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Biomedical subjects

D Vujić

Publications and source records attributed to D Vujić.

18 recordsLinked to original sources
PubMed2002

Isotropic versus anisotropic modeling of photorefractive solitons.

The question of the isotropic versus anisotropic modeling of incoherent spatial screening solitons in photorefractive crystals is addressed by a careful theoretical and numerical analysis. Isotropic, or local, models allow for an extended spiraling of two interacting scalar solitons, and for a prolonged propagation of vortex vector solitons, whereas anisotropic, nonlocal, models prevent such phenomena. In the context of Kukhtarev's material equations, the difference in behavior is traced to the continuity equation for the current density. We further show that neither an indefinite spiraling of two solitons nor stable propagation of vortex vector solitons is generally possible in both isotropic and anisotropic models. Such systems do not conserve angular momentum, even in the case of an isotropic change in the index of refraction.

Journal Article↗
PubMed2000

Non-Hodgkin's lymphoma of the uterus and CNS.

We report a case of a non-Hodgkin's lymphoma of the uterus and central nervous system in an 8-year-old female. The neurologic signs included blurred vision, neck stiffness, and walking difficulties but no abdominal problems. She deteriorated further, and repeated lumbar punctures revealed the presence of malignant cells in the cerebrospinal fluid. A repeated ultrasound scan of the abdomen demonstrated a markedly enlarged uterus. Biopsy revealed B-cell non-Hodgkin's lymphoma. Treatment according to the Berlin-Frankfurt-Münster protocol was initiated, but she developed hyperventilation syndrome and required mechanical ventilation. Her condition improved after 1 week but then deteriorated again, and despite additional chemotherapy she developed myelosuppression and septicemia with multiresistant Klebsiella pneumoniae and eventually died 13 months after her first admission to the hospital. No clinical or laboratory signs of relapse were evident at the time of death.

Biopsy↗
PubMed1999

Microprocessor-controlled freezing device for cryopreservation of cell samples.

A freezing device for cryopreservation of blood mononuclear cells has been developed. The device is microcontroller operated, allowing cell freezing by a fully automatic, unattended process. To ensure optimum preservation, the temperature in the cell suspension uniformly decreases from room temperature to -100 degrees C and then the samples are transferred to long-term storage. The performance of the device has been tested using both physiological solution and a sample of cell suspension. The control of temperature variation of cell suspension in the entire temperature range has been realised with an accuracy better than +/- 0.1%. The viability of cells recovered from the frozen samples was 95%. The nitrogen consumption for one cycle of cryopreservation was 1.51. In addition to the fully automatic mode, the manual and semi-automatic modes are available for research purposes. The device has been designed using low cost and widely used electronic components and materials, it is compact and simple to operate.

Algorithms↗
PubMed1992

Bromocriptine (Bromergon, Lek) in the management of premenstrual syndrome.

The efficacy of bromocriptine (Bromergon, Lek) was studied in a group of 21 women with premenstrual syndrome (PMS). To qualify for inclusion, the patients had to have a score of 20 or more on Casper's Analog Self-Rating Scale for Premenstrual Tension Syndrome completed during the last premenstrual week. The study was designed as a double-blind, randomized, cross-over trial introduced by a wash-out cycle. Patients received Bromergon in a daily dose of 5 mg from cycle day 10 to the onset of menstruation for two consecutive menstrual cycles, followed by two placebo cycles or vice versa. The subjects were instructed to complete the scale every three days from cycle day 3 to the onset of menstruation. A statistically significant improvement due to the administration of Bromergon was observed in symptoms associated with overreactiveness to normal prolactin levels, i.e. abdominal tension, edema, weight gain and breast tenderness. Scores on the linear analog scale and physician's assessments differed regarding psychological symptoms. The investigators observed no difference in the presence of psychic symptoms in the treatment-free period, on Bromergon therapy and during the administration of placebo. On the other hand, self-rating scores reflected an improvement in the presence of depression and irritability during Bromergon treatment. The results obtained suggest that Bromergon may be a useful agent for the treatment of somatic symptoms associated with PMS, while it seems somewhat less effective in PMS cases where psychic symptoms are the major complaint.

Adult↗
PubMed1990

Amino acid supplemented diet vs. selective low protein diet in chronic renal failure.

Two groups of patients with chronic renal failure (creatinine clearance 13 ml/min) were treated with two different low protein diets: unselected protein diet with 0.35 g of protein/kg/day supplemented with amino acids (first group; 10 patients) and selective protein restricted diet with 0.6 g/kg/day of high biologically valuable proteins (second group; 9 patients). Both diets showed a good patient compliance. The serum urea level decreased significantly only in the first group of patients with a simultaneous disappearance of uremic gastrointestinal side effects. Progression of renal failure, shown by plotting the reciprocal of the serum creatinine concentration against the time, was significantly slower in the first group of patients and therefore their survival without dialysis was longer than that in the second group. The nutritional state was well maintained in both groups. Comparison of two low protein diets showed that the unselected protein diet supplemented with amino acids is more effective in delaying the progression of renal failure. The clinical state of patients is improved and their protein nutrition maintained.

Aged↗
PubMed1986

Effect of dihydroergosine (DHESN) on the serotoninergic system and behaviour: is DHESN a new antidepressive agent?

Acute (50.0 mg/kg) and repeated (0.1-10.0 mg/kg) administration of dihydroergosine (DHESN) to rats over 5 days lowered the concentration of 5-HIAA in the brain. DHESN given acutely increased the brain 5-HT in p-CPA-treated animals and diminished the probenecid-induced increase in brain 5-HIAA. In pargyline-treated rats DHESN enhanced the 5-HT/5-HIAA ratio. DHESN administered to rats repeatedly over 5 days decreased the level of 5-HT in blood platelets, and in vitro at concentrations of 10(-4) M and 10(-3) M inhibited the uptake of [14C]-5-HT in platelets. DHESN (10.0-100.0 mg/kg) potentiated the 5-HT syndrome produced in rats by pargyline and 5-HTP. This potentiation was blocked with cyproheptadine but not with haloperidol. DHESN (1.0 and 10.0 mg/kg) lowered the locomotor activity of rats and 10.0 mg/kg DHESN also reduced the duration of immobility in rats forced to swim in a restricted space. The results indicate that DHESN, like antidepressants, decreases the turnover of serotonin in the brain and potentiates the 5-HT-mediated behaviour. This might suggest that the drug should be further investigated for its potential antidepressive properties.

Animals↗
PubMed1986

Involution of bursa of fabricius in male and female chickens: a light microscopic histoquantitative study.

A histoquantitative study of the bursa of Fabricius in 3- and 6-month-old male Prelux Bro chickens (domestic selection) was made. All compartments of normal bursal tissue were examined. At 3 months of age, there were no significant differences in bursal weight and structure between males and females. The only difference observed was the higher volume density of follicular cortex and the lower proportion of follicular medulla in males compared to females. In 6-month-old male and female chickens, a different degree of bursal involution was observed. In the bursa of males, an advanced stage of involution was observed, whereas only the initial signs of bursal involution were found in females.

Animals↗
PubMedDate not supplied

[Acute pancreatitis in a patient treated with hemodialysis].

Acute pancreatitis presents about 1% of all acute abdominal diseases. Its mortality is about 20-50%. The main etiological causes are diseases of the biliary tract and alcoholism. In 10-20% of cases the cause is still unknown. Chronic renal failure is also mentioned as a possible cause of acute pancreatitis. The purpose of this article was to show the frequency and course of acute pancreatitis in patients on haemodialysis during the last 15 years with a case report. From 1976, to 1991, in our Centre about 600 patients have been observed. The diagnosis of acute pancreatitis has been posed in 5 patients (0.8%). In 2 of them the course was easy, 2 died and 1 survived despite a number of complications and two surgical operations. Acute pancreatitis is a rare disease in patients on dialysis, but it is more frequent in them than in persons with healthy kidneys. The mortality in those patients is also high. With adequate care and treatment there is a possibility to survive even heavy type of acute pancreatitis.

Acute Disease↗
PubMedDate not supplied

[IgA nephropathy].

A great interest in IgA nephropathy was demonstrated in the last few years. Unfortunately, a complete picture of this chronic disease should not yet been made. The article deals with 7 patients with IgA nephropathy treated in our Institute. The following characteristics were examined during a long period of time (1-17 years): clinical picture, course of the disease, clinical and morphologic correlations. The disease is characterised by micro-and macro-haematuria. In 6 patients a moderate proteinuria and slow progression of the disease were noted. Hypertension, massive proteinuria and azothemia in IgA nephropathy suggested a bad prognosis of the disease. This was confirmed in one patient who developed terminal renal insufficiency within 4 months. The pathological finding by optic microscope revealed a wide spectrum of changes. The role of immunofluorescent microscopy is crucial in the diagnosis of this disease.

Adolescent↗
PubMedDate not supplied

[Arterial hypertension in patients with primary glomerulonephritis].

Arterial hypertension is a state of blood pressure permanently higher than 160/90 mm Hg (21.3/12.6 kPa). The renal cause of hypertension occurs in about 10% of all cases. The aim of this article was to establish the frequency, the level, and the connection of the hypertension in different types of primary glomerulonephritis. In this study 90 patients with primary glomerulonephritis were observed. Hypertension was present in 45 patients (50%) and different frequency were noticed in different types of glomerulonephritis. The smallest frequency was recorded in the group with minimal changes and IgA nephritis. In the group with mesangioproliferative glomerulonephritis 52% of patients had hypertension and in the group with focal segmental sclerosis 78%. The most frequent hypertension was observed in the group with rapidly progressive glomerulonephritis. Renal failure was more frequent in patients with hypertension. Different frequencies of hypertension was established in different types of glomerulonephritis. It was not severe and was well controlled by remedies. In most cases it suggest a severe glomerular lesions and fast progression of the disease.

Adolescent↗