Biomedical subjects

D F Kinane

Publications and source records attributed to D F Kinane.

114 records · Page 7Linked to original sources

PubMed1983

Blood group, secretor status, and susceptibility to infection by Neisseria gonorrhoeae.

To determine whether the presence or absence of anti-B isohaemagglutinin in individuals of blood group B increases their susceptibility to gonococcal infections 567 new patients attending a sexually transmitted disease clinic were screened for blood group and secretor status. Of the patients with blood group B, 20.1% had gonorrhoea and 12% had not. A higher percentage (20.9%) of patients with no anti-B isohaemagglutinin had gonorrhoea compared with those without (12.1%). There was, however, no synergy between the absence of anti-B isohaemagglutin and nonsecretion of water-soluble blood group B antigen. Further research is needed to determine the underlying host-parasite interactions responsible for the increased susceptibility to gonorrhoea in these individuals.

ABO Blood-Group System↗

PubMed1983

ABO blood group and susceptibility to gonococcal infection. I. Factors affecting phagocytosis of Neisseria gonorrhoeae.

The effect of opsonization of Neisseria gonorrhoeae by isohaemagglutinins from normal serum on attachment to human polymorphonuclear leukocytes (PMN) was investigated. No significant differences between sera from blood groups O, A, B or AB were found. Differences in attachment of gonococci were related to differences in lipopolysaccharide detected by sensitivity to R-type pyocines of Pseudomonas aeruginosa. Non-pilate variants of each test strain markedly stimulated nitroblue tetrazolium (NBT) reduction in PMN, but their pilate variants were essentially inactive in the NBT test.

ABO Blood-Group System↗

PubMed1983

Blood groups and susceptibility to gonococcal infection. II. The relationship of lipopolysaccharide type to gonococcal sensitivity to the bactericidal activity of normal human serum.

This study examines the bactericidal activity of normal human sera from individuals of blood groups A and B for gonococcal strains with simple and complex lipopolysaccharides (defined by pyocin-sensitivity) isolated from localised and disseminated infection. The bactericidal activity did not depend on A or B isohaemagglutinins. Resistance to normal human serum exhibited by strains from localised infections appeared to be due to lack of part of the lipopolysaccharide antigen, whereas resistance of strains from disseminated infection appeared to depend on a separate mechanism yet to be defined.

ABO Blood-Group System↗

PubMed1983

ABO blood groups and susceptibility to gonococcal infection. III. Role of isohemagglutinins in increased association of Neisseria gonorrhoeae to monocytes from blood group B individuals.

The association of human monocytes of different ABO blood groups with gonococci was examined under various conditions. Blood group B monocytes in the presence of autologous heat inactivated serum (HIS) showed increased association over monocytes of the other ABO groups with their autologous sera. No statistically significant trends in ABO monocyte association were noted for assays carried out in the absence of autologous HIS. Absorptions of isohemagglutinins from sera reduced the gonococcus-monocyte association level to that of controls.

ABO Blood-Group System↗

PubMed1982

ABO blood group, secretor state, and susceptibility to recurrent urinary tract infection in women.

ABO blood group and secretor state was determined in 319 women with recurrent urinary tract infection and compared with those of a control group of 334 women of similar age ranges. Women of blood groups B and AB who are non-secretors of blood group substances showed a significant relative risk of recurrent urinary tract infection of 3.12 (95% confidence limits, 1.49 and 6.52) in comparison with other types. This appears to be a genuine example of synergy in which absence of anti-B isohaemagglutinin and secretor substances combines to give an increased risk of recurrent urinary tract infection. Determination of blood group and secretor state may provide additional information in identifying those at risk.

ABO Blood-Group System↗

PubMed1982

Phagocyte recognition of Neisseria gonorrhoeae.

Human monocytes show an increased ability to bind pilate rather than non-pilate gonococci. Polymorphonuclear leucocytes (PMN) do not discriminate between pilate and non-pilate variants. PMN, however, bind appreciably more gonococci (either pilate or non-pilate) than monocytes. The results help to explain the role of pili on gonococci as virulence factors and in the immune response.

Fimbriae, Bacterial↗