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Biomedical subjects

D Lohmann

Publications and source records attributed to D Lohmann.

At least 91 records · Page 5Linked to original sources
PubMed1978

Insulin secretion, carbohydrate tolerance, fat metabolism and body weight in maturity onset diabetics requiring various methods of therapy.

Maturity onset diabetes (MOD) is characterized by the fact that the response of insulin secretion to glucose loading is either completely missing or is reduced if compared with that of persons whose metabolism is intact. But insulin secretion can be provoked by other specific stimuli. However, the quantitative IRI response can provide no information as to which of the MO diabetics must be treated by dietetic measures only and which of them are liable to treatment with sulfonylurea. It was, therefore, investigated whether in 109 patients suffering from recently developed overt MOD a differentiation from a therapeutical point of view can be attained by joint evaluation of stimulated IRI secretion, of glucose tolerance, of the dynamics of free fatty acids, of the fasting values of triglycerides and cholesterol and of the body weight. The findings suggest that no better differentiation for the two methods of treatment of MOD stated above is possible by simultaneous evaluation of the parameters of fat metabolism, glucose level and IRI secretion than by IRI secretion and carbohydrate tolerance alone.

Adult↗
PubMed1977

[Effect of diabetes therapy on the lipid parameters in blood].

In diabetics with different therapy indications the effect of the treatment on the lipid parameters of blood was examined. We estimated the change of the triglycerides, the cholesterol, the free fatty acids and the glycerol depending on the duration of the therapy. We used a combined stimulation test (combination of 100 g glucose, 1.0 g tolbutamide and 1.0 g glucagon in temporary coupling) as method for characterization of the type of diabetes. At the beginning of the therapy the fat parameters mentioned did not differ in patients with exclusively dietetic treatment and in SuH-patients. After longer duration of the therapy in exclusively dietetically compensated patients the fasting glycerol values decreased, were, however, statistically not significant. There were also no essential changes of the triglycerides, the cholesterol and the values of the free fatty acids in the two forms of treatment. The improvement of the carbohydrate tolerance could not be explained with changes of the insulin secretion. The results plead for the fact that the improvement of the diabetic metabolism develops by an increase of the peripheral insulin effectivity. The behaviour of the lipid parameters is not sufficient for an explanation of the carbohydrate tolerance.

Diabetes Mellitus↗
PubMed1977

[Liver cirrhosis and diabetes mellitus].

Statistically there exists an increased coincidence between liver cirrhosis and diabetes mellitus. The higher frequency of cirrhosis in diabetics compared with the normal population is to be explained partly from the higher risk of hepatitis. In addition to this the diabetic suffers from disturbances which further the development of cirrhosis, such as fatty degeneration of the liver, abuse of alcohol, more frequent inflammatory diseases of the bile duct and others. When a diabetes mellitus exists in liver cirrhosis it is to be differed between a diabetes due to absolute or relative insulin deficit and disturbances of carbohydrate clearance which are associated with normal or increased insulin levels. The latter form can be denoted as so-called liver diabetes. Main cause of this carbohydrate intolerance is an insulin resistance, partly by deminution of the metabolically active liver parenchyma, partly by the diminished reactivity of the peripheral tissues. By prophylactic measures and differentiated therapy may be favourably influenced lesions of the liver in diabetes mellitus as well as disturbances of the carbohydrate metabolism.

Blood Glucose↗
PubMed1977

[Various disturbances in beta cell function in diabetes mellitus].

Various types of insulin secretion may be differentiated in diabetes mellitus. In juvenile diabetes, there can not be induced in general any stimulation of insulin secretion, whereas in maturity-onset type diabetes a significant increase of the serum level was found after stimulation with glucagon or tolbutamide. However, neither moderate glucose doses given orally nor very high glucose doses given intravenously were able to stimulate insulin secretion in some of these patients. These findings suggest a complete insufficiency of beta cell glucose receptors in this specific type of maturity-onset diabetes.

Diabetes Mellitus↗
PubMed1976

[Drug therapy of hyperthyroidism].

The possibilities of the treatment of hyperthyroidism are mentioned, in which cases the author especially deals with the medicamentous therapy, taking into consideration the different chemical groups (imidazol derivations, thiourazil derivations, perchlorates) and their therapeutic mechanisms. The indications and contraindications of this treatment and the possible side effects are compiled in form of a table. The in-vitro-parameters which are necessary for the observation of the course are estimated in their significance. The author deals with the problems of the additional treatment. Taking into consideration indications and contraindications as well as controls of the course of functional parameters the medicamentous therapy concerned is a treatment with a good prognosis. It is promising particularly in such cases, when suitable parameters are used for the solution of the question concerning the end of the therapy. For this purpose nowadays two tests are at our disposal: 1. modified Alexander's test (radioiodine-test and suppression test under thyreostatic therapy) and 2. TRH-test with radioimmunological determination of TSH. The treatment should be carried out in adequate endocrinological dispensaries, as there are certain risks in not optimal therapy.

Conjunctivitis↗
PubMed1975

[Secretion of insulin and disorders in fatty acid metabolism in diabetic patients with coronary heart diseases].

The behaviour of the blood glucose, the insulin secretion, the free fatty acids, of glycerol and of the triglycerides after glucose tolerance test was examined in 66 patients with condition after myocardial infarction. 16 of the 34 patients loaded with an oral glucose tolerance test and 25 of the 31 patients loaded with an intravenous glucose infusion test showed disturbances of the glucose tolerance. The insulin secretion was significantly different neither in normal nor disturbed or lying in the borderline region glucose tolerance. With increasing glycerol values a significant deterioration of the glucose tolerance developed. The triglyceride values in the plasma increased with increasing insulin secretion. The results seem to be important with regard to the pathogenetic relations between the carbohydrate and fat metabolism and might be fo importance also for a differentiated therapy.

Blood Glucose↗