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Biomedical subjects

Demin Han

Publications and source records attributed to Demin Han.

At least 37 records · Page 2Linked to original sources
PubMed2004

[Prevention of complications during paralaryngeal space neoplasms surgery].

OBJECTIVE: To explore the prevention of complications during the the paralaryngeal space (PPS) neoplasms surgery. METHOD: A retrospect study was carried out from 41 patients, suffering from paralaryngeal space neoplasms and recerving surgery from 1990 to 2002. The surgical procedures included oral approach in 6 cases, parotid approach in 6 cases, cervical approach in 25 cases, cervical approach with mandibular swing in 2 cases and lateral skull-base approach 2 in cases. Eight cases got the tracheodectomy during the operations. The tumor in 37 cases were resected throughly, except for 4 cases with partial resection. RESULT: The patients were followed up for 11 months to 6 years. The surgical complications consists of surgical cavity infections in 2 cases, a massive bleeding in 1 case with huge nerve sheath tumor and permanent nerves damage in 7 cases, including Horner's syndrome (2 cases) and nerves damage (5 cases), such as VII, IX, X and XI. Six cases relapsed: 1 case with benign tumor through oral approach and 5 cases with malignant neoplasms. CONCLUSION: Familiarity with PPS anatomy, preoperational evaluation in detail, proper surgery approach and perfect treatment during the operation are vital important to avoid the complications in PPS neoplasms.

Adolescent↗
PubMed2004

[Role of ICAM-1 in eosinophilia and prognosis of nasal polyps].

OBJECTIVE: To investigate the role of adhesion molecule ICAM-1 (Intercellular adhesion molecule-1) in eosinophilia and prognosis of nasal polyps. METHOD: Expression of ICAM-1 were detected and quantified in 35 cases of nasal polyps with fluorescence-immunohistochemistry analysis and its relationships to eosinophilia and prognosis of nasal polyps were evaluated. RESULT: The numbers of eosinophils in nasal polyps and control nasal mucosas were 28.4 +/- 10.7/mm2 and 9.9 +/- 8.6/mm2, and fluorescent densities of ICAM-1 were 115.9 +/- 82.4 and 28.2 +/- 17.1. The expression of ICAM-1 was associated with the heaviness of nasal polyps. CONCLUSION: ICAM-1 may play an important role in the formation and prognosis of nasal polyps.

Adult↗
PubMed2004

[Experimental and clinical study on intraoperative monitoring of facial nerve].

OBJECTIVE: The aim of the study is to determine parameters that be predictive of function of facial nerve after facial nerve decompression surgery. METHOD: Fifteen New Zealand white rabbits (30 facial nerves) and 21 patients with peripheral facial paralysis were monitored intraoperatively during facial nerve decompression surgery. These patients were followed up for at least 6 months. RESULT: Threshold of EMG is a steady parameter of assessing the function of facial nerve. The threshold between different segments of facial nerve has no difference in New Zealand white rabbits. That there exist EMG events were correlated significantly with good postoperative facial nerve function. CONCLUSION: Threshold of EMG can be used as objective and steady parameter that assess the function of facial nerve. Intraoperative monitoring events can be used for assessment of postoperative facial nerve function.

Adolescent↗
PubMed2004

[Vocal function of benign vocal fold lesions and outcomes assessment after CO2 phonomicrosurgery].

OBJECTIVE: To investigate the nature of benign vocal fold lesions and its outcomes assessment after CO2 phonomicrosurgery. METHOD: Vocal function of 292 cases of benign vocal fold lesions (vocal nodules, Reinke's edema, vocal fold cyst, vocal fold polyp and chronic laryngitis) and their outcomes assessment after CO2 phonomicrosurgery were evaluated. Vocal function was examined by acoustic analysis, aerodynamic analysis and videostroboscopic examination. RESULT: Young women with professional occupation were predominant in vocal nodules and the higher age showered in Reinke's edema. Vocal function of vocal nodules and vocal fold polyps had improved distinctly only one month after operation. For Reinke's edema, vocal function can recover three months after operation steadily. Although vocal function of vocal cyst also had improved distinctly only one month after operation, there was depression instead of cyst, the outcome of vocal quality would be affected by that. Vocal function of chronic laryngitis did not change so much after operation. However, ventricular dysphonia did not changed any more. CONCLUSION: Benign vocal fold lesion was located in the cover layer of the vocal fold. According to different lesions, the degree of voice disorder were differently. CO2 phonomicrosurgery can control the range of the operation and protect the cover layers delicately. Vocal function can recover three months after operation steadily. The localized lesions recovered only one month after operation. As the supraglottal hyperfunction remained post-operation, it is regarded as incorrect vocalization and effect on the prognosis.

Female↗
PubMed2003

[Clinical study of uvulopalatopharyngoplasty treatment for middle degree of obstructive sleep apnea syndromes].

OBJECTIVE: In order to investigate the treatment of obstructive sleep apnea syndrome (OSAS) METHOD: The improved uvulopalatopharyngoplasty (UPPP) operations were performed on 64 cases. RESULT: The clinical results showed that 70. Thirty-one percent of the operated patients somewhat improved and 29. Seventy percent unimproved. CONCLUSION: UPPP is one of the effective methods to treat OSAS, especially for OSAS with stricture in pharyngeal cavity. It has less damage, less operative complications and so on.

Adult↗
PubMed2003

[FCM detection and pathology observation of 5 mm cutting-edge of laryngocarcinoma].

OBJECTIVE: To explore the safety of 5 mm cutting-edges with the analysis of DNA contend and cell cycle and the pathology observation. METHOD: Twenty specimens of laryngocarcinoma and its cutting-edges were analyzed by flow cytometry, contrasting to 5 samples of normal larynx tissue, and their light-microscopy and electra-microscopy were discussed. RESULT: The DNA aneuploidy(AN) rate in the laryngocarcinoma, its cutting-edges and the normal tissue is respectively 60% (12/20), 15%(3/20) and 0. The rate of S phrase of the laryngocarcinoma and its cutting-edges is respectively 20.33 +/- 6.0 and 12.35 +/- 3.81, so the DI 1.78 +/- 0.82 and 1.07 +/- 0.04, PI 29.09 +/- 6.8 and 11.75 +/- 3.75, there are significant differences (P < 0.05). The light-microscopy showed 5 mm cutting-edges were infiltrated by carcinoma in the form of submucosa or extention of carcinoma in situ and the results was, to some extension, consistent with the findings of FCM. CONCLUSION: The safety of 5 mm cutting-edge varies depending on whether invading paraglottic space.

Aged↗
PubMed2003

Advantages of using an image-guided system for transnasal endoscopic surgery.

OBJECTIVE: To evaluate the advantages of image-guided system in transnasal endoscopic surgery. METHODS: Transnasal endoscopic surgery was performed with the aid of an image-guided system in 28 patients, supported with histopathologic diagnoses of chronic sinusitis with/without nasal polyps (10 cases), juvenile nasopharyngeal angiofibroma (4 cases), pituitary adenoma (6 cases), ethmoidal ossifying fibroma (3 cases), nasopharyngeal mixed tumor (2 cases), nasal leiomyoma (1 case), fungal sinusitis (1 case) and inverted nasal papilloma (1 case). RESULTS: For all the patients, the time periods from initialization to surgery ranged from 15 to 30 minutes (a mean of 26 minutes). The calibration coefficient ranged from 1.3 to 2.0. Accuracy of localization fell within 1 mm. Compared with traditional endoscopic surgery, operation times were not noticeably different. No complications occurred. CONCLUSIONS: The image-guided system was able to identify borders and critical anatomical structures in real-time, especially of those with distorted anatomical markers. It provided a powerful means for a safer and less invasive endoscopic sinus surgery.

Adolescent↗
PubMed2003

[Expressions of chloride channel ClC-2 and ClC-3 in human nasal polyps].

OBJECTIVE: To investigate the role of chloride channel ClC-2 and ClC-3 in human nasal polyps. METHOD: Two chloride channels ClC-2 and ClC-3 were studied in 27 cases of nasal polyps with immunochemistric staining. RESULT: Nasal polyps revealed strong positive staining of ClC-2 and ClC-3, the ClC-2 and ClC-3 proteins localized mainly in epithelial cells, sub-epithelial mucous glands without significant distinction. The number of positive cells of ClC-2 and ClC-3 are 17.6 +/- 6.33 and 23.49 +/- 6.14. CONCLUSION: The chloride channels ClC-2 and ClC-3 may play a role in the formation of nasal polyps.

Adult↗
PubMed2003

[Experimental study on olfactory evoked potential in rabbits].

OBJECTIVE: To observe olfactory evoked potential(OEPs) produced by electrical stimulation of the olfactory mucosa and to find out an objective way to appraise olfactory function. METHOD: A bipolar stimulus electrode was placed on the olfactory mucosa of adult health rabbits via anterior naris. Olfactory evoked potential was recorded at headtop after being given a 0.5-4.0 mA current to the mucosa. And we also investigated the effect of stimulus parameters and stimulus location to the wave form of OEPs. RESULT: Triphasic negative-positive-negative evoked potentials were recorded from the surface of the frontal head close to olfactory bulb. Latent period of three waves respectively was N(1)20.6 ms, P(1)33.5 ms, N(2)58.3 ms. CONCLUSION: In general, the OEPs were composed of triphasic negative-positive-negative complexes. The waveforms were stable and could be repeated well. Each parameter was useful for estimating the olfactory function.

Animals↗
PubMed2002

[Study on voice quality after different layers injured in vocal fold with CO2 laser microsurgery].

OBJECTIVE: To investigate the nature of pathological voice after injured in different layers of vocal fold with CO2 laser microsurgery. METHOD: 50 cases of precancerous lesion (keratosis and leukoplakia) were treated with laser mucosa ablation. Glottal carcinoma (Tis-T2) were treated with laser microsurgery in mucosal stripping(30 cases) or with laser cordectomy(60 cases). Vocal function was examined by acoustic analysis (F0, Jitter, Shimmer, NNE, HNR), aerodynamic analysis (MPT, S/Z) and videostroboscopic examination. RESULT: For lesion mucosa ablation, hoarseness improved quickly after operation and acoustic analysis became normal. There were 18.2% decreased mucosa wave, 16.7% mild-moderate supraglottal hyperfunction. For mucosa stripping (cover layers excised), 63.3% decreased and 10.0% absented with mucosa wave, 46.7% mild-moderate supraglottal hyperfunction, glottal closure was incomplete. Acoustic analysis showed that Jitter, Shimmer, F0 different from normal(P < 0.05), HNR significantly different from normal(P < 0.01). For cordectomy: Acoustic analysis showed significantly worse than normal(P < 0.01), 61.7% mild-moderate supraglottal hyperfunction. The ipsilateral mucosa wave was absent, but 30.0% showed mucosa wave of vocal process and 13.3% with ventricular fold wave. There was little difference with or without vocalis muscle excision in acoustic analysis. To compared with mucosa stripping, the NNE, HNR, Jitter, Shimmer of cordectomy group was worse and amplitude was higher in cordectomy(P < 0.01). CONCLUSION: Although the acoustic characteristic and vibration mode of mucosa ablation and mucosa stripping was distinct to each other, within the cover layer injured, vocal function will be good. Once the body layer is injured, vocal quality will decrease significantly.

Adult↗
PubMed2002

[Study on voice characteristics of people with different sexes and ages].

OBJECTIVE: To study the voice characteristics and differences of normal people with different sexes and ages, and to analyze the related factors, adopt suitable acoustic parameter values. METHOD: To collect and analyze acoustic parameter values of 1200 normal people who were divided by sex (male and female) and age (group 1: before puberty; group 2: after puberty to 30; group 3: 31 to 45; group 4: 46 to 60; 5: 61 and older), laryngeal manifestations of different sex and age under stroboscopy were analyzed. RESULT: Acoustic parameters of men and women have different characteristics. (1) F0, jitter, NNE of women voice are significantly higher than men. (2) Voice amplitude, MPT and formant frequencies of men are significantly higher than those of women. (3) Male and female voice characteristics and anatomic and physiological mechanisms of different age--groups are different. CONCLUSION: Acoustic parameters of normal people with different sexes and ages have different characteristics, which are related to anatomic and physiological mechanisms and other factors.

Adolescent↗
PubMed2002

[Mechanism of esophageal speech after total laryngectomy].

OBJECTIVE: To evaluate the characteristics of esophageal speech after total laryngectomy. METHODS: Esophageal speech evaluation of 40 cases of esophageal phonation included acoustic parameters, intraesophageal pressures during phonation, speech intelligibility, fluency, communication, respiratory sound and cognate distinctions between voiced and voiceless sounds. RESULTS: In 8 poor speakers, the neoglottis was spasmodic and difficult to vibrate during phonation. In 32 good speakers, the neoglottis was relaxed and easy to vibrate during phonation. The training age, speech intelligibility, fluency, communication, respiratory sound, cognate distinctions between voiced and voiceless sounds and intraesophageal pressures during phonation were significantly different between good and poor esophageal speakers. Vocal characteristics of good speakers differed significantly from those in the normal (P < 0.05 or P < 0.01). The upper intraesphageal pressure during esophageal phonation was higher than that of the normal, especially for poor esophageal phonation. The middle to lower intraesphageal pressures was highest during poor esophageal phonation. CONCLUSIONS: Esophageal phonation was completely alaryngeal, and its activators also differ completely, so phonation could not maintain much longer. Patients with poor esophageal phonation could not drive the air through the neoglottis freely.

Adult↗
PubMed2002

[Allergic fungal sinusitis: report of three cases].

OBJECTIVE: To discuss and analyze the diagnosis and management of allergic fungal sinusitis. METHOD: Three middle-aged patients with allergic fungal sinusitis (AFS) were observed. The histological diagnosis was made on the mucous material and allergy evaluation based on the strong history of inhalant mold allergies, a positive result of skin test, total immunoglobulin E level and radioallergosorbent test to fungal antigens. The management included wide local endoscopic sinus debridement, adequate sinus aeration, postoperative use of systemic and intranasal corticosteroid. Systemic antifungal therapy was not used. RESULTS: All 3 patients were immunocompetent and none demonstrated histologic evidence of tissue invasion. Two patients remained disease-free during follow-up ranging for a mean of 16 months, 1 patient recurred 17 months after operation and symptom-free for 2 months after re-cleaning of the sinus cavity. CONCLUSION: Diagnosis of AFS required a high index of suspicion. A confirmatory diagnosis was made from the inspissated mucus, clinical and CT findings along with careful communication with mycologists and immunologists about the possibilities of fungal growth and allergy. Costly and lengthy courses of antibiotics, aggressive surgery should be avoided. Surgical debridement and systemic corticosteroids followed by intranasal corticosteroids might provide long-term control of AFS.

Adult↗
PubMed2002

[Measurement of nasal airway resistance and olfactory function before and after endoscopic sinus surgery].

OBJECTIVE: To quantitatively analyse the changes of nasal airway resistance (NAR) and olfactory function in patients before and after endoscopic sinus surgery(ESS). METHODS: NAR and olfactory functions in 127 patients suffering from chronic sinusitis and/or nasal polyps were measured with anterior rhinomanometry and T&T olfactometer standard odors. RESULTS: 1. The degree of NAR increased and olfactory dysfunction were accompanied with varied clinic classifications. 2. After the ESS, NAR decreased and olfactory functions improved obviously, the effective rates were 93.4% (85/91) and 71.9% (64/89) respectively. 3. Allergy was one of the major factors that affected the outcome of nasal function after ESS. CONCLUSIONS: 1. The improvements of NAR and olfactory function in patients with chronic sinusitis and polyps were significant after ESS. 2. As the determining method of nasal function, the measurement of NAR and olfactory function ought to be used widely in clinical practice.

Adolescent↗
PubMed2002

[Evaluate the curative effect of CO2 laser in treatment of glottic carcinoma].

OBJECTIVE: To evaluate the curative effect of CO2 laser in treatment of glottic carcinoma. METHODS: Retrospective analysis of 217 cases of early glottic laryngeal carcinoma treated with laser surgery were carried out. Among these cases, Tis were 22 cases, T1a 108 cases, T1b 38 cases, T2 46 cases, T3 3 cases. 1 case being applied vocal cord excision due to failure of tumor exposure. The follow-up period was 3 to 9 years. RESULTS: Relapse were detected in 21 out of 217 cases of glottic laryngeal carcinoma after CO2 laser surgery under self-retaining laryngoscope. The recurrent rate was 9.7% (21/217). Recurrent ratio of T1a, T1b, T2, T3 were 5.6% (6/108), 21% (8/38), 13.0% (6/46), 1/3 respectively, with significant differences among groups (chi 2 = 6.102, P < 0.01). The recurrent rate was 21.6% of tumors offended the anterior commissure, versus 5.1%(8/157) with no involvement of anterior commissure (chi 2 = 13.64, P < 0.01). 217 cases received laser surgery as the only treatment, 201 cases were still alive. 4 failed to be followed-up(taken into dead number), 12 cases were dead. 3 year survival rate was 97.2%(211/217), 5 year survival rate was 89.4%(118/132). CONCLUSION: It was reliable to use laser surgery in treatment of early glottic laryngeal cancer. The advantages of it included lower complication rate and vocal function was well retained.

Adult↗
PubMed2002

[Polygraphic characteristics of upper airway resistance syndrome].

OBJECTIVE: (1) To analyze upper airway resistance syndrome (UARS) patients' polysomnographic characteristics, to lower the misdianosis of UARS. (2) To improve the understanding of UARS. METHODS: (1) Select 12 UARS patients diagnosed by PSG and continuous esophageal pressure measurement, the sleep structure, arousal index, apnea hyponea index (AHI) were analyzed, the body mass index (BMI), epworth sleepiness scale (ESS) were calculated. (2) Select 16 simple snoring cases as the control group, obstructive sleep apnea syndrome (OSAS) and UARS were ruled out by PSG and continuous esophageal pressure measurement for this group of cases. (3) Compare the 2 groups' first night PSG indexes (4) Compare the 2 nights PSG indexes of the UARS group, to see the continuous esophageal pressure measurement effects on their sleep. RESULTS: (1) There are no statistical difference of the 2 group's BMI and AHI. (2) Compared with the control group, UARS patients got higher arousal index and ESS score, more sleep stage 1 and stage 2, less sleep stage 3 and stage 4. (3) The 2 nights PSG indexes of UARS patients are not statistically different. CONCLUSIONS: (1) Compared with simple snoring cases, the UARS patients have some special characteristics, i.e., higher arousal index, less deep sleep, and higher ESS score, combined with the clinical manifestations, it is possible to screen UARS patients. (2) No evident effects of continuous esophageal pressure measurement on UARS patients sleep.

Adult↗
PubMed2002

[Assess respiratory drive by esophageal pressure measurement].

OBJECTIVE: To evaluate the difference between the classificatory results of esophagus pressure monitor and thorax and abdomen belt. METHODS: From Nov. 2000 to Jan. 2001, 34 patients received polysomnographic examination in Beijing Tongren Hospital. The aero digestive pressure was monitored simultaneously at 4 different points, i.e., the distal part of esophagus, hypopharynx, oropharynx and nasopharynx. Respiratory events were classified based on measurement of thorax and abdomen movements and esophageal pressure, and two classification results were compared. RESULTS: Four patients were excluded from comparing classification results because of apnea hypopnea index < 5, or deformity in face and low sleep efficiency. Other 30 patients, 26 men and 4 women, at age of 45.4 +/- 9.5 (30-66), were enrolled. Classificatory difference was found in 9.7% (1,183 out of 12,238) of the respiratory events between two methods. The largest part of apneas reclassified by esophageal pressure measurement were mixed apneas reclassified as obstructive apnea (600). The difference of respiratory drive restore time measured by two methods was found between mixed reclassified obstructive apneas and mixed apneas confirmed by two methods, P = 0.028. No difference between mixed reclassified obstructive apneas and obstructive apneas confirmed by two methods. Difference of apnea classifications was due to the changes of respiratory drive restore time caused by different sensitivity of respiratory drive measurement. The number of difference was related to sensitivity of thorax and abdominal channel (P = 0.000, r2 = 0.653). CONCLUSION: Apneas are easy to be misclassified due to the low sensitivity of thoracic and abdominal channel, and this problem can be solved by using esophageal pressure measurement. All kinds of apneas have anatomic and neuro-muscular factor in common.

Adult↗