PubMed Health⌕ Search

Biomedical subjects

D M Worthen

Publications and source records attributed to D M Worthen.

At least 19 recordsLinked to original sources
PubMed1979

An evaluation of iridology.

Iridology is an analysis of health based on examination of the iris of the eye. One hundred forty-three patients had photographs taken of both eyes. Nine-five patients were free of kidney disease, defined as a creatinine level of less than 1.2 mg/dL (mean, 0.8 mg/dL), and 48 had kidney disease severe enough to raise the plasma creatinine level to 1.5 mg/dL or greater (mean, 6.5 mg/dL). Three ophthalmologists and three iridologists viewed the slides in a randomized sequence without knowledge of the number of patients in the two categories or any information about patient history. Iridology had no clinical or statistically significant ability to detect the presence of kidney disease. Iridology was neither selective nor specific, and the likelihood of correct detection was statistically no better than chance.

Adult↗
PubMed1979

Immobilization of viral antigens on filter paper for a [125I]staphylococcal protein A immunoassay: a rapid and sensitive technique for detection of herpes simplex virus antigens and antiviral antibodies.

A new technique is described for the rapid detection and quantitation of herpes simplex virus (HSV) antigens and antiviral antibodies. It involves immobilization of HSV antigens on filter paper discs and subsequent analysis by 125I-labeled staphylococcal protein A (SPA) radioimmunoassay. A specially designed 96-well filtration device is employed which serves both as an incubation chamber and as a filtration manifold. It is rapid, simple, sensitive and specific, and requires only small volumes of antiserum and few target cells. The results may be readily and objectively quantitated. This technique permits the simultaneous assay of a large number of specimens in less than 1 h. Its sensitivity is considerably greater than that of other currently used immunologic techniques, and it is amenable to automation. These characteristics suggest that this [125I]SPA immunofiltration technique may be applicable to the rapid diagnosis of viral infections.

Antibodies, Viral↗
PubMed1979

Argon laser trabeculotomy:long-term follow-up.

A five-year follow-up of argon laser trabeculectomy in a group of 28 male patients with bilateral patients with bilateral primary open-angle glaucoma showed an overall mean pressure drop of 10.3 mm Hg in treated eyes. Twenty percent of the treated eyes had a pressure less than 20 mm Hg up to two years after treatment. No specific laser parameters were associated with pressure lowering. The pressure drop appears more patient dependent than treatment dependent. A randomized clinical trial is suggested.

Adult↗
PubMed1978

Future impact of manpower needs on ophthalmology training programs.

Current projections for ophthalmology manpower needs in the year 2000 suggest that the number of new ophthalmologists trained should be frozen at 500 a year. Factors that would cause a need to train more ophthalmologists would be a shorter workweek or workyear, an increased length of time for each patient visit, universal comprehensive health insurance, an earlier age of retirement, and an increased incidence of eye disease. The factor that would most likely reduce the need for new ophthalmologists would be the transfer of primary eye care delivery to nonophthalmologists. Modulation of resident numbers should be based on peer-judged program quality, not on geography or government edict.

Forecasting↗
PubMed1977

Clinical evaluation of continuous-wear hydrophilic lenses.

Twenty patients who had previously not worn contact lenses were fitted with a thin, continuous-wear hydrophilic contact lens in the right eye for 12 weeks. Seventeen patients completed the study and tolerated the lenses well. Some patients developed changes in corneal thickness, corneal curvature, and refraction, and some changes in visual acuity were reversed when the lens was removed. Many developed lens opacities that did not interfere with vision. We encountered no infections or corneal neovascularization in this study.

Adult↗
PubMed1976

A continuous-wear hydrophilic lens. Prophylactic topical antibiotics.

Seventeen patients, who were fitted with a continuous-wear hydrophilic lens for 12 weeks, received topical neomycin sulfate-polymyxin B sulfate-gramicidin (Neosporin) eyedrops in one eye only at a frequency of 3.7 times per day. The continuous wear of a hydrophilic lens in and of itself did not after normal bacterial flora, and the use of the antibiotic drops did not alter normal conjunctival flora. In addition, the eyedrops were not more effective when used in conjunction with the hydrophilic lens and did not appear to produce resistant organisms during the 12-week study. In normal eyes, a continuously worn hydrophilic soft contact lens that is well tolerated does not adversely affect the bacterial flora and the addition of neomycin sulfate-polymixin B-gramicidin drops at a frequency of 3.7 times per day does not appear to be beneficial or necessary.

Anti-Bacterial Agents↗
PubMed1976

Corneal endothelial damage associated with phacoemulsification.

Twenty-one cats underwent standard Kelman phacoemulsification procedures in their right eyes. The left eyes of the same amimals underwent a planned extracapsular cataract extraction or irrigation and aspiration for 15 minutes using the Kelman phacoemulsification unit. The corneal endothelium was evaluated at various times postoperatively using a stain for endothelial cell viability and scanning electron microscopy. The results suggested that the irrigation procedure alone is deleterious to the cat endothelium as is the rubbing of nuclear material against the endothelial cells. These two procedures caused additonal damage when combined in a routine phacoemulsification procedure.

Animals↗
PubMed1976

X-linked congenital nystagmus: a problem in genetic counseling.

A pedigree with X-linked congenital nystagmus is presented. A mother wished information about prenatal sex determination. The large number of clinically affected female heterozygotes in the pedigree illustrates a potential problem in genetic counseling for this condition and possibly other X-linked disorders which affect the eye.

Child, Preschool↗
PubMed1976

A randomized technique of constant-pressure infusion.

A population study of measured inflow values of eyes of a group of adult male rhesus monkeys was done with a randomized technique of constant-pressure infusion. Each eye was presented with a sequence of 18 4-minute runs, consisting of three infusion runs for each of six pressures, in which the order of appearance of a given pressure had been randomized. A statistical analysis of the results indicates that only the independent variables of infusion pressure, type of anesthetic, and position in the sequence of the 18 infusion runs had a significant effect upon measured inflow.

Animals↗
PubMed1976

Centrioles and cilia in the mesothelial cells of the pericanalicular region.

An evaluation of 70 trabecular meshwork biopsies obtained at the time of therapeutic surgery in glaucomatous and cataractous eyes revealed that the mesothelial cells in the iridocorneal angle had a marked abundance of cilia and centrioles. The distribution of cells showing cilia and/or centrioles is positively correlated with the apparent aqueous humor outflow pathway. The morphology and arrangement of the cilia-centriole complexes in the angle are highly variable and show many forms not previously reported in a single tissue. There were no obvious correlations between organelle abundance and the identifiable factors affecting the patients involved in this study.

Biopsy↗