Host-adaptive antigenic variation in Bunyaviruses.

W S James; D Millican

doi:10.1099/0022-1317-67-12-2803

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Host-adaptive antigenic variation in Bunyaviruses.

W S James·D Millican

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Abstract

Bunyamwera virus and snowshoe have virus (family Bunyaviridae) were passaged up to six times through mosquito cells in culture and the resultant viruses were compared to the input, mammalian cell-passed virus using monoclonal antibodies raised against the input virus. The mosquito cell-adapted virus population consisted of mutants which were better adapted to replication in the new host than was the input mammalian cell-passed virus and were differentially susceptible to neutralization by antibody.

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Aedes Animals Antibodies, Monoclonal Antibodies, Viral Antigens, Viral Bunyamwera virus Bunyaviridae Cell Line Chlorocebus aethiops Epitopes Genes, Viral Mutation Neutralization Tests Viral Envelope Proteins Viral Plaque Assay Virus Replication Journal Article Research Support, Non-U.S. Gov't

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W S James, D Millican. 1986. Host-adaptive antigenic variation in Bunyaviruses.. https://doi.org/10.1099/0022-1317-67-12-2803

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