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Biomedical subjects

D Nikolić

Publications and source records attributed to D Nikolić.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Myositis ossificans in recurrent synovial hemangioma of the knee].

A case of myositis ossificans in 15-year old boy that occurred as a complication of the recurrent synovia hemangioma of the left knee was presented. The alteration was diagnosed as: osteosarcoma, chondrosarcoma and chondromyxoid fibroma by the pathologists from other institutions. The diagnosis of myositis ossificans was established using numerous histochemical and immunochemical methods (PAS, PAS diastasis, Alcian blue, Masson trichrom, von Kossa, Azur A, Toluidin blue, Goldner, method by Peris, Citokeratin, S-100, NSE and Vimentin). The presence of zonal phenomenon, as the one observed in the presented case, is one of the most significant criteria for differentiation of myositis ossificans from osteosarcoma.

Adolescent↗
PubMedDate not supplied

[Development of highly specialized clinical drug trial units within health care institutions].

The purpose of the most of clinical trials conducted under the auspices of pharmaceutical industries is to evaluate the safety and efficacy of drugs, and they are conducted at university health care institutions or appropriate clinical centres. Close collaboration among the investigators, potential investigators and other academic citizens is essential for an effective and efficient conduct of these studies. Clinical studies usually test a drug which is to be instituted for the first time; therefore more attention is being dedicated to its administration, with monitoring of a greater number of valid parameters in accordance with the Good Clinical Practices (GCP) and Good Laboratory Practices (GLP) standards. These are very strict standards, which have been internationally adopted and are valid worldwide. They define the documentation required, the setting method, the necessary equipment and the facilities within which the clinical trials are to be conducted, as well as human resources indispensable for carrying out the clinical trials. The objective of this paper was to determine whether our medical instructions fulfil the necessary conditions for establishing the clinical trials units. Creation of a symbiosis of this kind (between the pharmaceutical industry and the appropriate health care institutions), reflected in the clinical trials unit, should enable the drug research and development to remain within our country.

Clinical Trials as Topic↗
PubMedDate not supplied

[Dislocation of the knee joint].

Dislocations are the rarest but the most severe injuries of the knee joint. Six patients with traumatic knee joint dislocation were treated at the Clinic for Traumatology and Orthopedics of the Military Medical Academy in the period January 1989-November 1998. Popliteal artery was injured in 3 patients. The injuries required reconstruction and the treatment in 1 patient ended with upper leg amputation. In one case the diagnosis was irreducible lateral dislocation. Surgical reparation--reconstruction of ligamentary apparatus was performed in 4 patients. Concerning the knee joint stability satisfactory results were achieved. Knee joint dislocations are very severe injuries requiring thorough diagnosis of the possible injury of neurovascular bundle and surgical treatment.

Adult↗