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D Pometta

Publications and source records attributed to D Pometta.

At least 73 records · Page 4Linked to original sources
PubMed1984

Liver glycerokinase deficiency in man with hyperglycerolaemia and hypertriglyceridaemia.

Hyperglycerolaemia and glyceroluria is described in a patient who presented transient dietary-induced hypertriglyceridaemia. The increased glycerol in blood and urine was related to glycerokinase deficiency as evidenced by a hepatic tissue glycerokinase activity of one tenth (4.8 X 10(-5) mmol g-1 min-1) of that of normoglycerolaemic subjects (5.9 X 10(-4) ). As triglycerides are routinely determined by an enzymatic method after hydrolysis to glycerol, the differential diagnosis between true hypertriglyceridaemia and hyperglycerolaemia may prove difficult. Persisting "hypertriglyceridaemia' despite adequate dietary and drug treatment should suggest the existence of undiagnosed hyperglycerolaemia .

Adult↗
PubMed1983

[HDL-cholesterol and family incidence of coronary disease in the Genevan population].

In a healthy population, comparison of the lipoprotein lipid profile between subjects who were aware of the existence of cardiovascular disease among their relatives with the subjects who were not showed that the men in the former group had lower HDL cholesterol (1.3 mmol/l p less than 0.05) than men without a familial history of CHD (1.41 mmol/l). The difference was not significant in women. The values were within the normal range and there was an overlap of individual HDL cholesterol levels between the groups. This observation did however demonstrate that familial history of CHD was associated with lower HDL cholesterol and that low HDL cholesterol could play a significant role in certain families at risk.

Cholesterol↗
PubMed1983

[Reversible acquired acanthocytosis and hemolytic anemia associated with hypobetalipoproteinemia in a chronic alcoholic].

A 38-year-old male chronic alcoholic developed spur-cell anemia during an episode of non-A, non-B hepatitis. Lipid evaluation showed a marked decrease in cholesterol (1.98 mmol/l), in triglycerides (0.41 mmol/l) and in phospholipids (1.38 mmol/l) in total serum as well as in VLDL and LDL. Serum apolipoprotein B was also low. Cholesterol (C) and phospholipid (PH) content of the erythrocytic membrane was increased, as was the intraerythrocytic C/PH ratio. Hemolysis ceased with correction of the hypobetalipoproteinemia. The relationship between acquired acanthocytosis and lipid disorders is discussed.

Acanthocytes↗
PubMed1983

Metabolic effects of dietary fiber from dehulled soybeans in humans.

The normal diet of six healthy volunteers was supplemented by 21 g of dietary fiber from two different soybean seed fiber preparations, either a nonpurified and never-dried soya pulp A (39% dietary fiber) or a purified soya fiber B (79%), for 3 wk each. Mean daily fecal wet weight was increased by 19 and 38% in the fiber periods A and B as compared to a 2-wk control period (p less than 0.05). Stool frequency and transit time remained unchanged. Fecal fiber increased by 52% only during period B. Fecal calcium, magnesium, and iron were increased (p less than 0.05), mainly after higher intakes during both fiber periods. Excretion of neutral steroids remained unchanged, but their concentration was lowered (p less than 0.05). A 21% increase of fecal bile acids by fiber A was specifically due to deoxycholic acid (+32%, p less than 0.01). Oral glucose tolerance was slightly improved after period B. Neither fiber changed serum triglycerides, but fiber B increased low-density lipoprotein-cholesterol by 19% (p less than 0.01) and low-density lipoprotein-phospholipids by 16% (p less than 0.05). The ratio high-density/low-density lipoprotein-cholesterol, however, did not change significantly. Thus, dietary fibers from soybean do not seem to contribute to the hypocholesterolemic effect of soya. The results of this study also demonstrate that two apparently similar dietary fibers, coming from a single source, can exert distinctly different metabolic effects.

Adult↗
PubMed1982

Lipid, lipoprotein and APO-A and APO-B lipoprotein distribution in Italian and Swiss schoolchildren. The Geneva survey.

Cholesterol and triglyceride lipid, lipoprotein as well as apolipoprotein A and B levels, are presented for Italian and Swiss schoolchildren of similar socio-economic origin, living in Geneva, and ranging in age from 8-9 and 14-15 years. This cross-sectional study revealed some differences associated with the ethnic origin of the participants. Furthermore subtle changes were related to age, associated with puberty and were sex-specific. Apolipoprotein A and B levels were found to be significantly related to age and less significantly to sex, whereas apolipoprotein A levels decrease with puberty, apolipoprotein B levels increase slightly. Of the 387 Italian and the 416 Swiss participants, 173 Italian and 193 Swiss children had a complete lipoprotein examination including apolipoprotein determination, whereas serum cholesterol and serum triglycerides were studied in the total group.

Adolescent↗
PubMed1981

[HDL and lipoproteins in the families of coronary patients].

Male first degree relatives of acute myocardial infarction patients differ from a control population by virtue of their low HDL cholesterol. The results are compared with those obtained previously in women and children who are first degree relatives of coronary patients. Low HDL cholesterol (Fig. 5) is a familial feature of first degree relatives of acute myocardial infarction patients. This observation is of considerable interest in view of the role of HDL cholesterol in the development of atherosclerosis.

Adult↗
PubMed1981

Relationship between plasma insulin levels and high density lipoprotein cholesterol levels in healthy men.

Insulin and high density lipoproteins are considered to play a role in the development of atherosclerosis. In order to study whether there was a relationship between endogenous plasma insulin response and high density lipoproteins, an acute intravenous glucose tolerance test (0.5 g glucose/kg body weight) was performed in 94 healthy men, aged 20-49 years. Cholesterol and triglyceride levels were measured in very low density lipoproteins, low density lipoproteins and high density lipoproteins isolated from fasting serum by preparative ultracentrifugation. The subjects were divided into quartiles according to their fasting and post-glucose load plasma insulin and high density lipoprotein cholesterol levels. The results obtained in the subjects of the upper quartiles were compared with the results obtained in the subjects of the lower quartiles. The mean glucose disappearance rates were within the normal range and did not differ between the upper and lower quartiles. Subjects with high fasting plasma insulin had lower high density lipoprotein cholesterol levels (1.11 +/- 0.34 mmol/l, p = 0.01) than men with low fasting plasma insulin (1.40 +/- 0.37 mmol/l). Higher mean post-glucose plasma insulin was associated with lower high density lipoprotein cholesterol levels (1.18 +/- 0.32 mmol/l, p less than 0.05) and increased high density lipoprotein triglyceride levels (0.14 +/- 0.07) mmol/l, p less than 0.01) when compared with the men with low post-glucose plasma insulin (1.40 +/- 0.36 mmol/l and 0.09 +/- 0.03 mmol/l respectively). These observations reflect the close relationship between endogenous insulin and lipoprotein metabolism.

Adult↗
PubMed1981

[High-density lipoproteins in children with coronary diseases].

Low HDL-cholesterol and increased LDL-cholesterol have been shown to be cardiovascular risk factors. Recently, HDL/serum cholesterol and HDL/ LDL-cholesterol ratios have been advocated as more reliable indices of cardiovascular risk factors. In a comparative study, lipoprotein-cholesterol and lipoproteins-triglycerides as well as the HDL/serum cholesterol and HDL/LDL-cholesterol ratios were determined in children of patients with coronary heart disease (CHD) and in healthy control children. Sons of CHD patients had significantly lower HDL-cholesterol and HDL/LDL-cholesterol ratios than controls. In daughters, the HDL-cholesterol and HDL/LDL ratio were also decreased reaching significance in HDL only in the 12 to 16 year age group. Under comparative environmental situations, the results suggest that low HDL-cholesterol in children of CHD patients could be genetically determined.

Adolescent↗
PubMed1980

[Effects of fenofibrate in four types of hyperlipoproteinaemia and on apoproteins A and B in type IIa HLP (author's transl)].

Fenofibrate in doses of 300 mg/day was administered for 3 consecutive months to 31 patients with type IIa, IIb, III or IV hyperlipoproteinaemia (HLP). Mean plasma cholesterol levels decreased by 22% in type IIa (n = 15), by 19% in type IIb (n = 10), by 51% in type III (n = 2) and by 5% in type IV (n = 4) HLP. Mean plasma triglyceride levels were reduced by 32, 38, 60 and 52% respectively in these four types of HLP. Apo-A, measured in 11 patients with type IIa, HLP increased by up to 28% after three months' treatment, whereas alphalipoprotein cholesterol only slightly rose by a mean 11%. Apo-B decreased by 14%. Fenofibrate was well tolerated. Only one patient developed a pruriginous rash at the end of the treatment period.

Apolipoproteins↗
PubMed1980

Decreased HDL cholesterol in prepubertal and pubertal children of CHD patients.

Prepubertal boys and pubertal girls and boys selected because of the occurrence of acute myocardial infarction in their father or mother were characterized by a low HDL cholesterol when compared to healthy controls. This observation extends our previous observations of low HDL cholesterol in adult relatives of CHD patients to the children of the same patients. The occurrence of an HDL abnormality in young children demonstrates that the low HDL cholesterol precedes the occurrence of cardiovascular disease. Low HDL cholesterol was associated with increased VLDL cholesterol in prepubertal children and pubertal boys without significant increase in VLDL triglycerides. Smoking and drinking habits, and physical activity which are environmental factors known to affect HDL did not differ between these children and the controls and cannot account for the observed differences. The results show that the low HDL cholesterol is detectable early in life in close relatives of CHD patients, persists throughout the lifespan and is possibly genetically determined.

Adolescent↗
PubMed1979

[Coronary atherosclerosis and serum lipoproteins].

VLDL triglycerides were increased both in obese patients and obese controls. In lean CHD patients the VLDL triglycerides were higher than in lean controls but lower than in obese CHD patients. CHD patients had lower HDL cholesterol than controls. The lowest HDL cholesterol was observed when VLDL triglycerides were high in both CHD patients and controls. However, the differences in HDL cholesterol between CHD patients and controls with low VLDL triglycerides were more marked. It appears that factors other than VLDL triglycerides may also contribute to the low HDL cholesterol observed in CHD patients. Serum cholesterol and triglycerides did not reflect the more subtle changes occurring in the lipoprotein lipids of CHD patients.

Adult↗
PubMed1979

HDL lipids in close relatives of coronary heart disease patients. Environmental and genetic influences.

Female first-degree relatives of CHD patients differed, after the age of forty, from the normal control population by their low HDL cholesterol. Between the ages of 20 and 40 years a slight but significant increase in HDL triglycerides was observed. Except for hormonal contraception which induces significant lowering of HDL cholesterol in the first degree relatives, the observed differences in HDL lipids did not seem related to environmental factors but rather to be genetically determined. In contrast, the low HDL cholesterol observed in the wives of the CHD patients appeared to be related to differences in alcohol intake.

Adult↗