PubMed Health⌕ Search

Biomedical subjects

D Millican

Publications and source records attributed to D Millican.

4 recordsLinked to original sources
PubMed1986

Host-adaptive antigenic variation in Bunyaviruses.

Bunyamwera virus and snowshoe have virus (family Bunyaviridae) were passaged up to six times through mosquito cells in culture and the resultant viruses were compared to the input, mammalian cell-passed virus using monoclonal antibodies raised against the input virus. The mosquito cell-adapted virus population consisted of mutants which were better adapted to replication in the new host than was the input mammalian cell-passed virus and were differentially susceptible to neutralization by antibody.

Aedes↗
PubMed1982

Relationship between glycoproteins of the viral envelope of bunyaviruses and antibody-dependent plaque enhancement.

Hamster antisera against three parental bunyaviruses, Batai, Bunyamwera and Maguari viruses, and six recombinant viruses which carried the nucleocapsid protein of one parent and the glycoproteins of the other, have been tested for their interaction with each of the nine viruses under study by two assays, plaque reduction neutralization and antibody-dependent plaque enhancement. Neutralization was clearly related to the specificity of the parental glycoproteins rather than the nucleoprotein, but the antibody-dependent plaque enhancement assay showed greater cross-reactivity.

Animals↗