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Biomedical subjects

D Prigent

Publications and source records attributed to D Prigent.

23 records · Page 2Linked to original sources
PubMedDate not supplied

[Evaluation of the efficacy of mannitol in the treatment of ciguatera in French Polynesia].

Up till now, in the French Polynesia and in New Caledonia, people showing ciguatera intoxication receive a standard treatment: calcium + vitamins B6 and C by intravenous way and in addition, some drugs arriving to cure some symptomatic manifestations. In 1988, an investigation carried out in Majuro, Marshall Islands concluded that intravenous mannitol is efficient in the treatment of serious intoxications with suspecting cerebral oedema. Since, such a treatment has been utilized with success in several endemic areas. Our therapeutic evaluation was arrived to determine whether mannitol's efficiency is higher than the standard treatment in the ciguatera intoxications of mean seriousness. This investigation was carried out on two randomized groups: The first one receiving mannitol (250 cc intravenous at 20% injected in 1 h) the second one receiving the standard treatment (intravenous perfusion glucose serum 250 cc with 1 g of vitamins C, 250 mg of vitamin B6 and 1 g of calcium gluconate injected in 1 h). Seriousness of clinical status was evaluated according to a scale of score from 0 to 50, based on the importance of the clinical manifestations paresthesia, aches, asthenia, cardiovascular and digestive signs. Only patients getting a score at least 20 were included in this investigation. Clinical status of each patient was evaluated before any treatment (initial score) at the end of perfusion and at the 24th hour. Efficiency of each treatment respectively was evaluated according to the differences between these three different scores. CHI 2 and U Mann's and Whitney's tests were utilized for the statistical analysis.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Psychological follow-up of 52 patients in an internal medicine service at the Territorial Hospital Center of Papeete (Tahiti)].

This prospective study of a duration of 7 months was made on 52 patients admitted in a International Medicine Service and watched over psychological aspect. The sample was composed mainly of Polynesians, two third of them being females. On the somatic aspect, the complaint more frequently recorded is a painful condition. Diagnosis of depressive status is made about almost half of the patients. The most obvious point is that Polynesian depressive patients are young and they expressed their profound discomfort not only by a suicidal attitude but also by a symptomatology in which body, body surface are the privileged significants.

Adult↗
PubMedDate not supplied

[Management of an isolated thyroid nodule or a heterogeneous nodular goiter, when thyroid scintigraphy is not available (Tahiti)].

Thyroidal nodes (non-cystic) always put forward some difficult decision. As a matter of fact, it would not be reasonable to undergo each time a surgical operation, but it would be catastrophic to abstain wrongly. When scintigraphy and mainly cyto-puncture are feasible, so a coherent decision can be taken. When they are not possible and when only ultrasonography is available, we propose that a decision be taken according to a comprehensive approach although each argument being individually disputable.

Biopsy↗
PubMedDate not supplied

[Parietal fibroplastic endocarditis].

Parietal fibroplastic endocarditis is commonly observed in two main diseases: Löffler' endocarditis and Davies' endomyocardial fibrosis. Endocarditis' damage is explained by the cytolytic effects of basic proteins present in eosinophil granules (major basic protein and cationic protein); long standing and amount of eosinophilic cells condition anatomic lesions. The clinical features are explained by the ventricular seat of endocarditis lesions (right, left, or both). They include in all cases: tricuspid and/or mitral insufficiency, adiastolic syndrome. Two-dimensional echocardiography has improved the diagnosis; ventricular angiocardiography remains the reference examination. Prognosis has been largely improved these recent past years by surgical endocardiectomy and valvular conservative surgery among children.

Endocarditis↗