Heel pain as the inaugural manifestation of metastatic prostate cancer.
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Biomedical subjects
Publications and source records attributed to D Jaubert.
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The authors of this paper present a retrospective analysis of 84 cases of hairy cell leukaemia diagnosed over the past ten years in two haematology departments. Cutaneous manifestations are noted on 47 occasions, 58% of infectious origin with 60% of these infections due to bacterial agents, results which are in relatively close accord with those of the Mayo Clinic. Since no cases of necrotic angeitis or neutrophilic dermatosis are reported, the considerable number of publications concerning these affections give a poor indication of their rarity. Prospective studies will be required to evaluate the incidence of spinocellular carcinoma and melanoma, while specific lesions are only infrequently encountered and do not appear to bear the same unfavourable prognosis as in other haemopathia.
In order to assess the central motor pathways of HIV-infected patients motor evoked potentials were recorded on the upper limbs after transcranial and cervical magnetic stimulations and compared with peripheral conduction velocities. Motor evoked potentials were measured on both sides of 28 patients, mostly at the AIDS stage. Our results showed that although peripheral neuropathy was often found, central motor pathways did not appear, at the level they were tested, to be directly or indirectly damaged by the virus. On the contrary, some hyperexcitability seemed to be present.
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The authors report 2 cases of primary melanoma of the esophagus, and describes the clinical, endoscopical, radiological and histological features from these exceptional tumors. Prognosis is very poor, despite various therapeutical possibilities.
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The authors report two cases of malignant melanoma associated with hairy cell leukemia. Skin neoplasia preceded hematological malignancy in the first observation. Among reports concerning the association of malignant melanoma with hematological diseases, chronic lymphocytic leukemia, Hodgkin's lymphoma and non Hodgkin's lymphoma are preponderant. Epidemiological studies would be of value to predict the expected risk of malignant melanoma in hairy cell leukemia.
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