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Biomedical subjects

D Pometta

Publications and source records attributed to D Pometta.

At least 91 records · Page 5Linked to original sources
PubMed1979

High density lipoprotein cholesterol in male relatives of patients with coronary heart disease.

To study factors that play a role in the familial occurrence of coronary heart disease, very low density lipoprotein (VLDL) triglycerides, low density lipoprotein (LDL) cholesterol and high density lipoprotein (HDL) cholesterol were measured after preparative ultracentrifugation in first degree male relatives of coronary patients and in control subjects. The HDL cholesterol concentration was significantly lower in relatives of 20--71 years old than in controls. No increase of serum and LDL cholesterol was found. A low level of HDL cholesterol was observed even in the younger relatives who are less likely to have cardiovascualr disease. In older relatives low HDL cholesterol was found in the presence or absence of clinical evidence of coronary artery disease. The HDL-cholesterol concentration was inversely related to the VLDL triglycerides both in relatives and controls, but the regression lines were different ((P less than 0.001) for the relative (y = --0.166x + 0.43) and for the controls (y = 0.191x + 0.49). A low HDL cholesterol level appears to be a marker of relatives of coronary patients.

Adult↗
PubMed1979

Treatment of hyperlipoproteinemia (HLP) type II A with a new phenoxy-isobuturic acid derivative, procetofen.

Eleven patients with hyperlipoproteinemia (HLP) type II A, were treated for 3 months with a new compound, a phenoxy-isobuturic acid derivative, procetofen, at a dosage of 100 mg t.i.d. Mean plasma cholesterol decreased after 3 months by 25% from a pretreatment value of 10.3 +/- 0.7 mmol/l (p less than 0.001). The reduction of plasma cholesterol was apparently due not only to a decrease in LDL, as expressed from a marked reduction (15%) of the major LDL apolipoprotein moiety, apolipoprotein B, but also presumably to a decrease in VLDL as reflected from a marked reduction (45%, p less than 0.05) in plasma triglycerides. Furthermore, a marked favourable increase (28%, p less than 0.001) in HDL major apolipoprotein moiety, apolipoprotein A, was observed. No disagreeable side-effects were recorded, except for a skin rash in one patient.

Adult↗
PubMed1978

[Influence of hormonal contraception on serum lipoproteins].

Cholesterol and triglyceride measurements in lipoproteins (VLDL, LDL, HDL) separated by preparative ultracentrifugation showed that women aged 20 to 29 using oral hormonal contraceptives had increased LDL triglycerides without significant changes in serum lipids. Among older women (aged 30 to 39), changes induced by hormonal contraception were more pronounced. Triglycerides were increased in VLDL and LDL, with a significant rise in serum triglycerides. The LDL cholesterol was elevated without significant changes in serum cholesterol. None of the women had overt hyperlipoproteinemia. Routine serum cholesterol and triglyceride measurements may not reveal the changes in cholesterol and triglyceride lipoprotein content which may play a role in the increased incidence of cardiovascular disease among women using the "pill".

Adult↗
PubMed1978

[Low HDL cholesterol in close relatives and patients with myocardial infarct].

Male patients aged 40 to 59 who had had acute myocardial infarction three months previously displayed a lower HDL cholesterol than the HDL cholesterol of an apparently healthy control group. The male first degree relatives of patients with acute myocardial infarction, like the patients with coronary disease, had a low HDL cholesterol which differed significantly from the HDL cholesterol of the control group. Low HDL cholesterol appears to be a better "marker" of patients with coronary disease and relatives of patients with acute myocardial infarction than serum cholesterol and triglycerides. The importance of low HDL' cholesterol could be related to the role of HDL in the cholesterol transport system from the peripheral tissues.

Adult↗
PubMed1978

[Serum lipoproteins in family members of myocardial infarct victims].

Men 40 to 59 years old, first degree relatives of patients with myocardial infarction had a lower HDL-cholesterol concentration than a control group. This is in analogy with the low concentration of HDL-cholesterol observed in the myocardial infarction patients themselves. LDL and VLDL in relatives were not elevated in comparison to the controls. The low HDL-cholesterol could be the expression of a familial defect in cholesterol transport.

Adult↗
PubMed1976

[Hyperlipemia and diabetes].

There are several causes for hyperlipemia in the diabetic: (a) an increase in hepatic synthesis of prebetalipoproteins, and (b) reduced elimination of prebetalipoproteins and chylomicrons from the bloodstream, due to diminished activity of lipoprotein lipase in insulin deficiency. The role of heredity has been put in doubt by the observation that diabetes and hypertriglyceridemia are not transmitted by the same genetic factor. The shortterm and longterm implications of diabetic hyperlipemia are discussed, together with the treatment.

Chylomicrons↗