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Biomedical subjects

D N Lazareva

Publications and source records attributed to D N Lazareva.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[The effect of drugs on free-radical oxidation].

Data available in the literature and the results of original investigations of the effect of drugs on the free-radical oxidation process are summarized. It is pointed out that the character of drug influence on the on the free-radical oxidation process must be taken into account in selecting drugs for the treatment of particular diseases.

Animals↗
PubMedDate not supplied

[Effect of methyluracil on the sensitivity of animals to cardiac glycosides and on the coronary blood flow].

Tests conducted with rabbits, cats and mice showed methyluracil to lower the sensitivity to strophanthin in rabbits with myocardial infarction and in intact mice and its intravenous introduction reducing the toxicity of Adonis L. in cats. Oral administration of methyluracil for one week did not prevent in critical tests a strophanthin-induced arrhythmia in intact rabbits and in those with myocardial infarction. Intravenous administration of methyluracil caused an increase of the coronary circulation rate.

Animals↗
PubMedDate not supplied

[Pharmacological properties of Adonis sibir and A. vernalis growing in Bashkiria].

Animal tests have evidenced that Adonis sibir, whose glucoside composition is close to that of Adonis vernalis, exerts cardiotonic, diuretic and sedative action. The activity of Adonis sibir, growing in Bashkiria, meets requirements of the State Pharmacopea X for Adonis vernalis. By comparison with the latter Adonis Sibir. displays more pronounced sedative properties, is less cumulative, is absorbed at a slower rate on its enteral introduction and produces a greater slowing down of the cardiac rhythm.

Alkaloids↗
PubMedDate not supplied

[New prospects of using milk thistle (Silybum marianum) preparations].

Well-known and newfound properties of milk thistle (Silybum marianum) preparations are considered (including hepatoprotector, immunostimulant, antiproliferative, antisclerotic, etc.) and the ways of their realization are analyzed. Good prospects of further development of the drugs based on this medicinal plant are emphasized and the possibilities of wider clinical use are discussed.

Animals↗
PubMedDate not supplied

[Antiinflammatory and antiulcer effect of oxymethyluracil].

Enteral administration of oxymethyluracil in non-inbred albino rats decreased the inflammatory reaction to histamine, serotonin, bradykinin, carrageenan and trypsin, (being similar to voltaren) and reduced granulomatous inflammation, but influenced the proliferation to a lower extent than did voltaren. In contrast to voltarcen, oxymethyluracil also exhibited gastroprotective antiulcer properties.

Animals↗
PubMedDate not supplied

[The effect of catecholaminergic agents on the efficacy of immunostimulants].

The influence of combinations of immunostimulants (prodigiosin, methyluracil, levamisole) and catecholaminergic agents (dopamine, haloperidol, noradrenaline, phentolamine, isoproterenol, propranolol) on the results of antibiotic therapy of acute generalized Proteus infection and primary immune response to ram erythrocytes was studied on outbred albino mice. It was established that the agents influencing dopaminergic, alpha- and beta-adrenergic receptors can in some cases change the efficiency of the studied immunostimulants. The direction and degree of their action depend on the administration schedule.

Adjuvants, Immunologic↗
PubMedDate not supplied

[The luteotropic and luteolytic properties of synthetic analogs of 11-deoxy-PGE1].

The luteotropic and luteolytic properties of synthetic analogues of 11-desoxy-PGE1 were studied. Compounds Nos. 1 and 2 depending on the dose exerted the opposite effect: in low doses--luteotropic, in high doses--luteolytic. Compounds Nos. 3, 4 and 5 in the whole range of doses exhibited only luteolytic properties. The ranges of doses of prostaglandin exerting the luteotropic effect depend on the structural modifications of prostaglandin molecule. The luteolytic effect of synthetic analogue No. 5 was suggested to be determined by its influence on the hypophysis through the change of contents of cyclic nucleotides and gonadotropic hormones. It was demonstrated that the luteolytic effect of compound No. 5 is realized through the central nervous system, in particular, through the hypophysis.

Alprostadil↗
PubMedDate not supplied

[Effect of 11-deoxyprostaglandins E on the reproductive system].

The pharmacological properties of 4 derivatives of 11-desoxy-prostaglandins E (uterotonic, luteolytic, hypotensive, anti-inflammatory, diarrhogenic ones and also acute toxicity) were studied. Compound I possessed the uterotonic activity which decreased with an alpha-chain elongation and a radical introduction into a benzene ring. Compounds I and II exhibited the luteotropic properties at low doses and the luteolytic ones at high doses. The compounds under study had the hypotensive activity due to the presence of a benzene ring in a W-chain.

Alprostadil↗
PubMedDate not supplied

[Effect of hydroxymethyluracil on the course of experimental pancreatitis in the rat].

Experiments were carried out on 150 male rats weighing 200-250 g and 42 white mice weighing 18-20 g by using two models of acute pancreatitis, two models of inflammation and studying osmotic resistance of erythrocytes. In experimental pancreatitis hydroxymethyluracil (50 mg/kg) decreased the blood lipase activity. The therapeutic effect of the agent is related to its anti-inflammatory and membrane-protecting properties.

Acute Disease↗
PubMedDate not supplied

[Immunomodulating therapy of adjuvant disease in rats].

During a comparative analysis of efficacy of prodigiosan and its combinations with cyclophosphamide (5 mg/kg), asathioprine (4 and 20 mg/kg) and delagil (25 mg/kg) it was shown that the most pronounced suppression of the adjuvant disease was observed in the group of animals given cyclophosphamide with prodigiosan. The suppression of arthritis with cyclophosphamide, prodigiosan and their combination was followed by a decrease of autosensibility parameters--hypersensitivity to collagen and the amount of immune rosette-forming cells in the regional lymph nodes.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Pharmacological activity of synthetic prostaglandin analogs].

The results of studies on the biological activity of seven synthetic analogues of prostaglandins are presented. All the analogues under study possess uterotonic, antiulcer and anti-inflammatory activity; all the compounds except S1 induce diarrhea. The synthetic analogues studied decrease transiently and slightly the arterial blood pressure.

Animals↗
PubMedDate not supplied

[Device for measuring paw edema in rats and mice].

An unsophisticated highly precise mercuric electron-mechanic oncometer is proposed. It is intended for measuring paw edema in small laboratory animals during screening of new antiphlogistics. The device consists of two communicating vessels. The change in the mercury level after paw immersion transforms to the electrical signal by the induction technique. The controller of the displacement consists of a float, a ferromagnetic rod and a coil with windings. The movement of the rod changes mutual induction of the windings, amplitude modulation of the carrier frequency of the generator and unbalance of the differential diode bridge. The magnitude of the unbalance is recorded with the aid of appropriate units.

Animals↗