Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes: Binding of UACCA-Leu to 50 S subunits.
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Journal Article↗
Biomedical subjects
D Vazquez
Publications and source records attributed to D Vazquez.
Inhibition by siomycin and thiostrepton of both aminoacyl-tRNA and factor G binding to ribosomes.
Siomycin, a peptide antibiotic that interacts with the 50S ribosomal subunit and inhibits binding of factor G, is shown also to inhibit binding of aminoacyl-tRNA; however, it does not impair binding of fMet-tRNA and completion of the initiation complex. Moreover, unlike other inhibitors of aminoacyl-tRNA binding (tetracycline, sparsomycin, and streptogramin A), siomycin completely abolishes the GTPase activity associated with the binding of aminoacyl-tRNA catalyzed by factor T(u). A single-site interaction of siomycin appears to be responsible for its effect on both the binding of the aminoacyl-tRNA-T(u)-GTP complex and that of factor G.
Anti-Bacterial Agents↗
The effects of the rifamycin antibiotics on algae.
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Journal Article↗
Interaction of Ac-Phe-tRNA with e. coli ribosomal subunits. 1. Sparsomycin-induced formation of a complex containing 50 S and 30 S subunits but not mRNA.
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Journal Article↗
Interaction of Ac-Phe-tRNA with E. coli ribosomal subunits. 2. Resistance of the sparsomycin-induced complex to hydroxylamine action.
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Journal Article↗
Catalysis of peptidyl transfer by human tonsil ribosomes and effects of some antibiotics.
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Journal Article↗
Substrate and antibiotic binding sites at the peptidyl transferase centre of E. coli ribosomes.
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Journal Article↗
Action of sparsomycin on ribosome-catalysed peptidyl transfer.
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Anti-Bacterial Agents↗
The peptidyl transferase activity of ribosomes.
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1-Propanol↗
The function of 80 S ribosomal subunits and effects of some antibiotics.
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Anti-Bacterial Agents↗
[Peptidyl transfer to human ribosomes and their subunits from spleen, tonsils and tumors].
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Humans↗
Comparative studies on cytoplasmic ribosomes from algae.
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Biological Evolution↗
Antibiotics affecting the peptidyltransferase activity of ribosomes.
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Anti-Bacterial Agents↗
Ribosome-catalysed peptidyl transfer: effects of some inhibitors of protein synthesis.
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Anti-Bacterial Agents↗
Effects of some inhibitors of protein synthesis on the binding of aminoacyl tRNA to ribosomal subunits.
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Anti-Bacterial Agents↗
Binding to ribosomes and inhibitory effect on protein synthesis of the spiramycin antibiotics.
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Bacillus megaterium↗
Inhibitors of protein synthesis at the ribosome level. Studies on their site of action.
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Anti-Bacterial Agents↗
Binding of chloramphenicol to ribosomes. The effect of a number of antibiotics.
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Anti-Bacterial Agents↗