The unilateral thick-walled antrum. A previously unrecognized entity?
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Adult↗
Biomedical subjects
D W Proops
Publications and source records attributed to D W Proops.
Tissue culture of human cholesteatomatous keratinocytes.
The aim of this study was to culture keratinocytes from migratory skin and from cholesteatomatous matrix. At operation, cholesteatomatous matrix, normal drumhead and non-migratory stratifying skin from the extrameatal incision were obtained. Successful cultures of keratinocytes were produced in 4 out of 5 attempts. The cholesteatomatous keratinocytes produced slower growing colonies with an abnormal pattern of keratinization, whereas the drumhead produced rapidly growing colonies with a more regular pattern of keratinization, similar to those obtained from a vertically stratifying epidermis. This method may offer new fields of study in the investigation of cholesteatoma.
Adolescent↗
The definition of branchial cysts, sinuses and fistulae.
In a study of 57 lateral cervical lesions, 46 cysts were found to form a homogeneous group and four sinuses and fistulae formed another homogeneous group. The cysts lay behind the angle of the mandible, and were lined by stratified squamous epithelium resting on lymphoid tissue, with part of the wall resembling a lymph node. The sinuses and fistulae had life-long external openings and were muscular tubes lined by respiratory-type epithelium. The other seven lesions had some other structure. Such uniformity of clinico-pathological features of supposed branchial lesions has not been demonstrated before and no explicit definition of them has ever been published. We suggest that our empirical findings in the two groups of lesions can be used as clinico-pathological definitions of "branchial cysts' and "brachial sinuses and fistula' respectively. Lesions with other features should be given other names.
Adolescent↗
Computed tomography in E.N.T. practice: an evaluation of two years' experience in British sub-regional centre.
The radiological service for otorhinolaryngology in a British subregional centre has been altered by the availability of a general purpose C.T. scanner. Two years' experience with the scanner is reviewed with an attempt to assess how aspects of the improved imaging affected management of patients. The greatest benefit has been in the demonstration of lesions in the perinasal region and C.T. is now the next investigation of choice after plain sinus films, virtually replacing conventional tomography. Computed tomography seems to have little to offer at present for the management of laryngeal lesions, and multidirectional tomography is still the most important means of investigating the temporal bone, despite the difficulty in interpreting the thin low-contrast sections. A simple protocol for the investigation of acoustic neuromas, and a means of certainly excluding the presence of one by demonstrating the structures within the internal auditory meatus, is described.
Child↗
Large vestibular aqueduct syndrome.
A large vestibular aqueduct is one of the commonest radiological abnormalities of the inner ear. A case of acute profound unilateral sensorineural hearing loss and balance disturbance following minor head trauma in the presence of an abnormally enlarged vestibular aqueduct is described. The significance of a diagnosis of large vestibular aqueduct syndrome, in the presence of serviceable hearing, is that it identifies patients who should refrain from activities that increase intracranial pressure to prevent hearing loss.
Acute Disease↗
Verrucous carcinoma of the ear. Case report.
A case report of verrucous carcinoma in the ear of a patient subject to persistent discharge from that ear for more than 30 years is presented. The histology conformed to that in Ackerman's classic description and a literature search revealed that this is only the second case of this disease reported. The patient was treated surgically followed by radiotherapy and was well 18 months later.
Carcinoma, Papillary↗
Histamine levels in middle ear effusions.
The presence of histamine in 131 middle ear effusions was determined by the fluorometric assay technique. This potent mediator of inflammation was found in significant amounts in most of the samples, suggesting that it may play an important role in the pathogenesis of otitis media with effusion. It is postulated that mast cells located in the lamina propria of the tympanic mucoperiosteum are triggered to degranulate and release histamine by anaphylatoxin derived from activation of the complement system.
Adolescent↗
Casts and crusts of the tympanic membrane.
Casts and crusts of the tympanic membrane were removed from patients with previous otitis media. Casts are formed of adherent keratinocytes in a matrix of dried exudate. Detachment from the drumhead leaves the underlying epidermis intact. Casts are defined as those crusts that have detached spontaneously from the surface of the drum. A mechanism based on epithelial proliferation induced by inflammation within the middle ear, with subsequent keratinocyte retention and thickening, is proposed.
Adolescent↗