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D Nikolić

Publications and source records attributed to D Nikolić.

At least 19 recordsLinked to original sources
PubMed2006

[Surgical methods for the treatment of breast phyllodes tumors--a report of 319 cases].

UNLABELLED: Breast phyllodes tumors (FT) belong the fibroapitelial group of breast tumors arising in terminal ductulo-lobular unit (TDLU). Their incidence do not exceed 1% of all breast tumors. Biologicaly they can be divided into benign, borderline and malignant group. Incomplete tumor excision can be the reason for local reccurence. Malignant form of FT metastazise hematogenous most often in the lung. There is no uniform surgical opinion about the treatment FT. METHODS: We analyzed histopathology features of 319 FT of the breast surgicaly removed on Departement of surgery Institut of oncology and radiology of Serbia between 1.1.1985.-31.12.1994. Retrospective study of surgical treatment 84 patients with FT of the breast (69 benign, 4 borderline and 11 malignant) and 5 year follow up after surgery we analysed. RESULTS: local reccurence after surgery was found in 17 (20,2 %) patients(14 benign , 2 borderline and 1 malignant FT), pulmonary metastases in 6 (7,1%) patients with malignant FT. DFI was 21,3 months for local reccurences and 25,1 months for pulmonary metastases. DFS for al forms of FT was 71 % (p =0,7104) in 5-year follow up. CONCLUSION: According to biological behavior we propose wide excision for benign and borderline forms and simple mastectomy for malignant FT, and voluminous benign and borderline forms. Axillary disection is not necessary because lymphatic spread of malignant FT is unfrequent.

Breast Neoplasms↗
PubMed2005

Detection and assessment of near-zero delays in neuronal spiking activity.

Cross-correlation histograms (CCHs) have been widely used to study the temporal relationship between pairwise recordings of neuronal signals. One interesting parameter of a CCH is the time position of the central peak which indicates delays between signals. In order to study the potential relevance of these delays which can be as small as 1 ms, it is necessary to measure them with high precision. We present a method for the estimation of the central peak's position that is based on fitting a cosine function to the CCH and show that the precision of this estimate can be tracked analytically. We validate the resulting formula by simulations and by the analysis of a sample dataset obtained from cat visual cortex. The results indicate that the time position of the center peak can be estimated with submillisecond precision. The formula allows one also to develop a test of statistical significance for differences between two sets of measurements.

Algorithms↗
PubMed2005

Asymmetry of Hbeta Stark profiles in T-tube hydrogen plasma.

The whole Balmer H(beta) line profiles are studied in detail experimentally in the T-tube discharge for the wide range of plasma parameters. Besides the common one, two additional parameters are introduced to characterize the asymmetry behavior of the experimental Stark profiles with the reference point chosen in the center of the line. The experimental data are analyzed and benchmarked versus the simple theoretical model based on the effects of microfield nonuniformity and electron impact shifts.

Journal Article↗
PubMed2003

Comment on "Atomic spectral line-free parameter deconvolution procedure".

Recently Milosavljević and Poparić [Phys. Rev. E 63, 036404 (2001)] proposed a method for the deconvolution of isolated asymmetric plasma broadened atomic (neutral) spectral lines. The authors claim that their method enables a complete plasma diagnostics by applying this deconvolution on a single experimental line profile. In the present Comment the proposed deconvolution procedure and its application are reexamined.

Comment↗
PubMed2003

[Initial diagnosis of intra-abdominal hemorrhage caused by isolated splenic injury in blunt abdominal trauma].

Diagnosis of intraabdominal bleeding caused by spleen injury must be performed in the shortest possible period of time, with little risk for the patient, and with high preciseness. By its simple performance, high preciseness and little risk for the patient, DPL imposes as the predominant method in initial diagnostic of intraabdominal bleeding. Control and monitoring of lavage may duly signalize degree of bleeding. Preciseness of this diagnostic in our series ranges up to 93.3%. DPL method is especially important in a combined neurotrauma. Ultrasonography is a sovereign method in diagnostic of bleeding source as well as in monitoring of bleeding that from the very beginning does not require urgent surgical intervention. Its importance is in monitoring both intrasplenic and subcapsulary hematomas. It is not appliable in disturbed and haemodynamically unstable patients. It is in particular important in children where a maximum conservative attitude with respect to operative treatment has been assumed. CT takes the leading place with respect to preciseness of bleeding area, and the combined thoracoabdominal trauma. Preciseness of CT in our series comes up to 96.6%, but can be applied only in haemodynamically stable patients. Same as US of abdomen so the CT of abdomen represents a prominent method in monitoring of both intrasplenic and subcapsular hematomas, which do not require urgent surgical intervention.

Abdominal Injuries↗
PubMed2002

A simple method for bremsstrahlung spectra reconstruction from transmission measurements.

A new method for evaluation of bremsstrahlung spectra from transmission measurements has been developed. In this method some very well known facts relating to thick target bremsstrahlung spectra are a priori included in the calculation procedure. Some characteristics of the method are preliminarily illustrated on a 6 MV therapy linear accelerator.

Algorithms↗
PubMed2000

Missile injuries of the knee joint.

The results of the treatment of missile injuries of 170 knees in 162 patients are analyzed. The injuries were caused by infantry weapon missiles in 52(32.1%) and by fragments of mine or explosive devices in 110(67.9%) patients. The most frequent were penetrating injuries of the joint with multifragment fractures which in 15.8% cases were associated with injuries of the neurovascular bundle. Stabilization of bone fragments was required in 111(65.3%) knees. Stabilization was done by external fixation in 42(37.8%) and by plaster of Paris in 69(62.2%) knees. Additional mini osteosynthesis was required in 13(30.9%) knees stabilized by external fixation and in 3(4.3%) knees stabilized by plaster of Paris. Amputations were performed in 13(7. 6%) injured knees. During the postoperative period local and general complications occurred in 27(16.6%) patients. The most frequent local complications were suppurative articular infections requiring repeated surgery. Soft tissue defect covering was necessary in 53(33. 1%) patients. The poor late results were present in missile fractures of the knee. The most frequent were degenerative changes with bone defects. The possible surgical solutions in such cases are arthrodesis or total endoprosthesis implantation.

Adolescent↗
PubMed1999

Primary surgical treatment of war injuries of major joints of the limbs.

We present the results of primary surgical treatment of war injuries of major joints in 339 patients, wounded in the territory of the former Yugoslavia in the period June 1991-October 1995. The total number of surgically treated joints was 358. The injuries were inflicted by the fragments of explosive devices in 176 (51.9%) patients and by bullets in 125 (36.9%) patients. A single wound was present in 160 (47.2%) and several wounds in 176 (51.9%) patients; 276 (77.1%) patients had injuries of articular bone. The most frequently injured joints were knee joint 167 (46.6%) and elbow joint 72 (20.1%). Associated neurovascular injuries were present in 68 (18.9%) patients. Postoperative bone fragment stabilization was required in 254 (70.9%) joints. Stabilization was by plaster of Paris in 148 (58.2%) and external fixation in 85 (33.4%) patients. Postoperative course was uneventful in 262 (77.3%) while postoperative complications occurred in 77 (22.7%) patients. Amputations were performed in 15 (4.4%) patients. After the primary surgical treatment 254 (74.9%) patients were discharged and directed to rehabilitation or home care and 81 (23.9%) patients required additional reconstructive surgery for bone and soft tissue defects.

Adult↗
PubMed1998

Subtrochanteric missile fractures of the femur.

The treatment results of subtrochanteric missile fractures of the femur in 41 casualties are analyzed. The wounds were inflicted by infantry weapon missiles in 29 (70.7%) and by fragments of mine or explosive devices in 12 (29.3%) casualties. The associated neurovascular bundle injuries were present in 11 (26.8%) patients. Fracture stabilization was done by external fixation in 25 (62.5%): group A; and by plaster of Paris in 15 (37.5%) patients: group B. The postoperative period was uneventful in 14 (35.0%) and early or late complications occurred in 26 (65.0%) patients. Bone infection developed in six (15.0%) and fractures did not heal in four (10.0%) patients. Complications were present in 13 (52.0%) patients from group A and in 13 (86.7%) patients from group B. Delayed fracture healing and fracture nonunion were present in group A and contractures of large joints in group B. Subtrochanteric missile fractures of the femur present very severe injuries where the treatment is followed by a very high percentage of complications. External fracture fixation in this region facilitates the care, stability, early covering of soft tissue defects and early physical therapy.

Adult↗
PubMed1996

Arthroscopy of the knee in war injuries.

The results of arthroscopic removal of bullets and explosive ordnance fragments from the knee joint are presented. The operations were performed on 18 patients injured in battle operations in the former Yugoslavian territory in the period September 1991-October 1994. The indications for arthroscopic operations were positive radiographic findings, a locked knee, pain, effusion, instability and painful movement. In 13 patients, bullets and explosive ordnance fragments were removed arthroscopically, while in five patients, the clinic findings were found to be misleading. There were no complications from the arthroscopic surgery.

Adult↗
PubMed1994

Effects of cis-diamminedichloroplatinum II (cisplatin) on the splenic tissue of rats: a histoquantitative study.

Histoquantitative methods were applied to study the changes of splenic structure and proportions of splenic tissue compartments in cisplatin-treated (6 mg/kg body wt) male Wistar rats. Six days after treatment the significant reduction of volume density of white pulp was observed, which was due to the very prominent decrease of volume density of follicles. The volume density of periarteriolar lymphatic sheaths did not change substantially. Volume density of the marginal zone was also significantly reduced. A significant increase of volume density of connective tissue was observed. Morphometrical parameters of the follicles were also markedly altered: the number of follicles per mm2 of spleen section area, the numerical density of the follicles in the spleen, and the total number of the follicles were significantly reduced.

Animals↗
PubMed1991

[The importance of hormone receptor determination in breast malignancies].

Estrogen and progesterone receptor phenotypes expressed as "positive" or "negative" are widely used for the determination of estrogen dependence of primary breast tumor. In our opinion the receptor phenotype, so important for biological and clinical behavior of tumor, should consider the quantitative values of receptor content. For this purpose, the correlation between quantitative estrogen versus progesterone receptor content and the distribution of the quantitative estrogen and progesterone receptor content within some parameters of tumor and tumor-host was analyzed. Our results show: There is the same range of correlation between estrogen versus progesterone receptor content in tubular tumor type, invasive ductal and lobular carcinomas, and in all three histologic grades; Histologic type influences the estrogen dependence through histologic grade. There is no difference in distribution of the quantitative estrogen and progesterone receptor content when corresponding grades of tubular tumor type, invasive ductal and lobular carcinomas are compared; In premenopause status histologic grade defines different groups with regard to the quantitative progesterone receptor content; In postmenopause status histologic grade defines different groups with regard to the quantitative estrogen and progesterone receptor content; In tumors with histologic grade I, transition of pre to postmenopause status is connected with a significant increase of the frequency of the high quantitative estrogen receptor content; In tumors with histologic grade III, transition of pre to postmenopause status is connected with a significant increase of the frequency of the low quantitative estrogen and progesterone receptor content.

Breast Neoplasms↗
PubMed1990

[The effect of hormones on tumor growth].

It is well documented that estrogen influences the growth of mammary carcinoma. Estrogen-induced response of target tissue includes protein-biosynthesis as well as stimulation of cell proliferation. Estrogen stimulates tumor cell proliferation in vitro in a dose-related manner by shortening the cell cycle time primarily at the G1 duration and by increasing the number of dividing cells per cycle. The mechanisms of estrogen action on target cell proliferation are not understood well and because of controversial experimental results the role of functional estrogen receptors in estrogen-induced proliferation is not yet clear. In this work, we studied the effect of estrogen on the growth of cells derived from primary tumors (N = 4) and malignant pleural effusions (N = 6) from patients with histopathologically verified breast cancer. We correlated steroid receptor content of malignant tissue used with results obtained for estrogen-induced cell proliferation. It was shown that there was a positive correlation between steroid receptor content and effect of estrogen on cell proliferation in most of the cases studied (7/10). Our study also confirms the possibility of positive and negative influences of estrogen on modulation of tumor cell growth.

Breast Neoplasms↗
PubMed1989

[Surgical treatment of uncontrolled hemorrhage in the retroperitoneum of the minor pelvis].

The purpose of our work is to point out some wellknown facts about the bleeding from presacral vessels, because of This bleeding may be very profuse and dangerous. It occurs as intraoperative complication in combined abdominoperineal resection of the rectum, as well as the avulse injuries of the retroperitoneal part of the rectum, which are usually combined with fractures of the sacral, coccigeal or other bones of the pelvis. We want to show here, that it is not recommended to spend a lot of time in trials to make haemostasis with the usual methods, it is better to pack the whole area with gauze, as the only way to control such bleedings.

Adolescent↗
PubMed1989

[High doses of Streptase in the treatment of deep venous thrombosis of the lower extremities].

We apply the high dosed Steptase in last 10 months, and we find that there are the following advantages compared with the conventional application of Streptase: in 81,20% of cases we had had good results; it reduces the frequency of the complications-bleeding occurred in only 6.20% of the treated patients; it simplifies the application and reduces the lasting of the hospitalisation; In 12 of our 13 patients the treatment was one or two days; in only one case the treatment was repeated the third day.

Female↗