Biomedical subjects

Demin Han

Publications and source records attributed to Demin Han.

41 records · Page 3Linked to original sources

PubMed2002

[Misdiagnosis of obstructive sleep apnea hypopnea syndrome].

OBJECTIVE: To enhance the understanding of obstructive sleep apnea hypopnea syndrome (OSAHS) and lower its misdiagnosis. METHODS: 6 misdiagnosed cases were analyzed systemically. RESULTS: OSAHS can be misdiagnosed as primary hypertension, arrhythmia, asthma, acalcerosis and some other diseases. The main causes of misdiagnosis were: the main complaints and the main signs could be one or more of a series of symptoms or signs of OSAHS itself or its complications and the lack of systemic knowledge of OSAHS. CONCLUSIONS: The understanding of OSAHS could be enhanced by analyzing misdiagnosis cases.

Adult↗

PubMed2002

[Comparison of neural response telemetry thresholds with behavioral T/C levels].

OBJECTIVE: To provide an objective method to estimate T-levels and C-levels using neural response telemetry (NRT) thresholds for children, from whom we can not get accurate responses because they are very young or have other disabilities, by comparing NRT thresholds and T/C levels. METHODS: Seventy patients implanted with the nucleus CI24M multiple cochlear implant system participated in this study. 329 electrodes were tested. The software used in this study was NRT 2.04. Monopolar stimulation mode was used during NRT threshold measurement. No. 3, 5, 10, 15, 20 electrodes were tested for each patient. The T-levels and C-levels were obtained at the same visit. RESULTS: 92.7% of all the tested electrodes recorded NRT responses. There were variations in the amplitudes and thresholds of NRT responses across subjects and electrodes. NRT thresholds fell within the different points of the MAP dynamic range. The mean of NRT thresholds was shown to fall between the mean of T-levels and C-levels. The NRT thresholds and T/C levels reduced from basal to apical ends of the cochlear. CONCLUSIONS: Considerable variability across subjects was noted. So it is difficult to estimate T-levels and C-levels accurately by testing only NRT thresholds only. NRT technology provides a new objective method for estimating T-levels and C-levels for children who are unable to cooperate with audiologists during mapping after operation. The new NRT technology should be improved in the future.

Adolescent↗

PubMed2002

[Application of endoscopic telescope in the treatment of the juvenile onset recurrent respiratory papillomatosis].

OBJECTIVE: To evaluate the treatment methods of the juvenile onset recurrent respiratory papillomatosis. METHOD: Twelve patients with juvenile onset recurrent respiratory papillomatosis were treated from 1995 to 1999 by using endoscopy. RESULT: Among the 12 cases, 3 cases had no recurrence within one year follow-up and were decannulated,the other 9 cases had recurrence postoperatively, but the recurrence period got longer. CONCLUSION: It is demonstrated that endoscopic surgery is an ideal therapy for the treatment of juvenile onset recurrent respiratory papillomatosis.

Bronchial Neoplasms↗

PubMed2002

[The distribution of metastatic cervical lymph nodes in laryngeal carcinoma].

OBJECTIVE: To detect regularity of lymph nodes metastasis of laryngeal carcinomas and determine the best kind of neck dissection. METHOD: The series consist of three parts:the distribution of laryngeal carcinoma with metastasis lymph nodes, the immunohistochemical evaluation of micrometastases after pathologic diagnostic N0, the distribution of recurrence after operation. All 289 cases in these series including 174 cases of supraglottic carcinoma, 113 cases of glottic carcinomas and 2 cases subglottic carcinomas. RESULT: In the first part, there were 242 necks had been conducted neck dissections and the metastases rates from level I to level VI is 2.8%, 98.3%, 32.6%, 15%, 13%, 21.4% respectively. In the second part, 46 (50 necks) of 71 cases of pathologic N0 necks conducted immunohistochemical study in the lymph nodes. 13 lymph nodes harbor micrometastases, which distributes in 11 cases. All the positive lymph nodes located in level II. In the third part, 45 necks of 37 cases were evaluated the cervical metastasis without neck dissection. The metastases rates from level I to level V is 2.2%, 100%, 48.9%, 26.7%, 13.3% respectively. CONCLUSION: The metastatic lymph nodes of laryngeal carcinomas distribute mainly in level II and level III, followed by level IV and level VI, but rarely in submandibular and posterior triangles. The neck dissection of laryngeal carcinomas should be conducted in the regions from level II to level IV. The dissection of level I and level V should be spared unless there is evidence of metastasis to these regions so as to shorten the operation time and avoid postoperative complications.

Adult↗

PubMed2002

[Prognostic value of the urokinase-type plasminogen activator and its inhibitors in squamous cell carcinoma of human larynx].

OBJECTIVE: The aim of the present study was to evaluate whether the expression of uPA parameters might be of clinical value in squamous cell carcinoma of human larynx as a tumor/biologically defined risk factor. METHOD: In a consecutive series of 127 patients resected for primary squamous cell carcinoma of human larynx, the expression of uPA and plasminogen activator inhibitors (PAI) type-1, type-2 was determined immunohistochemically. The results were classified as positive and negative. Patients were followed-up prospectively for a median of 41 months(rang 6 to 84 months). Overall survival were analyzed according to Kaplan-Meier and log-rank statistics, the prognostic relevance of uPA, PAI-1, PAI-2 and conventional prognostic factors were analyzed by Cox analyses. RESULT: These revealed a high significant inverse correlation of uPA positive expression survival time(P = 0.006); and patients with PAI-2 positive expression had a significantly longer survival time than those with PAI-2 negative expression(P = 0.009); in different clinicopathological parameters subgroups uPA, PAI-2 added significant survival information, whereas PAI-1 positive expression did not associate with prognoses. Patients with uPA-positive/PAI-2-negative expression had the poorest prognoses. Multivariate analysis revealed that four independent prognostic factors for overall survival time were uPA, PAI-2, lymph node metastasis and differentiation of tumor, P = 0.0002, 0.0001, 0.0117, 0.0436 respectively, relative risk and 95% confidence interval were 1.99 (1.39 to 2.85) 0.36 (0.212 to 0.609), 2.36 (1.21 to 4.61) 1.51 (1.01 to 2.25) respectively. CONCLUSION: We conclude that uPA and PAI-2 are new independent and strong biologically prognostic factors, uPA positive expression may be a powerful aid in evaluating metastatic potential and high risk patients in early stage of human larynx carcinoma.

Adult↗