[Reactive and dystrophic vascular changes in glioblastoma multiforme].
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Biomedical subjects
Publications and source records attributed to D Mureşanu.
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The effects of the X-rays on the peripherial lymphoid organs (lymph nodes and spleen) in male adult wistar rats "chemically thyroidectomized" (methylthiouracil) have been studied. Spontaneous death of these animals 9 days after the irradiation was determined by the hypoplasia (aplasia) of the hematogenous bone marrow. The spleen and lymph node changes -- represented by the lymphoid tissue depletion and reticulofibrosis -- in the experimental animals were similar to those observed in animals sacrificed 6-8 months after irradiation. They differed from the latter by the absence of the macromolecular hyperstability of the reticular and collagenous fibers, which is proper to early ageing by X-rays.
The whole-body irradiation of adult Wistar rats with a single dose of 800 r X-rays intensifies the lymph node changes and the decrease of the colloidopexic capacity of hepatosplenic macrophages established by the "reverse" administration of sexual hormones. The modifications observed after estradiol administration to the male rat are more marked after a 6 months' interval than those caused in the same interval by testosterone in the female rat lymph nodes.
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Bilateral ovariectomy of Wistar rats has per se a stimulative effect on the myeloid tissue, determining a hypercellularity of this organ-tissue. On the other hand, under the conditions of a whole-body irradiation with a single dose of 800 r X-rays, bilateral ovariectomy manifests a protective effect on the myeloid tissue preventing the development of hypoplastic, respectively aplastic modifications.