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Biomedical subjects

D Kob

Publications and source records attributed to D Kob.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Dose-time optimization in fractionated radiotherapy].

On the basis of an evaluation of different isoeffect correlations for normal tissue reactions supported by a clinical study, a number of correlations for the dose-time optimization of irradiations with equal fractionation intervals are derived from a simple approach for the survival rate of irradiated tumor cells based on a linear quadratic dose-effect function for an exponential cell proliferation. This allows to determine optimum single doses for every given fractionation interval which, applied with the number of fractions tolerated by normal tissue, lead to a maximum reduction of tumor cells. The values of these optimum fractionation parameters depend from cell proliferation and radiosensitivity of the tumoral tissue and vary with respect to a normal tissue tolerance for early and late reactions. The results are described for several fractionation examples. It is shown that, within the tolerance limits of normal tissue, a greater tumor remission is achieved by hyper-fractionated irradiation than by a small number of high-dose irradiations.

Dose-Response Relationship, Radiation↗
PubMed1988

[Information concerning radiation-induced sarcomas. Report on 2 cases].

Two cases of radiation-induced sarcomas are presented. Osteosarcomas developed in the frontal bone after a latency period of 36 years following operation for brain tumor with post-operative irradiation (48 Gy) in one patient and in the region of the right sacro-iliac joint after ablation of testis for seminoma with post-operative irradiation (60 Gy) in another patient. In the literature, the risk of developing an irradiation-induced sarcoma is considered to be low (0.05-0.2%). Both cases, however, underline the necessity of an exact indication for irradiation to avoid such complications.

Adolescent↗
PubMed1988

[Decreasing urologic complications by the centralized therapy of cervix cancer].

Report about the urologic complications seen in connection with 212 radical hysterectomies performed abdominally according to Wertheim-Held in the time between. 1.4. 1980-15. 12. 1986 in patients suffering from cervical cancer. There were 2 injuries of the urinary bladder while the operation procedure (= 0.9%), no injuries or late fistulas of the ureter. Dilatations of the upper urinary tract in patients treated only operatively were to be stated in 5%, half of them disappeared spontaneously. In case of operation plus postoperative x-ray treatment the rate of upper urinary tract dilatation was higher (= 15%). The centralization of treatment in the therapy of cervical cancer is an important tool for diminishing the rate of urologic complications.

Cancer Care Facilities↗
PubMed1987

Results of systemic chemotherapy of advanced bladder carcinomas (phase II study).

At the time of operation advanced carcinomas of the urinary bladder often have developed subclinical metastases. In 20 patients with metastases, inoperable carcinoma of the bladder responded to chemotherapy with a combination of adriamycin and 5-FU. 55% of the patients experienced either a complete or incomplete remission, which lasted long in some cases. In the future, suitable combinations of chemotherapeutics could participate in improving the prognosis of advanced carcinoma of the urinary bladder.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

[Histologic changes in the normal bladder wall following fractionated irradiation--an animal experimental study].

The histopathologic alterations of the bladder wall were investigated in 180 rabbits irradiated with different fractionations and total focal doses. Animals sacrificed on week after the end of irradiation showed alterations of the urothelium (desquamation, increased polymorphism of nuclei vacuolizations) as well as oedematous and hyperemic reactions in submucosa and muscularis. These alterations became stronger when the single and total focal dose and the ret value were increased. Animals sacrificed three to six months after the end of irradiation showed dystrophic-sclerotic processes as well as vascular obliterations in the submucosa and muscularis. The alterations were only clearly visible in case of a total focal dose of at least 30 Gy. With regard to a minimization of histopathologic alterations of the bladder wall, a fractionation of 1.5 Gy per day has to be considered as favorable in radiotherapy of the carcinoma of the urinary bladder.

Animals↗
PubMed1985

[Clinical aspects and results of therapy of endometrial cancer at the Department of Medicine of the Friedrich Schiller University in Jena 1964-76. II: Results of primary radiotherapy].

In this paper results of irradiation only at 235 patients are reported and discussed, different treatment methods are applicated. The 5-year-survival rate of all cases amounted 35.7 per cent, the rate of complications 6.2 per cent. Measures of improvement of therapeutic results are investigated.

Adenocarcinoma↗
PubMed1985

[Results of percutaneous radiotherapy of bladder cancer using 1 and 2 series of irradiation].

In a randomized prospective clinical study, the authors investigate the results of percutaneous radiotherapy (telecobalt) with two rhythms of fractionation in patients with vesical carcinomas. A one-series irradiation with 1.5 Gy daily (except the weekends) up to a total dose of 60 Gy is compared to a two-series irradiation (in the first series 3 Gy three days per week up to 30 Gy, then irradiation-free interval of four weeks, in the second series 1.5 Gy daily up to a total focal dose of 60 Gy). The five-year survival rates are 52% after one-series irradiation and 39% after two-series irradiation. The surgical treatment consisted in a most radical resection of the vesical tumor by TUTUR, partial resection of the wall, of transvesical tumor resection.

Aged↗
PubMed1985

[Results of radiotherapeutic optimization within the scope of combined operative-radiologic therapy of urinary bladder cancer].

The results of a prospective randomized clinical study for the comparison of a uniserial irradiation with a biserial irradiation are demonstrated. The investigations were performed on altogether 191 patients. Patients after cystectomy and supravesical by-pass of the urine were excluded. The operative treatment consisted of TUTUR, transvesical tumour resection or partial resection of the urinary bladder. According to the life table method the uniserial irradiation a survival rate of 52% and for the biserial irradiation of 39% after 54 months was calculated.

Aged↗
PubMed1985

[Clinical aspects and results of therapy in endometrial cancer at the Department of Medicine of the Friedrich Schiller University in Jena 1964-76. I: Evaluation of primarily surgically treated endometrium cancer].

In this paper therapeutic results are reported obtained from 444 patients with endometrial cancer which were operated on. In 260 patients the primary operation was completed by a different radiation therapy. The 5-years-survival rates are 75,9% Surgical and radiological therapeutic measures are demonstrated with regard to their development and to side effects.

Adenocarcinoma↗