Biomedical subjects
Publications and source records attributed to D Fabris.
Two cases of osteoblastoma of a rib associated with progressive scoliosis are reported. The unusual localization of the neoplastic lesions and their close relationship to the lateral deviation of the spine suggest an etiologic basis for these patients' scoliosis. The need for early diagnosis and surgical excision of the rib lesion in the treatment of scoliosis resulting from osteoblastoma of a rib is stressed.
The authors advance the theory that there are two distinct groups of idiopathic scoliosis, of different aetiology and with different potential for development. This is based on the relationship between vertebral rotation and wedge deformity of the vertebral bodies. The rotatory type can be identified, to a statistically significant extent, in the initial phases of thoracic scoliosis. In order to test this hypothesis, we therefore confined our study to cases in which the initial Cobb angle was less than 20 degrees.
The authors describe a case of craniocleidopelvic dysostosis in a patient with progressive scoliosis. They attribute the pathogenesis of the vertebral deformity to imbalance of the shoulder girdle muscles and dysplasia of the vertebral metameres. They agree with the majority of authors in regarding craniocleidopelvic dysostosis as a specific clinical manifestation of a complex hereditary syndrome.
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A case of nonosteogenic fibroma of the neural arch associated with scoliosis is reported. The unusual location of the neoplastic lesion and its close relationship with the lateral deviation of the spine are discussed. The necessity for accurate, early etiologic diagnosis is stressed. Early resection of the lesion led to resolution of the spinal curvature and pain.
Variations in the metabolism of collagen of patients with idiopathic scoliosis were studied by measuring the quantity of total hydroxyproline excreted in the urine in 24 hours. Results were correlated with the degree of deviation and the degree of rapid vertebral growth. From the results a hypothesis can be formulated that scoliosis is caused by altered metabolism of connective tissue with increased destruction of collagen demonstrated by the increased excretion of urinary hydroxyproline.