Delta hepatitis in North Carolina: learning from a patient.
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Adult↗
Biomedical subjects
D J Jacob
Publications and source records attributed to D J Jacob.
A monoclonal IgG4 (lambda) with factor V inhibitory activity.
A monoclonal IgG4 (lambda) with inhibitory activity to human coagulation factor V was isolated from the serum of a patient with a fatal hemorrhagic diathesis by using a combination of DE-52 ion exchange chromatography and isoelectric focusing techniques. Using the criteria for defining a monoclonal immunoglobulin of restricted mobility on protein electrophoresis, immunoelectrophoresis, and isoelectric focusing, as well as neutralization with class, subclass, and light chain type antisera, we are the first to demonstrate a factor V inhibitor as a monoclonal IgG4 (lambda) detectable in serum or plasma.
Chromatography, Ion Exchange↗