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Biomedical subjects

D Spitzer

Publications and source records attributed to D Spitzer.

71 records · Page 4Linked to original sources
PubMed1982

The effect of intrinsic sympathomimetic activity of beta-adrenoceptor blockers on circadian heart rate.

1 The effect of a beta-adrenoceptor blocker without intrinsic sympathomimetic activity (propranolol) and a beta-adrenoceptor blocker with ISA (pindolol) on circadian heart rate was studied in 10 patients (3 women and 7 men) with an average age of 55 years and the following diagnoses: coronary heart disease (n = 7) and hypertension (n = 3). The therapy was carried out in a randomized, cross-over study, with 3 x 40 mg propranolol and 3 x 5 mg pindolol. 2 Propranolol lowered the averaged circadian heart rate significantly (P less than 0.001) from 78 to 68 beats/min. The rate decreased both during the day and at night and the reduction was greater the higher the control value. The minimal hourly heart rate also decreased significantly (P less than 0.005) from 65 to 69 beats/min. 3 After pindolol the averaged circadian heart rate was not markedly changed. It reached a stable rate of around 70 beats/min. At a heart rate of below 70 beats/min an increase in rate was observed, whereas above 70 beats/min a reduction was found. The mean heart rate during the day remained unchanged. There was a significant relationship between the level of the control heart rate and the decrease in rate (r = 0.85, P less than 0.005). 4 In a bicycle exercise test of 1 Watt/kg body weight over a period of 6 min, both beta-adrenoceptor blockers lowered blood pressure and heart rate to the same extent.

Adrenergic beta-Antagonists↗
PubMed1982

[Comparison of 24-hour long-term electrocardiogram and exercise testing in the detection of ventricular arrhythmias (author's transl)].

The incidence of ventricular arrhythmias was investigated in 100 patients with a mean age of 53 years with symptom-limited maximal bicycle exercise testing and 24-hour long-term electrocardiogram. 47% of the patients developed ventricular ectopic beats under exercise and 78% in the long-term electrocardiogram. Repetitive forms such as couplets and ventricular tachycardias were found to be three times as frequent with monitoring than with exercise. Therefore it may be concluded that 24-hour monitoring was superior to exercise testing in the detection of incidence and severity of ventricular ectopies. In contrast, there was no significant difference between the two method when comparing exercise testing with the first hour of monitoring. Therefore it may be concluded that exercise testing exposes the grades of ectopic activity occurring during the first hour of the monitoring session. Two-thirds of patients without arrhythmias under exercise had no or insignificant ventricular arrhythmias under monitoring, whereas two-thirds of patients with exercise-induced arrhythmias had advanced grade ventricular ectopic activity with monitoring.

Adult↗
PubMed1981

[Influence of physical training on resting and exercise haemodynamics in patients after acute myocardial infarction (author's transl)].

Resting and exercise haemodynamics were investigated in 17 patients with acute myocardial infarction after hospital treatment at the end of the third week. After 8 weeks of physical training measurements were repeated. The data were analyzed for the whole group and also with respect to enddiastolic pulmonary pressure (PAEDP) during exercise (50 Watts). Group I: (PAEDP less than 20 mm Hg) was regarded as normal. Group II: (PAEDP greater than 20 mm Hg) as pathological. Systolic and diastolic blood pressure during rest and exercise were not influenced by the training programme in the total group nor on subdivision into groups I and II. Resting heart frequency was reduced by 5 beats per minute in the total group after rehabilitation, but there was an increase of 10 beats per minute (p less than 0.05) on exercise in group I. Resting double product remained unchanged in all groups, but during exercise an increase from 15.8 +/- 3.4 to 18.1 +/- 4.1 (p less than 0.05) was noticed in group I. The reduction in double product during exercise in group II was insignificant. Under resting conditions PAEDP remained unchanged, but during exercise the mean PAEDP in the total group increased from 21.2 +/- 6.0 mm Hg to 24.3 +/- 6.0 mm Hg after rehabilitation. 15 out of 17 patients showed pathological values after rehabilitation. Increase in heart frequency and PAEDP may be interpreted as signs of heart failure during exercise. Therefore, an intensive exercise programme three weeks after acute myocardial infarction may be premature.

Adult↗
PubMed1981

[Electrocardiographic changes during long-term monitoring in a case of cardiac rupture after myocardial infarction (author's transl)].

Electrocardiographic changes in long-term electrocardiogram are described in a patient with inferior myocardial infarction and cardiac rupture. In a monitoring period of more than seven hours, malignant arrhythmias could be diagnosed, which are not specific for cardiac rupture. During the last minutes, sinus bradycardia, slow nodal rhythm, and idioventricular escape rhythm could be diagnosed.

Aged↗
PubMed1977

Luminescence quantum yields of sound and carious dental enamel.

The absorption and emission spectra of slabs of human and bovine dental enamel were determined. The absorption and scattering coefficients and emission quantum yields were computed according to theoretical models. The samples were gradually demineralized. The absorption, scattering, and emission parameters were determined as a function of the demineralization time. Using the theoretical models combined with the experimental values, ratio of the visible and UV luminescence, and the decrease of visible emission intensity upon demineralization are explained.

Absorption↗
PubMed1976

The total luminescence of bovine and human dental enamel.

The corrected emission and excitation spectra of human and bovine dental enamel and its separated organic material were determined at room temperature and liquid nitrogen temperature. In both materials three distinct luminescence peaks were found in the region 350-360 nm, 405-410 nm, 440-450 nm. The intensity ratios of the peaks of the enamel do not differ substantially upon removal of the inorganic component. Hence a conclusion is confirmed that the organic component is the most responsible material for the total luminescence of the enamel. Several hypothesis are available for determination of the nature of luminescence of the organic components. Differences in the excitation spectra are discussed. Phosphorescence emission and phosphorescence lifetimes were determined.

Animals↗
PubMed1975

The absorption and scattering of light in bovine and human dental enamel.

The reflectance and transmission of thin slabs of dental enamel has been measured at all wavelenghts between 220 and 700 nm by means of an integrating sphere. From the results the true scattering and absorption coefficients have been computed. The theoretical model used is an extended two-flux model, which is presented and discussed. The absorption spectrum of the dissolved organic component of enemel was also determined. An absorption peak at 270 nm is common to all the spectra. This peak in the bovine enamel spectrum is about three times as high as in the spectrum of human enamel. The peak of the dissolved material is about as high as the peak of the corresponding enamel. Hence it is concluded that the organic component, presumably aromatic amino acids, is responsible for most or all of the observed optical absorption.

Absorption↗
PubMedDate not supplied

[Acoustically evoked brain stem potentials in infants with velum clefts].

Brainstem acoustic evoked responses were recorded from 37 infants with cleft palate. Only 35% presented normal auditory thresholds. 27% had a bilateral 22% a unilateral hearing deficit of more than 30 dB. Controls after operative closure of the cleft showed no improvement of the conductive hearing loss.

Auditory Threshold↗
PubMedDate not supplied

Marginal medicine.

Explore the source record for details and available documents.

Delivery of Health Care↗
PubMedDate not supplied

[Effectiveness of local prostaglandin instillations in tubal pregnancy in relation to preoperative beta-HCG level].

33 patients with tubal pregnancy and beta-HCG level less than 2500 mIU/ml were treated with local, laparoscopic Prostaglandin-injection. Re-operation was not necessary and beta-HCG fell to undetectable levels in 73% (p = 0.05). Serial beta-HCG correlated poorly with outcome. In patients with an increasing beta-HCG success was limited to 55% (p = 0.59). In contrast patients with falling or stable beta-HCG values had success rates of 85.7% (p = 0.22) and 83.5% (p = 0.30) respectively. Our data suggests there may be a clinical advantage to the use of prostaglandin-injection for the conservative management of early ectopic pregnancy. However the utility of preoperative serial beta-HCG values in predicting success showed a trend, without reaching statistical significance.

Abortifacient Agents, Nonsteroidal↗
PubMedDate not supplied

[Risk of recurrence in HELLP syndrome].

The recurrence risk of HELLP-syndrome is reported to be between 2.6% and 24%. But yet, there are no accurate case reports about this topic available. In a retrospective study, 25 patients, which had suffered from a pre partum HELLP-syndrome, were interviewed about possible subsequent pregnancies. In 7 patients 8 pregnancies were found, which began between 5 and 55 months after the HELLP-syndrome. No recurrence of a HELLP-syndrome was observed in these 7 patients. Although in 71% a hypertension had been present during the HELLP-syndrome, only 1 patient had an elevated blood pressure in the subsequent pregnancy. Whilst all of the patients with HELLP-syndrome had been delivered by cesarean section, 50% of the patients were delivered vaginally in the subsequent pregnancy. There was no evidence of maternal or neonatal complications related to HELLP-syndrome. Nevertheless, even if the recurrence risk seems to be low, pregnancies after HELLP syndrome should be observed carefully.

Adult↗
PubMedDate not supplied

[Is there an intermittent HELLP syndrome?].

A case of an HELLP-syndrome in the 32nd week of gestation with complete remission of pathological biochemical data and clinical symptomatic within five days is reported. Twenty days later a Caesarean section because of severe fetal growth retardation was performed. Because of this case it has to be discussed, if an "intermittent" HELLP-syndrome does really exist?

Adult↗