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Biomedical subjects

D M Barber

Publications and source records attributed to D M Barber.

At least 19 recordsLinked to original sources
PubMed1994

Anabolic-androgenic steroids and aggression in castrated male rats.

The resident-intruder paradigm of aggression was utilized to evaluate the aggression-inducing properties of two anabolic-androgenic steroid (AAS) compounds, methyltestosterone and stanozolol, in castrated male rats. Three weekly tests were conducted. On test week three, castrated males treated with methyltestosterone displayed levels of aggression equivalent to the levels displayed by castrated males treated with testosterone propionate on most of the behavioral indices assessed. In contrast, treatment with stanozolol at the dose used in this study was completely ineffective in eliciting aggressive behavior. AAS effects on aggression were mirrored by their ability to stimulate seminal vesicle growth. There were no effects of AAS treatments on the levels of locomotor activity. These findings highlight the heterogeneity of AAS effects on the nervous system and behavior and indicate that the psychological effects reported by human AAS abusers may depend upon the distinct chemical structures of the abused steroids.

Aggression↗
PubMed1989

Antibiotic persistence and tolerance in the lactating goat following intramammary therapy.

Due to the impact of the dairy quota system, the commercial use of goats for the production of milk and associated products is attractive to farmers diversifying their dairy interest. Intensification of milking and the expansion of herds will inevitably increase the incidence of caprine mastitis. The pharmaceutical industry and the veterinary surgeon will be required to provide data and advice upon the performance of currently available bovine intramammary products when used in the goat. This study produced evidence that one available bovine intramammary product, when infused into the glands of milking goats, produced a withholding time approximately double that defined for the cow. Following a course of infusions after three successive milkings, milk was not available for human consumption or for the production of cheese and yoghurt until 112 hours after the final infusion. This situation is likely to be representative of that which will occur for other currently available bovine intramammaries when prescribed in the goat.

Amoxicillin↗
PubMed1986

Microbial flora of the eyes of cattle.

The bacteria and mycoplasma occurring in the eyes of normal healthy calves were monitored in three groups of animals from purchase at about one week old to slaughter at about 15 months old. Non-haemolytic Moraxella bovis, Branhamella catarrhalis and Mycoplasma bovoculi were all isolated regularly, though their seasonal occurrence varied. The significance of these findings with respect to infectious bovine keratoconjunctivitis is discussed.

Animals↗
PubMed1985

Disease in a dairy herd associated with the introduction and spread of bovine virus diarrhoea virus.

In January 1982 an outbreak of diarrhoea among adult dairy cows in a closed herd of approximately 200 milking animals was shown to be caused by the introduction of bovine virus diarrhoea virus (BVDV). Affected animals showed a significant reduction in milk yield. One animal died and four were culled. Eight cows aborted and one weak calf was born. Of 121 calves born that year, 26 died, mostly from pneumonia, but five aged from three weeks to five months had enteric lesions of mucosal disease. Subsequent investigations of the whole herd in 1983 and 1984 showed that virus spread among the adults was slow and that BVDV continued to make a major contribution to calf losses. Again the greatest cause of loss was suppurative or fibrinous pneumonia. Overall, BVDV was isolated from 36 animals. Isolation of virus from a wide range of tissues of individual animals confirmed that they were viraemic at death. Viruses from calves dying of pneumonia and from aborted fetuses were non-cytopathic in tissue culture. Isolates showing varying degrees of cytopathogenicity were obtained only from tissues of one calf with a congenital neurological defect and the seven animals with enteric lesions consistent with a diagnosis of mucosal disease. Blood from all 89 BVDV antibody-free animals older than three months was tested for the presence of BVDV. Altogether, 12 calves were identified as persistently viraemic and all were apparently healthy when bled. Only two matured normally, four grew poorly and six died.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1978

Serum immune globulin status of purchased calves: an unreliable guide to viability and performance.

The circulating immune globulin levels and weights of 40 bought-in calves were measured as the group was introduced into a commercial calf rearing enterprise. Records of growth rate and mortality were kept during the 11 to 12 weeks the group remained on the premises. This was repeated with five further batches. No relationship could be found between the recorded performance parameters of the calves and either the immune globulin content of their serum or their weight at purchase.

Animals↗