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Biomedical subjects

D Tullio

Publications and source records attributed to D Tullio.

At least 19 recordsLinked to original sources

Occurrence of yeasts in cloacae of migratory birds.

Several species of yeast have been reported as pathogens in humans based on increases in immunodeficiency syndromes and as a result of immunosuppressant chemotherapy in cancer treatment. Domestic and wild birds are known to act as carriers of human pathogenic fungi. To gain additional information on the yeasts present in the cloacae of some species of migratory birds, 421 wild birds (24.39% out of 1726 birds caught in Romania, Hungary and Bulgaria) were sampled with the permission of the local judicial authority. The state of conservation of the birds (i.e. post-mortem alterations, colour of the mucosae etc.), along with their age and sex were determined. Samples were collected directly from the cloacae and cultured, and colonies were identified in each positive sample. Yeasts were isolated from 15.7% of the animals sampled, with the highest percentage found in coots (Fulica atra -58.8%) and the lowest in quails (Coturnix coturnix -1.7%). A total of 131 isolates belonging to 15 species of yeast were identified. Rhodotorula rubra was the yeast with the highest number of isolates (28.2%), followed by Cryptococcus albidus (18.4%), Candida albicans (9.2%), Trichosporon cutaneum (8.4%), Candida guilliermondii (6.1%), Candida tropicalis (6.1%) and other species. The present study represents the first survey on the occurrence of yeasts in the cloacae of migratory birds. The prevalence and species of yeasts isolated is discussed on the basis of the ecology, diet, and habitat of the birds.

Animals↗

[Heart failure in the elderly. Therapeutic strategies].

The different types of cardiac heart failures are examined: chronic failure deriving from systolic dysfunction, diastolic dysfunction failure, refractory heart failure, acute failure. Heart failure in the elderly is not always associated with impaired ventricular contractility with decreased EF and ventricular enlargement, but frequently with diastolic dysfunction of the left ventricle (LV). The echocardiographic examination is very useful to evaluate the type of ventricular dysfunction. Since the aortic baroceptor system is less sensible, diuretics and drugs decreasing after-load must be use carefully because of orthostatic hypotension and deterioration of kidney function. The elderly are most sensible to the action of digitalis because of the pharmacokinetic changes of the drug due to age. Although the current therapy of heart failure can relieve symptoms and prolong life, prognosis is always serious. The most effective therapy is prevention as it aims at the control and, if possible, at the regression of left ventricular dysfunction in the asymptomatic or slightly symptomatic stage.

Aged↗

[Ventricular arrhythmia in hypertrophic cardiomyopathy. When and how to treat].

Patients with apical hypertrophy have a natural favourable history. Non Specific Ventricular Tachycardia (NSVT) at ambulatory monitoring is more favourable if it is not associated with consciousness disorders. A high rate of NSVT episodes at Holter or the association with syncope can lead to a less favourable prognosis and therefore require pharmacological or electric treatment. The role of ET (electrophysiological test) has not yet been clearly described and is in progress. Recent studies of molecular genetics help to identify high-risk patients. Sustained monomorphic VT is not frequent but when it occurs it should be treated with BT. Patients with a light risk of VT should be treated with pharmacological therapy (white amiodarone and/or sotalol) and preferably with implantable defibrillator (ID) if VT cannot be eliminated. ID should be implanted also in the few patients surviving heart attack to avoid the risk of relapses.

Cardiomyopathy, Hypertrophic↗

[An allergic reaction due to i.v. urokinase administration].

We notify a case of anaphylactic reaction due to urokinase which was administered to a patient with extended anterior acute myocardial infarction. He showed some allergic reaction symptoms such as: cutaneas eritema and dyspnea with bronchial spasm which disappeared with an intravenous cortisone drug. Therefore we think that urokinase too might give rise to anaphylactic reaction.

Anaphylaxis↗

[The role of ergometric testing in the clinical evaluation of arrhythmia].

Ergometric stress testing seems useful in the identification of some supraventricular and ventricular arrhythmias induced by exercise, but poorly indicative for the purpose of prognosis, because the risk of sudden death seems to be linked to the extent of coronary artery disease or left ventricular failure. Ergometric stress testing, with ambulatory ECG, have an important role in the evaluation of the effects of antiarrhythmic drugs. This stress testing, favouring the importance of the efficacy of therapy, of probably worsening of arrhythmia, of congestive heart failure and/or conduction abnormalities, allows a more accurate prescription of physical activity and antiarrhythmic drugs.

Anti-Arrhythmia Agents↗

[Thrombolytic therapy in acute myocardial infarct].

The benefits, main pharmacological characteristics, indications, side effects and time limits for use of thrombolytic agents in acute myocardial infarction are reviewed. The authors also point out the strategies to follow in patients after thrombolytic therapy.

Age Factors↗

[Hazards of thrombolysis. A clinical case].

Thrombolytic therapy has led to a reduction in early and late mortality in myocardial infarction but it is not without its dangers. Two cases are reported in which it was adopted inadvisedly considering that later pathologies other than acute myocardial infarction were demonstrated. A less aggressive attitude is advised for emergency thrombolysis (pending the arrival of more effective, safer drugs) in the more peripheral centres where possible complications may be more difficult to handle.

Aged↗

[Idiopathic restrictive cardiomyopathy. Description of 4 cases].

The clinical and instrumental characteristics of four patients suffering from idiopathic restrictive cardiomyopathy are analysed. Patients were diagnosed following hemodynamic and histological tests. The major clinical symptom was cardiac decompensation and/or hyperkinetic or hypokinetic (3rd degree BAV) supraventricular arrhythmia (atrial fibrillation). Electrocardiographic and radiological alterations were not specific. The most typical echocardiographic symptom was the association of: biatrial dilation, dilation and hypertrophy of the right ventricle, normal left ventricular size, normal fractional shortening of the left ventricle. Septal hypertrophy was also observed in one case. Abundant pericardial effusion was present in all cases. When performed, echo-Doppler showed a relatively typical shortened deceleration time through the A-V valve. Catheterism revealed increased ventricular telediastolic pressures and a bi-plateau morphology of the ventricular pressure curve. Heart index was depressed in one patient and the ejection fraction was reduced in one case. Histological tests revealed interstitial fibrosis, cellular hypertrophy and, in one patient, myocardial amyloidosis. One patient underwent a heart transplant, two patients died while waiting for a transplant, one patient is still alive 13 years after the start of 3rd class symptoms.

Adult↗

[Electro-vectorcardiographic diagnosis of left ventricular hypertrophy in the presence of anterior fascicular block].

The aim of this study is to value the utility of the electro-vectorcardiographic criteria of left ventricular hypertrophy (LVH) in presence of the anterior fascicular block (LAFB) utilizing as "gold-standard" the left ventricular mass (LVM) determined by bidimensional echocardiogram (Eco2D). Fifty-four patients with LAFB type IV (S3 greater than 1.5 mV) (age: 58 +/- 10 years) have been studied. Thirty normal subjects have been studied as case control. MVS has been estimated by the method of Reichek. Through estimated parameters, the association of two criteria RI + SIII greater than 2.5 mV and AQRS greater than--45 degrees has shown a high sensitiveness, but a low specificity; so the association of this two criteria is'not sufficient to identify the LVH. In the presence of LAFB the voltages increase in the frontal plane is a constant finding while in the precordial leads is a less constant repeat as LVH manifestation. As a matter of fact the QRS loop tend to be pushed more towards the high and posteriorly. The delay of intrinsic deflections can be observed only in the strict hypertrophy with a without LAFB. The repolarization anomalies with the LAFB presence are more frequent. The electric signs specificity is different. She is good for all except for the repolarization alterations, especially if limited to the T-wave. So in the LAFB type IV of ten increase the QRS voltage in the frontal plane and we can see therefore Lewis' index increased without necessary subtending a LVH.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

[Arterial hypertension in pregnancy. Concise review].

The diagnostic principles and current therapy employed in cases of arterial hypertension during pregnancy are summarised. Apresoline is recommended in all forms of hypertension. Salt free diets and diuretics are usually not recommended in pre-eclampsia-eclampsia. In all other hypertensive forms they are, but in association with apresoline and/or beta-blocking agents.

Cesarean Section↗

[Electrocardiographic changes in acute abdomen].

We have examined the electrocardiograms of 516 patients hospitalized for acute abdomen. We have excluded from this research the younger patients than 14 years, those with shock, those with clinical signs of cardiopathy, those with electrolytic alterations and those executing anti-arythmic or anti-depressing therapy. We have found changes of repolarization and of rhythm. The changes of regularization consisted in flottening-inversion of T wave in the precordial and/or limb leads associated sometimes at negative deflection of the ST tract in the same leads. The changes of rhythm consisted in atrial or ventricular extrasystoles, paroxismal atrial tachycardia, paroxysmal atrial fibrillation. Sometimes the changes of repolarization and rhythm were associated. We have discussed the possible pathogenetic mechanisms answerable for these changes; sympathetic adrenergic activation mediate or no from a parasympathetic reflex, reduction of intra-cellular potassium, activation of enzymatic systems, reabsorption of toxic substaces. The Authors have underlined the benignity of these ECG changes, disappearing after resolution of abdominal disease, and the necessity of a correct interpretation of those, to avoid the arising of a iatrogenic disease.

Abdomen, Acute↗