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D Geltner

Publications and source records attributed to D Geltner.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Attenuation of anaphylactic shock and related mortality in guinea-pigs after administration of a potent protein kinase inhibitor, K252a.

We examined whether protein kinases have a role in the expression of anaphylactic shock (AS). Guinea-pigs sensitized to ovalbumin were administered i.p. saline (control) or 10 micrograms/kg K252a, a potent protein kinase inhibitor, 30 min before challenge. The development of AS and mortality was observed for the next 2 h. In the K252a-treated group the incidence of AS fell to 53% from 100%, the maximum intensity was 62% less than the control, and mortality dropped to 16% from 50% of the animals. We suggest that protein kinases are involved in the expression of AS, and that inhibitors of these enzymes may protect against the symptoms of AS and allergy.

Anaphylaxis↗
PubMedDate not supplied

A comparison between partial and complete ligation of the inferior vena cava for the prevention of recurrent pulmonary embolism.

Interruption of the inferior vena cava is the definitive surgical measure for the control of pulmonary emboli. There is, however, some controversy as to whether the preferred treatment is complete or partial interruption. This report summarizes our experience with 49 patients who underwent partial ligation, using a technique developed in our Department, and 66 patients, who underwent complete ligation of the inferior vena cava. The incidence and severity of sequelae due to venous stasis in the legs were less in the group that underwent partial interruption.

Adult↗
PubMedDate not supplied

Systemic lupus erythematosus in 49 Israeli males: a retrospective study.

Forty-nine male SLE patients, diagnosed and followed in seven medical centers in Israel between 1954 and 1983, were studied and analyzed retrospectively in order to determine whether the disease in males was clinically different from that reported in females both in Israel and in the world literature. The primary clinical and laboratory manifestations, the severity of the disease at the onset or at any time during the course of the disease, and the 1-15 year survival rates were not different from those described before in female SLE, although neurological involvement, nephritis, thrombocytopenia, vasculitis and hepatosplenomegaly were more prevalent in our series. However, more than half of the male patients (53%) had a benign course of disease characterized by long remissions requiring minimal or no medication. Long-term remission of serious renal involvement was observed completely in 14 and partially in 5 out of 33 patients. These results suggest that the male sex might alter the clinical course of SLE.

Adolescent↗