorders].

Cognitive psychotherapy was originally created for out-patient treatment of mild and moderate, non-psychotic, unipolar depressive disorder. Further development of the therapy resulted in its use in various mental disorders. Cognitive therapy has also been used in wide spectrum of affective disorders, including severe, endogenous depression, chronic depression, bipolar disorder and suicidality. Therapeutic programs involve individual, group, family and marital cognitive psychotherapy. Effectiveness and clear conceptualization encourages to wide use of this kind of therapy.

Cognitive Behavioral Therapy↗
PubMedDate not supplied

Plasma levels of interleukin-6, interleukin-10, and interleukin-1 receptor antagonist in depression: comparison between the acute state and after remission.

There is now some evidence that major depression is accompanied by an immune response with an increased production of pro-inflammatory cytokines. The aim of the present study was to examine serum level of cytokines: interleukin-6 (IL-6), which is considered pro-inflammatory one and anti-inflammatory cytokines: interleukin 10 (IL-10), and interleukin-1 receptor antagonist (IL-1Ra) in acute clinical state of depression and after 6-week antidepressant treatment. Serum IL-6, IL-10, IL-1Ra levels were higher in the subjects with major depression than in normal controls although these results were not statistically significant. The mean score according to the Hamilton Depression Rating Scale (HDRS) in the patients significantly decreased during the 6 weeks of the study, demonstrating an overall improvement. Successful antidepressant treatment had no significant effect on serum level of this cytokines.

Analysis of Variance↗
PubMedDate not supplied

[Sexual functioning of patients with major depression. Pilot study].

Disturbances in sexual functioning in patients with endogenous mental disorders are frequently reported. The aim of the study was to estimate the occurrence of sexual disfunctions in patients hospitalised for major depression (unipolar affective disorder). The investigations covered 53 persons remaining in stable partnership. Apart from the assessment of psychological state, depressive symptoms and the course of treatment, we analysed the quality of relations with the partner, sexual satisfaction, willingness to and frequency of sexual intercourse, satisfaction with oneself as a sexual partner. The obtained results indicate that sexual problems must not be neglected in treatment of depressive patients.

Adult↗
PubMedDate not supplied

[Pharmacotherapy for depression in patients with myocardial ischemia].

The comorbidity of depression and heart diseases is an important but still devaluated clinical problem. Mood disorders in those ill with cardiac ischaemic disease significantly worsen the predictive mortality and quality of life. It may be predicted that adequate therapy of depression could have a positive effect on the long term course of IHD. Careful analysis of indications and contradictions as well as the application of new generation drugs allows for safe therapy. Evident benefits of appropriate treatment of depression in this group of patients, deny the old thesis on the damage of antidepressive drugs on the cardio-vascular system.

Antidepressive Agents↗
PubMedDate not supplied

Zinc exhibits an antidepressant-like effect in the forced swimming test in mice.

The effects of zinc, the NMDA receptor inhibitor, were studied in the forced swimming (Porsolt's) test in mice. Zinc (ZnSO4) at a dose of 30 mg/kg (but not at a dose of 10 mg/kg), similarly to imipramine (30 mg/kg), reduced the immobility time in that test. Moreover, zinc at both doses reduced the locomotor activity. The obtained results indicate that zinc induces an antidepressant-like effect in the forced swimming test. Since zinc reduces the locomotor activity, this antidepressant-like effect is not related to the alteration of general activity.

Animals↗