Biomedical subjects

D V Rakov

Publications and source records attributed to D V Rakov.

3 recordsLinked to original sources

PubMed1998

Mathematical model for the blood coagulation prothrombin time test.

A mathematical model for the prothrombin time test is proposed. The time course of clotting factor activation during coagulation was calculated, and the sensitivity of the test to a decrease in the concentrations of coagulation proteins or their activities was studied. The model predicts that only severe coagulation disorders connected with a more than five-fold decrease in the concentrations or activities of the blood coagulation factors can be revealed by the test.

Blood Coagulation Factors↗

PubMedDate not supplied

[Cytogenetic changes in cells of mammals after irradiation by protons with an energy of 1000 MeV and gamma-rays 137CS].

The purpose was to investigate cytological and cytogenetic disorders in cornea epithelium and bone marrow cells of mice after different periods since irradiation by protons at an energy of 1000 MeV and gamma doses of 25 to 400 cGy (137Cs). Suppression of the mitotic activity of cells by ionizing radiations was a function of dose value. In addition, the rate of aberrant mitoses was dependent on the type of radiation and time elapsed after exposure. Coeffcients of the relative biological effectiveness of protons with an energy of 1000 MeV in 24, 72 and 120 hrs. after irradiation were calculated based on comparison of doses compromising mitosis in 50% of differentiating cells. For the cornea epithelium cell the coefficients amounted to 1.3; 1.2 and 1.1, respectively; for the bone marrow cells they were 1.2; 1.1 and 0.9, respectively. The fingerprint of the proton biological effect is a higher production of exchange aberrations suggesting more severe damages to the hereditary cells.

Animals↗

PubMedDate not supplied

[The influence of the water with decreased content of heavy stable hydrogen and oxygen (18O) isotope on development of radiation injuries at gamma-radiation in low dose].

The investigations of the water with decreased content of heavy stable hydrogen and of oxygen (18O) isotope received by the method of rectification were conducted on development of radiation injuries in organisms of the experimental animals. The objects of the investigation were male mice of Balb/c line. The animals were irradiated at the unit PX-gamma-30 with the gamma-radiation source 60Co in the dose of 25 sGy. It was observed that the water with decreased content of heavy stable hydrogen and of oxygen (18O) isotope influences positively the processes of restoration. It was manifested in decrease of the degree of gravity of radiation injuries in immune system organs (thymus and spleen), peripheral blood and marrow cells.

Animals↗