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Biomedical subjects

D Köhler

Publications and source records attributed to D Köhler.

At least 199 records · Page 11Linked to original sources
PubMed1983

[Diagnosis of intracardial and paracardial space-occupying masses: comparison between two-dimensional echocardiography and computed tomography].

The validity of two-dimensional echocardiography (2-D echo) and computed tomography (CT) in the detection of intra- and paracardial tumors and thrombi was compared in 32 patients: 7 endocardial myxomas, 1 left ventricular fibroma, 2 paracardial cysts, 1 paracardial tumor, and 21 thrombi. In 16 cases intraoperative findings served as a control. The 2-D echo is easier to handle and free of radiation of contrast media. CT can visualize cardiac tumors independently of their location, whereas 2-D echo sometimes insufficiently images paracardial and right ventricular structures. It must be considered an advantage that 2-D echo detects mobile tumors such as those attached to valves, which the CT will not show. The tissue involved is more likely to be characterized by CT, although results are unreliable. However, in all cases tumors could be differentiated from thrombi by means of additional diagnostic criteria, such as the pattern of wall motion or valve motion. 2-D echo and CT therefore appear to be complementary methods rather than competitive ones. Invasive diagnostic procedures are required only to answer particular questions, e.g., concerning the coronary arteries.

Cysts↗
PubMed1983

Effects of ketotifen on cholinergic induced airway obstruction.

By repeated inhalant carbachol provocation tests on 13 normal and 13 asthmatic subjects, we investigated the effect of ketotifen (as compared with placebo) on the cholinergic responsiveness of the airways. In normal subjects, ketotifen reduced the slope of the linear regression lines, calculated from the airway resistance vs. the intra-pulmonary deposited amount of carbachol (reactivity). By adding a single dose of 80 mg of propranolol the bronchial reactivity was increased. Neither placebo nor ketotifen pretreatment altered the response to propranolol. In asthmatic subjects, the reactivity of the airways to carbachol was reduced after 7 days of ketotifen treatment. Propranolol increased the pre-challenge airway resistance values, and ketotifen did not reduce this bronchoconstrictive action. We could not observe any influence of ketotifen on the potentiation of the carbachol-induced bronchoconstriction. We conclude that ketotifen on the potentiation of the carbachol-induced bronchoconstriction. We conclude that ketotifen reduces the bronchial reactivity as assessed by carbachol inhalation in normal and in asthmatic subjects.

Adolescent↗
PubMed1982

[Dynamic computer tomographic for tumours of the facial skeleton (author's transl)].

Serial computer tomography after intravenous bolus injection of contrast provides information concerning the vascularity of tumours in the facial skeleton. In addition the relationship of the tumour to the major vessels and their displacement or compression can be demonstrated. This provides information additional to the ordinary computer tomogram, so that neoplasms of the facial skeleton can be shown at various stages and their extent determined. A requirement for the use of serial CT is a scanner with a short scan time and scan interval.

Angiography↗
PubMed1980

[A new method for the measurement of regional lung ventilation].

The measurement of regional ventilation with radioactive gases (133Xe, 81Kr) is complicated and expensive. By means of a special device the authors have produced a 99mTc-aerosol with a particle size of less than 2.5 micrometer. If this aerosol is inhaled during a slow inspiratory vital capacity manoeuvre, the distribution of ventilation can also be estimated in patients with obstructive lung diseases. Comparative measurement of ventilation distribution with 133Xe and the 99mTc-aerosol in patients with severe airway obstruction demonstrates the reliability of the aerosol deposition pattern in assessing ventilated volume distribution in the lung 132 measurements in patients with clinical signs of lung emboli demonstrate the clinical applicability of the new device.

Aerosols↗
PubMed1980

[A new method of combined inhalation and perfusion scintigraphy for the diagnosis of pulmonary embolism (author's transl)].

The combined inhalation and perfusion scintigraphy as a specific identification method of thromboembolism of the lung was tried out in 132 patients. A fine aerosol with selected droplet size was produced in a newly developed atomiser device and inhaled by taking a few deep breaths. Perfusion scintigraphy, which was performed immediately after inhalation scintigraphy, was effected with the same radioisotope, 99mTechnetiun. The disadvantages of inhalation scintigraphy, which are inherent in the method itself, were reduced to such an extent that it was possible to distinguish clearly between primary and secondary disturbances of pulmonary perfusion even in obstructive diseases of the respiratory tract, provided perfusion was disturbed in sufficiently large areas, i.e. of segment or lobe size.

Aerosols↗
PubMed1980

Effect of theophylline on mucociliary clearance in man.

An aminophylline infusion of 6 mg/kg/body weight improves the mucociliary clearance rate in some normal subjects and infertile male. The theophylline response cannot be predicted from the blood serum level, the smoking habits, or the alcohol consumption of normal males and infertile males. The in vitro sperm-motility needs further investigation. 99mTc-tagged monodisperse erythrocytes inhaled during a slow inspiratory vital capacity with a diameter of 7.5 micrometer and a volume of 200 microliter are most suitable to get reproducable deposition patterns. The reproducability of the clearance measurements in the same subjects with this method is within the 5% range.

Cilia↗