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D Pavlović

Publications and source records attributed to D Pavlović.

50 records · Page 3Linked to original sources
PubMedDate not supplied

Low catalase activity in rats with ureteral ligation: relation to lipid peroxidation.

Progression of some renal diseases is characterized by generation of reactive oxygen metabolites that are also involved in the pathophysiology of obstructive nephropathy. Catalase activity and lipid peroxidation were investigated in rats with unilaterally (UUL) and bilaterally ligated ureters (BUL). Forty-eight hours after ligation, the animals were sacrificed, and enzyme activity as well as the malondialdehyde (MDA) concentration were measured in the plasma, kidneys and livers. The activity of catalase was significantly reduced in the plasma of the BUL rats and in the kidneys of both investigated groups. In the liver, catalase activity was decreased only in the BUL group. The MDA concentration in the plasma and kidneys of the BUL rats was significantly increased while in the liver it remained unchanged. These results suggest that lipid peroxidation in the induced uremic state could be responsible for catalase inactivation.

Animals↗
PubMedDate not supplied

[Activity of delta-aminolevulinate dehydratase and glutathione levels in the erythrocytes of patients with endemic nephropathy and in healthymembers of their families].

In a previous paper a markedly decreased activity of delta-aminolevulinate dehydratase (ALA-D) in patients with endemic nephropathy and in 24.6% of their healthy family members, was found. In this study the possible mechanisms of the decreased enzyme activity and the level of erythrocyte glutathione in patients and in healthy members from nephropathic families, were studied. We established decreased ALA-D activity in endemic nephropathy patients and in some healthy persons from their families. The normal concentration of erythrocyte glutathione was found in all groups. However, it was possible to reactivate the ALA-D enzyme in vitro by addition of exogenous glutathione. The obtained results suggested a normal synthesis of ALA-D apoenzyme and the existence of some factors whose effect upon enzyme activity was mediated through a binding to the reactive groups in the active centre of his enzyme or by oxidation of he reactive groups. Therefore, increased concentrations of sulfhydryl compounds, mostly of reduced glutathione are necessary for an optimal ALA-D activity.

Balkan Nephropathy↗
PubMedDate not supplied

[Acalculia].

Acalculia is an acquired disturbance of calculation that has several clinical expressions. Disturbances cna be aphasic and nonaphasic. Further division is into alexia and agraphia for numbers, anarithmetria and spatial acalculia. In addition to these manifestations due to focal cerebral lesions also diffuse lesions can produce disturbance of calculia. Acalculia is also encountered as a developmental disturbance. Testing of acalculia has to encroach both oral and written calculations with clinical and standardized neuropsychological tests.

Aphasia↗