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Biomedical subjects

D Geltner

Publications and source records attributed to D Geltner.

At least 55 records · Page 3Linked to original sources
PubMed1987

Polymorphism of human immunoglobulin VH genes: a possible marker of autoimmune disease.

Human DNA from 11 individuals was analysed by Southern blot for the immunoglobulin genes coding for the heavy chain variable region (VH). The analysis included two probes detecting the genes of subgroup VHII and VHIII. The VH genes pattern shows very little polymorphism whereas the VHIII genes showed a significant polymorphism. When DNA from four patients with Graves' disease was analysed, a VH band was found in DNA of all patients analysed, and of 50 per cent of SLE patients, whereas only 36 per cent of healthy people contained this VH band. This may serve as a new tool to study genetic markers of autoimmune diseases.

Autoimmune Diseases↗
PubMed1987

Disruption of the symphysis pubis and fatigue fractures of the pelvis in a patient with rheumatoid arthritis. A case report.

A 40-year-old woman, who suffered from severe rheumatoid arthritis causing avascular necrosis of the femoral head and protrusio acetabuli of the right hip, developed a severe spontaneous disruption of the symphysis pubis concomitant with a stress fracture of the left ilium adjacent to the left sacroiliac joint. After successful total hip arthroplasty, the symphysiolysis improved, but a new stress fracture of the left superior pubic ramus developed. Fourteen months after operation both stress fractures are healed. Altered hip and pelvic girdle mechanics acting on osteoporotic bone may account for this sequence of events.

Acetabulum↗
PubMed1986

Gold-induced ileitis.

We describe a patient with rheumatoid arthritis who developed severe ileitis after being treated with gold salts; the patient responded to elimination of the gold therapy and to BAL.

Arthritis, Rheumatoid↗
PubMed1981

The effect of combination therapy (steroids, immunosuppressives, and plasmapheresis) on 5 mixed cryoglobulinemia patients with renal, neurologic, and vascular involvement.

A prospective clinical study evaluated the effects of combined chemotherapy, steroids and plasmapheresis on 5 patients with mixed cryoglobulinemia with renal or neurologic and vasculitic manifestations. Treatment included prednisone (1mg/kg/day), chlorambucil (white blood cell count at greater than 3,000/mm3), and plasmapheresis (1 to 3 liters/week). There was healing of cutaneous ulcers (3/3), improvement in renal function (4/4), and diminution of purpura (2/2), but little improvement in peripheral neuropathy. Complications included leukopenia, perineal ulcers, and osteomyelitis.

Aged↗
PubMed1980

Human monoclonal macroglobulins with specificity for Klebsiella K polysaccharides that contain 3,4-pyruvylated-D-galactose and 4,6-pyruvylated-D-galactose.

Two human IgM myeloma proteins, IgMWEA and IgMMAY, were found to react with agar and Klebsiella polysaccharides that contain pyruvylated D-galactose (DGal). Quantitative precipitin data and precipitin inhibition studies with methyl alpha- and beta-glycosides of 4,6-pyruvylated-D-galactose showed their combining sites to be different, although each was directed against the pyruvylated-D-Gal, one reacting most specifically with Klebsiella polysaccharides with terminal nonreducing beta-linked 2,4 pyruvylated-D-Gal, whereas the other reacted equally well with Klebsiella polysaccharides that contain 3,4 beta-linked and 4,6 alpha-linked terminal nonreducing pyruvylated-DGal. Inhibition studies showed that both sites are directed toward one of the two space isomers of 3,4- or 4,6-pyruvylated DGal, the form in which the methyl group of the pyruvate is equatorial, or endo, and its carboxyl group axial, or exo, to the plane of the acetal ring. Coprecipitation studies showed the combining site of IgMWEA to be located on an (Fab')2 fragment and not on the (Fc)5mu fragment. The monoclonal peak in the serum of IgMMAY was specifically precipitated by Klebsiella polysaccharide. Myeloma proteins with specificities of this type may occur with reasonable frequency in humans and may be a consequence of clonal expansion from inapparent infection, carrier states, or disease produced by various Klebsiella organisms.

Adult↗
PubMed1980

Antiidiotypic activity in the IgM fractions of mixed cryoglobulins.

To search for human antiidiotypic antibodies, cryoglobulins from 11 patients with mixed cryoglobulinemia, 7 of whom had evidence of prior hepatitis B virus infection were separated on Sephadex G-200. Each of the IgM, 8 of which were IgM kappa, was tested with the F(ab')2 fragments prepared from each of the IgG fractions in a solid phase assay by using binding of 125I Staph A protein after the addition of rabbit anti-IgM. Unlike rabbit anti-Fab, which reacted approximately to the same extent with all F(ab')2 fragments, the IgM varied in their binding to F(ab')2 fragments, reacting with 2 to 10 antigens. Nine reacted with their autologous antigen and in 5 instances autologous reactivity exceeded that with heterologous F(ab')2 fragments. Reactivity was not related to prior exposure to HBV. Though absorption with Cohn fraction II F(ab')2 fragments generally abolished reactivity, 1 IgM protein continued to react with nine F(ab')2 fragments and 4 others with the F(ab')2 fragment from a single patient. Even when they contained only a single type of kappa-chain, the IgM appeared to contain multiple antibodies since absorption with solid phase Fc fragments or IgG removed anti-Fc rheumatoid factor activity but failed to affect binding to F(ab')2 fragments. Five of 7 IgM were able to bind the Fv region of a monoclonal IgM kappa-protein. Some of the anti-Fab antibodies were directed against idiotypes since addition of HbsAg to F(ab')2 fragments from HBsAb-positive IgG resulted in a marked decrease in binding of the IgM fraction in 6 out of 7 studies, whereas no decrease was noted in 6 experiments with F(ab')2 fragments that were HBsAb negative. The possible existence of antibodies against other idiotypes or other determinants in the Fab region cannot be excluded.

Absorption↗
PubMed1980

Malabsorption following aorto-femoral bypass.

A case of malabsorption which developed after aortofemoral bypass surgery is described. Barium enema showed ischemic changes, and postoperative arteriography revealed marked reduction of the peripheral vascular bed of the mesenteric arteries. Malabsorption probably developed as a consequence of mesenteric ischemia, aggravated by the surgical procedure, the so-called aorto-iliac steal syndrome.

Aged↗
PubMed1978

Acute lymphoblastic leukemia. Its occurrence with hypereosinophilic syndrome' and bilateral spontaneous pneumothorax.

A patient with acute lymphoblastic leukemia had an unusual prodrome, including clinical features of "hypereosinophilic syndrome," pulmonary infiltrates, and bilateral spontaneous pneumothorax, which preceded the onset of leukemia by four months. The mechanism for the production of eosinophilia may have been related to the production of eosinopoietic factors by the leukemic cells.

Adolescent↗
PubMed1976

Quinidine hypersensitivity and liver involvement. A survey of 32 patients.

Thirty-two of 487 patients who received quinidine between the years of 1970 and 1974 in the departments of medicine at Hadassah University Hospital developed hypersensitivity reactions. Ten of the 32 patients had clinical and biochemical manifestations of liver invlovement. In 4 patients liver biopsy showed granulomatous hepatitis. It is therefore concluded that quinidine-induced hepatitis is a relatively common side effect of this drug.

Chemical and Drug Induced Liver Injury↗