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Biomedical subjects

D Jaubert

Publications and source records attributed to D Jaubert.

54 records · Page 3Linked to original sources
PubMed1991

[Massive necrotizing adenitis complicating a disseminated herpes simplex virus 2 infection in chronic lymphoid leukemia].

We report a case of a 68 years old male patient treated for chronic lymphocytic leukaemia, presenting a right inguino-crural tender lymphadenopathy with periadenitis. The histologic changes associated with adenitis were large foci of necrosis with regular crown of epithelioid cells, without giant cell. The presence of Herpes simplex virus 2 was confirmed by immunohistochemistry and culture. Occurrence, physiopathology, clinical and histological aspects of Herpes simplex lymphadenitis in patients with haematologic disorders, are discussed.

Aged↗
PubMed1988

[Pseudolymphomatous aspects of mesenteric lymphadenopathies in Whipple's disease. Value of x-ray computed tomography monitoring].

Lymphadenopathy is a very common finding during the course of Whipple's disease (W.D.). Abdominal (mesenteric and retroperitoneal) tumoral lymphnodes may mimick malignant neoplasm, specially a lymphoma. The authors report the case of a patient who had an abdominal computer-assisted tomography (C.T.) at the diagnosis and during an eleven month survey for W.D. General C.T. findings can help to differenciate mesenteric lymphadenopathy in W.D. from those found in malignant lymphomas: low density (10-20 Hounsfield Units) because of the high fatty charge of Whipple's lymphnodes, lymphadenopathy in the lower mediastinum, progressive but slow improvement with antibiotic therapy.

Adult↗
PubMed1987

[Esophageal localization revealing Hodgkin's disease].

The authors report the case of a 28 year old man with Stage III E Hodgkin's disease presenting with massive upper oesophageal involvement with cervical and mediastinal lymphadenopathy. The diagnosis was confirmed by lymph node and endoscopic biopsies (mixed cellularity). A complete remission was obtained by chemotherapy (ABVD) followed by extended radiotherapy. Then other cases have been previously reported. Upper oesophageal involvement with mediastinal lymphadenopathy often occurring in young patients raises the differential diagnosis of a carcinoma. The efficacy of chemotherapy of first intention is underlined.

Adult↗
PubMed1986

[Multiple extra-bone sites of Kahler's disease].

The authors report the case of an IgA secreting multiple myeloma which, after a rapid initial remission, relapsed with skin, thyroid, testis and lung metastases without bone recurrence. A review of the medical literature on this subject underlines the poorly differentiated microscopic appearance and the low secretion of paraprotein of these extraosseous plasmacytic tumours which have a poor prognosis due to their increased malignancy.

Humans↗
PubMedDate not supplied

Visceral leishmaniasis and HIV-1 co-infection in southern France.

Between 1986 and 1993 visceral leishmaniasis (VL) was diagnosed in 50 adult patients with human immunodeficiency virus type 1 (HIV-1) infection (8 females, 42 males: 31 intravenous drug users, 11 homosexual or bisexual men, 6 heterosexual individuals, 2 blood recipients) from 5 hospital centres in southern France. Diagnosis of VL was by demonstration of Leishmania and isolation of promastigotes by culture in Novy-McNeal-Nicolle medium. Leishmania isolates were identified by their isoenzyme profile in 28 patients. All the patients were immunocompromised when VL was diagnosed. Their median CD4 cell count was 25 x 10(6) (0-200). However, only 21 patients (42%) fulfilled the 1987 CDC criteria for the acquired immune deficiency syndrome before VL developed. Fever (84%), splenomegaly (56%), hepatomegaly (34%), and pancytopenia (62%) were the most common presenting features. Clinical signs were lacking in 10% of patients. Anti-leishmanial antibodies were detected by indirect immunofluorescence or enzyme-linked immunosorbent assay in 26/47 cases (55%). Combining these techniques with Western blotting (WB) gave a positivity rate of 95%. Amastigotes were demonstrated in bone marrow aspirates in 47 cases (94%). Unusual sites for parasites were found in 17 patients (34%), mainly in the digestive tract but also skin and lung. Viscerotropic L. infantum zymodeme MON-1 was characterized in 86% of cases. Dermotropic zymodemes MON-24, MON-29, MON-33, and a previously undescribed zymodeme MON-183, were isolated from 4 patients. The response rate to pentavalent antimony was 50% and to amphotericin B 100%, but clinical relapses were noted in both groups. In endemic areas, VL should be considered as a possible opportunistic infection in HIV-infected patients.(ABSTRACT TRUNCATED AT 250 WORDS)

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

[Bone localizations disclosing Hodgkin's disease. Apropos of 11 cases].

The authors report 11 cases of Hodgkin's disease in which the first sign was due to bone involvement. Such observations are rare and raise diagnosis delays (Means: 5, 6 months in this series). Modern medical imaging techniques (scintigraphy, CT scan, magnetic resonance imaging) are very useful to an earlier diagnosis which will be better confirmed by lymph node biopsy given the poor information yielded by osseous cytology and/or histology. The elective localisation in bones belonging to the axial skeleton seems to support the hypothesis of a contiguous osseous involvement from lymphoïd organs in contact with bones. Evolution with chemotherapy and radiotherapy is very similar to that observed in patients without bone involvement.

Adolescent↗
PubMedDate not supplied

[Immunologic thrombopenic purpura and HIV infection in heroin addicts].

The authors have studied the clinical aspects and mechanism of the thrombocytopenia observed in heroin addicts in the light of recently published data. This relatively frequent complication of intravenous drug addiction must be related to the immunological disturbances caused by carriage of the HIV virus. The evolutive characteristics of thrombocytopenia in such cases and the therapeutic implications of this association between thrombocytopenic purpura and acquired immunodeficiency are discussed.

Acquired Immunodeficiency Syndrome↗
PubMedDate not supplied

[Plasmacytoma of the head of the pancreas: a rare cause of cholestatic jaundice].

A case of plasmacytoma of the head of the pancreas in a 75-year-old woman, revealed by obstructive jaundice, is reported. The tumor, which compressed the main bile duct, appeared to be round on sonographic and endoscopic retrograde cholangiographic investigations. Sonographically guided needle biopsy was performed but led to the erroneous diagnosis of pancreatic adenocarcinoma. Choledochojejunostomy and gastrojejunostomy were then performed but the patient died 10 days after the operation. Pathological examination of the specimens obtained at autopsy showed that the pancreatic tumor (as well as an other osseous lesion) were plasmacytomas with cells containing G immunoglobulins of the lambda type. Despite the failure of needle biopsy to lead to correct diagnosis in this case, the potential value of this method remains unequivocal as reported previously. Indeed, when positive results are obtained by this method in visceral localizations of plasmacytoma, hazardous surgery may be avoided and radiation and/or chemotherapy may be chosen preferentially.

Aged↗
PubMedDate not supplied

[Portal hypertension in schistosomiasis (author's transl)].

Pathological and clinical features of the portal hypertension in schistosomiasis are reminded. The value of the para-clinical investigations (immunology, endoscopy, angiography and hemodynamic controls) is discussed. Medical treatment is limited to parasiticidal action but an attempt to prevent the formation of granulomas by use of antilymphocytic serum has been reported. The surgical intervention is aimed at suppressing the splenomegaly and decreasing the portal hypertension. The indications of the various techniques are discussed (splenectomy, spleno-renal anastosomis associated with splenectomy, vascular porto-caval anastomosis, omentopexy, triple arterial ligation).

Granuloma↗
PubMedDate not supplied

[Is drepanocitic trait asymptomatic? (author's transl)].

With regard to its distribution the drepanocytic trait has a slight pathological incidence and does not appreciably alter the vital prospect. It is not, still, completely asymptomatic and may be, in special pathophysiological conditions, a morbidity and even lethality risk factor. Its connexions with various other diseases should be considered.

Anemia, Sickle Cell↗